'Perfect' designer chromosome V and behavior of a ring derivative

Autor: Ning Zhi Liu, Wen Zheng Zhang, Qiu Hui Lin, Ting Liu, Jing Sheng Cheng, Mei Qing Fu, Kun Yang, Ming Zhu Ding, Ran Tao, J. Andrew Martin, Yue Shen, Xia Li, Jef D. Boeke, Guo Zhen Jiang, Zhi Chao Yu, Si Chen, Wan Su, Jin Gui Liu, Jian Jun Qiao, Yan Wang, Shi Yang Liu, Wen Qian Zhang, Su Wang, Hang Xu, Shi Lei Han, Wei Liu, Ken Chen, Yi Wu, Yue Liu, Ze-Xiong Xie, Juan Zhao, Yi Lin Liu, Roy Walker, Li Xiang Song, Ye Xuan Deng, Xuya Wang, Xia Wang, Rui Guo, Leslie A. Mitchell, Joel S. Bader, Ting Ting Zhang, Ming Hua Shen, Guang Rong Zhao, Xiao Tong Wei, Xiao Ran Xu, Bing-Zhi Li, Jun Qi Zhu, Ying-Jin Yuan, Hao Xing Du, Bo Xuan Zeng, Yi Ran Wang, Bin Jia, Zheng Kuang, Shi Lan Yang, Ting Li, Lan Meng Qu, Jia Qing Zhu, Kai Ren Tian, Ping Sheng Ma, Tian Qing Song, Xue Nan Li, Guang Xin Ye, Cheng Hu, Huanming Yang, Jia Fei Lv, Wei Zhang, Yisha Luo, Qi Feng, Zhu Jin, Zhen Ning Liu, Wen Qi Ding, Fang Zhai, Xin Qi, Jin Hua Zhang, Xiao Le Wu, Yizhi Cai, Meng Zhao, Xue Jiao Guo, Xue Bai, Jun Jun Dai, Meng Long Hu, Fei Fei Li, Si Yu Xin, Xiao Na Yang, En Xu Wang, Giovanni Stracquadanio, Hui Min Liu, Lin Ting Wang, Chun-Ting Zhang, Zheng Bao Xia, Da Shuai Li, Yun Wang, Nan Jia

Publikováno v: Xie, Z-X, Li, B-Z, Mitchell, L A, Wu, Y, Qi, X, Jin, Z, Jia, B, Wang, X, Zeng, B-X, Liu, H-M, Wu, X-L, Feng, Q, Zhang, W-Q, Liu, W, Ding, M-Z, Li, X, Zhao, G-R, Qiao, J-J, Cheng, J-S, Zhao, M, Kuang, Z, Wang, X, Martin, J A, Stracquadanio, G, Yang, K, Bai, X, Zhao, J, Hu, M-L, Lin, Q-H, Zhang, W-Q, Shen, M-H, Chen, S, Su, W, Wang, E-X, Guo, R, Zhai, F, Guo, X-J, Du, H-X, Zhu, J-Q, Song, T-Q, Dai, J-J, Li, F-F, Jiang, G-Z, Han, S-L, Liu, S-Y, Yu, Z-C, Yang, X-N, Chen, K, Hu, C, Li, D-S, Jia, N, Liu, Y, Wang, L-T, Wang, S, Wei, X-T, Fu, M-Q, Qu, L-M, Xin, S-Y, Liu, T, Tian, K-R, Li, X-N, Zhang, J-H, Song, L-X, Liu, J-G, Lv, J-F, Xu, H, Tao, R, Wang, Y, Zhang, T-T, Deng, Y-X, Wang, Y-R, Li, T, Ye, G-X, Xu, X-R, Xia, Z-B, Zhang, W, Yang, S-L, Liu, Y-L, Ding, W-Q, Liu, Z-N, Zhu, J-Q, Liu, N-Z, Walker, R, Luo, Y, Wang, Y, Shen, Y, Yang, H, Cai, Y, Ma, P-S, Zhang, C-T, Bader, J S, Boeke, J D & Yuan, Y-J 2017, ' "Perfect" designer chromosome V and behavior of a ring derivative ', Science, vol. 355, no. 6329 . https://doi.org/10.1126/science.aaf4704

INTRODUCTION The Saccharomyces cerevisiae 2.0 project (Sc2.0) aims to modify the yeast genome with a series of densely spaced designer changes. Both a synthetic yeast chromosome arm (synIXR) and the entirely synthetic chromosome (synIII) function wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38923b67576ca15f20973c8d990e9b6
https://doi.org/10.1126/science.aaf4704

Engineering Yarrowia lipolytica for Campesterol Overproduction

Autor: Duo Liu, Hao-Xing Du, Ying Wang, Xiao Zhou, Ying-Jin Yuan, Yu Zhang, Wen-Hai Xiao

Publikováno v: PLoS ONE, Vol 11, Iss 1, p e0146773 (2016)
PLoS ONE

Campesterol is an important precursor for many sterol drugs, e.g. progesterone and hydrocortisone. In order to produce campesterol in Yarrowia lipolytica, C-22 desaturase encoding gene ERG5 was disrupted and the heterologous 7-dehydrocholesterol redu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c973e865620aed483e8ccb599e004c0c
http://europepmc.org/articles/PMC4709189?pdf=render