Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Hao‐Jie Zhu"'
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 12, Pp 2796-2811 (2022)
Abstract Several human host proteins play important roles in the lifecycle of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Many drugs targeting these host proteins have been investigated as potential therapeutics for coronavirus
Externí odkaz:
https://doaj.org/article/d5a78bcf529f4948966d8233e7214afd
Autor:
Alessandra M. Campos-Staffico, Michael P. Dorsch, Geoffrey D. Barnes, Hao-Jie Zhu, Nita A. Limdi, Jasmine A. Luzum
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Background: Atrial fibrillation (AF) is the leading cause of ischemic stroke and treatment has focused on reducing this risk through anticoagulation. Direct Oral Anticoagulants (DOACs) are the first-line guideline-recommended therapy since they are a
Externí odkaz:
https://doaj.org/article/af9cafd7d4eb474ba36521f3cc5f0100
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 4, Pp 1380-1389 (2021)
Abstract Trandolapril, an angiotensin‐converting enzyme inhibitor prodrug, needs to be activated by carboxylesterase 1 (CES1) in the liver to exert its intended therapeutic effect. A previous in vitro study demonstrated that the CES1 genetic varian
Externí odkaz:
https://doaj.org/article/3c56a76ba6a64afe9f523de9df7b2c63
Autor:
Xue‐Qiong Wu, Kang‐Ni Lin, Min‐Min Chen, Pei‐Fang Jiang, Yu‐Xin Zhang, Yong‐Quan Chen, Qiu‐Ru Chen, Min Xiao, Hao‐Jie Zhu, Hajji Ally Issa, Shao‐Zhen Chen, Xiao‐Feng Luo, Jin‐Hua Ren, Qian Li, Yan‐Ling Zeng, Jing‐Jing Xu, Yi‐Feng Lin, Rong Zheng, Zhi‐Hong Zheng, Zhi‐Zhe Chen, Jian‐Da Hu, Ting Yang
Publikováno v:
Kaohsiung Journal of Medical Sciences, Vol 36, Iss 10, Pp 825-833 (2020)
Abstract Hematological malignancies are increasingly treated with allogeneic hematopoietic stem cell transplantation (allo‐HSCT). Unfortunately, iron overload is a frequent adverse effect of allo‐HSCT and is associated with poor prognosis. In the
Externí odkaz:
https://doaj.org/article/95cca827550e4396bfb09bdb6578d90f
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-16 (2020)
Abstract Background Previous expression quantitative trait loci (eQTL) studies have identified thousands of genetic variants to be associated with gene expression at the mRNA level in the human liver. However, protein expression often correlates poor
Externí odkaz:
https://doaj.org/article/c38235ee29174bdd98de1f0639dba69a
Publikováno v:
Frontiers in Materials, Vol 8 (2021)
Multi-bolt shear connectors (MBSCs), arranging bolts as a group in several rows, can be applied in prefabricated steel–concrete composite beams or bridges (SCCBs) to reduce the construction time and meet the requirements of sustainable development.
Externí odkaz:
https://doaj.org/article/4ff686c66510460e9de654b08a1ae601
Publikováno v:
Drug Metabolism Handbook. :143-176
Publikováno v:
Clinical and Translational Science. 15:2796-2811
Several human host proteins play important roles in the lifecycle of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Many drugs targeting these host proteins have been investigated as potential therapeutics for coronavirus disease 2019
Publikováno v:
Journal of Pharmaceutical Sciences. 111:2606-2613
The pharmacokinetics (PK) of methylphenidate (MPH) differ significantly among individuals. Carboxylesterase 1 (CES1) is the primary enzyme metabolizing MPH, and its function is affected by genetic variants, drug-drug interaction (DDI), and sex. The o
Publikováno v:
Pharmaceutics, Vol 13, Iss 10, p 1656 (2021)
ProTide technology is a powerful tool for the design of nucleoside/nucleotide analog prodrugs. ProTide prodrug design improves cell permeability and enhances intracellular activation. The hydrolysis of the ester bond of a ProTide is a determinant of
Externí odkaz:
https://doaj.org/article/a6f2d2001e3444d2890cb0e5c51f3991