Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Hao-Wen Sim"'
Autor:
Laveniya Satgunaseelan, Maggie Lee, Sebastian Iannuzzi, Susannah Hallal, Kristine Deang, Kristian Stanceski, Heng Wei, Sofia Mason, Brindha Shivalingam, Hao-Wen Sim, Michael E. Buckland, Kimberley L. Alexander
Publikováno v:
Cancers, Vol 16, Iss 10, p 1906 (2024)
(1) Background: MGMT (O-6-methylguanine-DNA methyltransferase) promoter methylation remains an important predictive biomarker in high-grade gliomas (HGGs). The influence of necrosis on the fidelity of MGMT promoter (MGMTp) hypermethylation testing is
Externí odkaz:
https://doaj.org/article/695dbd433fa54826bac9ea8aad4ad39e
Autor:
Georgia K. B. Halkett, Lauren J. Breen, Melissa Berg, Rebecca Sampson, Hao-Wen Sim, Hui K. Gan, Benjamin Y. Kong, Anna K. Nowak, Bryan W. Day, Rosemary Harrup, Melissa James, Frank Saran, Brett Mcfarlane, Chris Tse, Eng-Siew Koh
Publikováno v:
Current Oncology, Vol 29, Iss 12, Pp 9928-9955 (2022)
The aim of this project was to determine research priorities, barriers, and enablers for adult primary brain tumour research in Australia and New Zealand. Consumers, health professionals, and researchers were invited to participate in a two-phase mod
Externí odkaz:
https://doaj.org/article/6cd87a96459d43ed8dda66d8c3a38599
Autor:
Omali Pitiyarachchi, Yeh Chen Lee, Hao-Wen Sim, Sivatharsny Srirangan, Cristina Mapagu, Judy Kirk, Paul R. Harnett, Rosemary L. Balleine, David D.L. Bowtell, Goli Samimi, Alison H. Brand, Deborah J. Marsh, Philip Beale, Lyndal Anderson, Natalie Bouantoun, Pamela Provan, Susan J. Ramus, Anna DeFazio, Michael Friedlander
Publikováno v:
Translational Oncology, Vol 31, Iss , Pp 101638- (2023)
Background: Somatic pathogenic variants (PVs) in homologous recombination DNA repair (HR)-related genes found in high-grade serous ovarian carcinomas (HGSC) are not well-characterised in older patients (≥70 years). This may reflect low testing rate
Externí odkaz:
https://doaj.org/article/05e8b7eb7bab4b7a9ce7d16d06ef35d0
Autor:
Sarah M. Trinder, Campbell McKay, Phoebe Power, Monique Topp, Bosco Chan, Santosh Valvi, Geoffrey McCowage, Dinisha Govender, Maria Kirby, David S. Ziegler, Neevika Manoharan, Tim Hassall, Stewart Kellie, John Heath, Frank Alvaro, Paul Wood, Stephen Laughton, Karen Tsui, Andrew Dodgshun, David D. Eisenstat, Raelene Endersby, Stephen J. Luen, Eng-Siew Koh, Hao-Wen Sim, Benjamin Kong, Nicholas G. Gottardo, James R. Whittle, Dong-Anh Khuong-Quang, Jordan R. Hansford
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
The mitogen-activated protein kinase (MAPK) pathway signaling pathway is one of the most commonly mutated pathways in human cancers. In particular, BRAF alterations result in constitutive activation of the rapidly accelerating fibrosarcoma–extracel
Externí odkaz:
https://doaj.org/article/b70dc0b5bc9c4f5f8e61a5acca858e20
Autor:
Zarnie Lwin, Eng-Siew Koh, Elizabeth H Barnes, Rosemary Harrup, Hui K Gan, Anna K Nowak, Craig Gedye, Sonia Yip, Benjamin Y Kong, Hao-Wen Sim, Jonathon Parkinson, Rosalind Jeffree, Elizabeth J Hovey, Merryn Hall, Emily Tu, Mark B Pinkham, Candace Carter, Anthony Dowling, John S Simes
