Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Hao Ying Xu"'
Autor:
Hao Ying Xu, Wei Liu, Feng Gu, Bin Zou, Wai Ling Chan, Paul W. Smith, Kah Fei Wan, Ratna Karuna, Agatha Susila, Peck Gee Seah, Andy Yip, Pei Yong Shi, Trixie Wagner, Thierry T. Diagana, Qing Yin Wang, Alex Chao, Mei Ding, Hongping Dong, Seh Yong Leong, Francesca Blasco, Katherine Chan, Shahul Nilar, Ina Dix
Publikováno v:
ACS Medicinal Chemistry Letters. 6:344-348
Spiropyrazolopyridone 1 was identified, as a novel dengue virus (DENV) inhibitor, from a DENV serotype 2 (DENV-2) high-throughput phenotypic screen. As a general trend within this chemical class, chiral resolution of the racemate revealed that R enan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9867f21db7401bc0dd808defa261115
https://doi.org/10.1021/ml500521r
https://doi.org/10.1021/ml500521r
Autor:
Hao Ying Xu, Michal Tichý, Radek Pohl, Fumiaki Yokokawa, Michal Hocek, Pei Yong Shi, Yen Liang Chen
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:6123-6133
A series of new pyrimido[4,5-b]indole ribonucleosides bearing phenyl or hetaryl group at position 4 has been prepared by selective Pd-catalyzed cross-coupling reactions of the corresponding protected 4,6-dichloropyrimido[4,5-b]indole ribonucleoside w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbceea15e6c6f6e7172329b54c447d01
https://doi.org/10.1016/j.bmc.2012.08.021
https://doi.org/10.1016/j.bmc.2012.08.021
Autor:
Laura D. Kramer, Qing Yin Wang, Hao Ying Xu, Zhiming Yuan, Min Qing, Xuping Xie, Pei Yong Shi
Publikováno v:
Journal of Virology. 85:11183-11195
We report a novel inhibitor that selectively suppresses dengue virus (DENV) by targeting viral NS4B protein. The inhibitor was identified by screening a 1.8-million-compound library using a luciferase replicon of DENV serotype 2 (DENV-2). The compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f25caab313e759c3342fc6d39e270ad
https://doi.org/10.1128/jvi.05468-11
https://doi.org/10.1128/jvi.05468-11
Publikováno v:
Antiviral Research. 91:11-19
To facilitate dengue virus (DENV) drug discovery, we developed a stable luciferase reporter DENV-2. A renilla luciferase gene was engineered into the capsid-coding region of an infectious cDNA clone of DENV-2. Transfection of BHK-21 cells with the cD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd6291aaab587334791332d8b4b1fc7
https://doi.org/10.1016/j.antiviral.2011.05.001
https://doi.org/10.1016/j.antiviral.2011.05.001
Publikováno v:
Antimicrobial Agents and Chemotherapy. 54:3686-3695
Brequinar is an inhibitor of dihydroorotate dehydrogenase, an enzyme that is required for de novo pyrimidine biosynthesis. Here we report that brequinar has activity against a broad spectrum of viruses. The compound not only inhibits flaviviruses (de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32cad4c3287e0968a87f7764b3f810a1
https://doi.org/10.1128/aac.00561-10
https://doi.org/10.1128/aac.00561-10
Autor:
Suresh B. Lakshminarayana, Andy Yip, Anne Goh, Margaret Weaver, Wouter Schul, Boping Liu, Yen Liang Chen, Hao Ying Xu, Min Qing, Véronique Dartois, Thomas H. Keller, Pei Yong Shi, Zheng Yin, Jeyaraj Duraiswamy, Ravinder Reddi Kondreddi
Publikováno v:
Antimicrobial Agents and Chemotherapy. 54:3255-3261
Dengue virus (DENV) is the most prevalent mosquito-borne viral pathogen that infects humans. Neither a vaccine nor an antiviral therapy is currently available for DENV. Here, we report an adenosine nucleoside prodrug that potently inhibits DENV repli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3290aa194c7fc884048d3f526432c92f
https://doi.org/10.1128/aac.00397-10
https://doi.org/10.1128/aac.00397-10
Autor:
Wai Ling Chan, Bo Zhang, Thomas H. Keller, Wouter Schul, Min Qing, Pei Yong Shi, Andy Yip, Kristen A. Bernard, Gang Zou, Hao Ying Xu, Suresh B. Lakshminarayana, Gang Wang, Anne Goh, Wei Liu, Min Dong, Boping Liu, Hui Pen Tan, Handan He, Qing Yin Wang, Margaret Weaver, Feng Gu, Yen Liang Chen, Zheng Yin, Pornwaratt Niyomrattanakit, Chuan Young Ng, Arkadius Pichota, Christine E. Garrett, Véronique Dartois, Joanne Y.H. Lim, Ravinder Reddy Kondreddi, Jeyaraj Duraiswamy, Kai Lin, Chin Chin Lim, Karen Beltz
Publikováno v:
Proceedings of the National Academy of Sciences. 106:20435-20439
Dengue virus (DENV), a mosquito-borne flavivirus, is a major public health threat. The virus poses risk to 2.5 billion people worldwide and causes 50 to 100 million human infections each year. Neither a vaccine nor an antiviral therapy is currently a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a316c5d40ed9639ddcd32990e5f5a43e
https://doi.org/10.1073/pnas.0907010106
https://doi.org/10.1073/pnas.0907010106
Autor:
Feng Gu, Mee Kian Poh, Wai Yee Phong, Subhash G. Vasudevan, Edgar Jacoby, Olivier Heudi, Hao Ying Xu, Deana Jaber, Sejal J. Patel, Ngai Ling Ma, Ranga Rao, Wouter Schul, Eric Vangrevelinghe, Thomas H. Keller, Qing-Yin Wang
Publikováno v:
Antimicrobial Agents and Chemotherapy. 53:1823-1831
The incidence of dengue fever epidemics has increased dramatically over the last few decades. However, no vaccine or antiviral therapies are available. Therefore, the need for safe and effective antiviral drugs has become imperative. The entry of den
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860f8efa995a625b6264862dabe5459c
https://doi.org/10.1128/aac.01148-08
https://doi.org/10.1128/aac.01148-08
Autor:
Qing Yin Wang, Yen Liang Chen, Hao Ying Xu, K.L. Yeo, Hongping Dong, Pei Yong Shi, Fumiaki Yokokawa
Dengue virus (DENV) is the most prevalent mosquito-borne viral pathogen in humans. Currently, there is no clinically approved vaccine or antiviral for DENV. Combination therapy is a common practice in antiviral treatment and a potential approach to s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b129686c93da4981fbfe43c7a79a692
https://europepmc.org/articles/PMC4356831/
https://europepmc.org/articles/PMC4356831/
Publikováno v:
Chinese Journal of Integrative Medicine. 10:162-169
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d833b9f68d00f3768db9544a5c97560c
https://doi.org/10.1007/bf02836399
https://doi.org/10.1007/bf02836399