Výsledky vyhledávání - "Hao-Kuen Lin"

Akademický článek

Functional buffering via cell-specific gene expression promotes tissue homeostasis and cancer robustness

Autor: Hao-Kuen Lin, Jen-Hao Cheng, Chia-Chou Wu, Feng-Shu Hsieh, Carolyn Dunlap, Sheng-hong Chen

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)

Abstract Functional buffering that ensures biological robustness is critical for maintaining tissue homeostasis, organismal survival, and evolution of novelty. However, the mechanism underlying functional buffering, particularly in multicellular orga

Externí odkaz: https://doaj.org/article/e368c6cb31354f1d94c386ddff87c733

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Abstract P2-23-14: Molecular characterization of HER2-low invasive breast carcinoma by quantitative RT-PCR using Oncotype DX®

Autor: Mariya Rozenblit, Hao-Kuen Lin, Nhu Thuy Can, Cynthia A. Flannery, Jess Hoag, Alekhya Akkunuri, Helen Bailey, Frederick Baehner, Lajos Pusztai

Publikováno v: Cancer Research. 83:P2-23

Background: The DESTINY-Breast04 clinical trial demonstrated the superiority of trastuzumab deruxtecan (T-DXd) versus physician’s choice chemotherapy in HER2-low [immunohistochemistry (IHC) staining score 1+ or 2+ with no gene amplification by in-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c7b23b6209b7035fb8eb0396f114834
https://doi.org/10.1158/1538-7445.sabcs22-p2-23-14

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PD-L1 protein expression in relation to recurrence score values in early-stage ER + breast cancer

Autor: Mariya Rozenblit, Kim Blenman, Malini Harigopal, Emily Reisenbichler, Kamaljeet Singh, Tao Qing, Eiman Ibrahim, Shakti Ramkissoon, Sem Asmelash, Hao-Kuen Lin, Mustimbo Roberts, Jeffrey Ross, Richard S. P. Huang, Lajos Pusztai

Publikováno v: Breast cancer research and treatment. 196(1)

We assessed associations between PD-L1 protein expression, RS, tumor grade, and stromal tumor-infiltrating lymphocyte (TIL) count in early-stage ER + cancers.FFPE tissue blocks of 213 patients with RS in 2012-2017 were identified. PD-L1 immunohistoch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71fd4452fb55930b542dfc8ab9aacef1
https://pubmed.ncbi.nlm.nih.gov/36028784

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Functional buffering via cell-specific gene expression promotes tissue homeostasis and cancer robustness

Autor: Feng-Shu Hsieh, Jen-Hao Cheng, Chia-Chou Wu, Carolyn A Dunlap, Hao-Kuen Lin, Sheng-hong Chen

Functional buffering that ensures biological robustness is critical for maintaining tissue homeostasis, organismal survival, and evolution of novelty. However, the mechanism underlying functional buffering, particularly in multicellular organisms, re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a93d57318d5220c9b09667606b452b0
https://doi.org/10.1101/2021.07.26.453775

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