Publikováno v:
BMJ Open, Vol 12, Iss 9 (2022)
Introduction Glioblastoma (GBM) is the most common malignant primary central nervous system cancer in adults. The objective of the Multi-Arm GlioblastoMa Australasia (MAGMA) trial is to test hypotheses in real world setting to improve survival of peo
Externí odkaz:
https://doaj.org/article/e3e6c47aec9f4f8cacc7e973ad7a136f
Autor:
Mohammed A. Alghamdi, Carla P. Amaro, Richard Lee‐Ying, Hao‐Wen Sim, Haider Samwi, Kelvin K. Chan, Jennifer J. Knox, Yoo‐Joung Ko, Mina Swiha, Eugene Batuyong, Adriana Romagnino, Winson Y. Cheung, Vincent C. Tam, the Hepatocellular Carcinoma ‐ Cancer Health Outcomes Research Database (HCC ‐ CHORD) Consortium
Publikováno v:
Cancer Medicine, Vol 9, Iss 14, Pp 4918-4928 (2020)
Abstract Background Sorafenib has been shown to improve survival in patients with advanced hepatocellular carcinoma (HCC), however, full dose can be difficult to tolerate. The aim of this study was to determine whether sorafenib starting dose and mea
Externí odkaz:
https://doaj.org/article/f30b00a8c00b40719fb7ffe444f5c912
Autor:
Andrea S. Fung, Vincent C. Tam, Daniel E. Meyers, Hao‐Wen Sim, Jennifer J. Knox, Valeriya Zaborska, Janine Davies, Yoo‐Joung Ko, Eugene Batuyong, Haider Samawi, Winson Y. Cheung, Richard Lee‐Ying
Publikováno v:
Cancer Medicine, Vol 9, Iss 13, Pp 4640-4647 (2020)
Abstract Background The CELESTIAL, RESORCE, and REACH‐2 trials showed survival benefit of cabozantinib, regorafenib, and ramucirumab, respectively, in hepatocellular carcinoma (HCC) patients treated with sorafenib who had good performance status (E
Externí odkaz:
https://doaj.org/article/f4695cfcaa624e019d0cbdbba425df4f
Autor:
Di M. Jiang, Chihiro Suzuki, Osvaldo Espin‐Garcia, Charles H. Lim, Lucy X. Ma, Peiran Sun, Hao‐Wen Sim, Akina Natori, Bryan A. Chan, Stephanie Moignard, Eric X. Chen, Geoffrey Liu, Carol J. Swallow, Gail E. Darling, Rebecca Wong, Raymond W. Jang, Elena Elimova
Publikováno v:
Cancer Medicine, Vol 9, Iss 9, Pp 3023-3032 (2020)
Abstract Background The goal of surveillance testing is to enable curative salvage therapy through early disease detection, however supporting evidence in gastroesophageal adenocarcinoma is limited. We evaluated frequency of successful salvage therap
Externí odkaz:
https://doaj.org/article/c307b0469a764a6eb8cd13f50c8acbc5
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Aggressive pituitary tumors (APTs) are associated with significant morbidity and mortality, and effective treatment options are limited. Immune checkpoint inhibitors (ICIs) have revolutionized clinical cancer care; however, there is little experience
Externí odkaz:
https://doaj.org/article/311244e69a514362a94c61ea3349f3fd
Publikováno v:
Cancers, Vol 14, Iss 4, p 1003 (2022)
Gliomas are the most common malignant primary brain tumor in adults. Despite advances in multimodality therapy, incorporating surgery, radiotherapy, systemic therapy, tumor treating fields and supportive care, patient outcomes remain poor, especially
Externí odkaz:
https://doaj.org/article/00cfb69855a140eb8390d91b8d349cc0