Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Hanyong, Chen"'
Autor:
Fanxiang Yin, Ran Zhao, Dhilli Rao Gorja, Xiaorong Fu, Ning Lu, Hai Huang, Beibei Xu, Hanyong Chen, Jung-Hyun Shim, Kangdong Liu, Zhi Li, Kyle Vaughn Laster, Zigang Dong, Mee-Hyun Lee
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 11, Pp 4122-4137 (2022)
Colorectal cancer (CRC) is the second most common cause of cancer-related death in the world. The pro-viral integration site for Moloney murine leukemia virus 1 (PIM1) is a proto-oncogene and belongs to the serine/threonine kinase family, which are i
Externí odkaz:
https://doaj.org/article/5e196dc1029c489b8bc9f8c40f5aa4d5
Autor:
Xuechao Jia, Chuntian Huang, Yamei Hu, Qiong Wu, Fangfang Liu, Wenna Nie, Hanyong Chen, Xiang Li, Zigang Dong, Kangdong Liu
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-15 (2021)
Abstract Background Esophageal squamous cell carcinoma (ESCC) is an aggressive and lethal cancer with a low 5 year survival rate. Identification of new therapeutic targets and its inhibitors remain essential for ESCC prevention and treatment. Methods
Externí odkaz:
https://doaj.org/article/fe80249ddb764005af50a0b3f0581f1a
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Jian Li and Xinli Ma et al. present a 2.53 Å crystal structure of a complex consisting of the human p53-related protein kinase (PRPK), TP53RK-binding protein, and adenylyl-imidodiphosphate. They find that one disease mutation, PRPK K238Nfs*2, is imp
Externí odkaz:
https://doaj.org/article/2380b20c8fa54b79b126890583543b59
Autor:
Fangfang Liu, Qiong Wu, Wei Han, Kyle Laster, Yamei Hu, Fayang Ma, Hanyong Chen, Xueli Tian, Yan Qiao, Hui Liu, Dong Joon Kim, Zigang Dong, Kangdong Liu
Publikováno v:
Clinical and Translational Medicine, Vol 11, Iss 10, Pp n/a-n/a (2021)
Abstract Rationale A high risk of post‐operative recurrence contributes to the poor prognosis and low survival rate of oesophageal squamous cell carcinoma (ESCC) patients. Increasing experimental evidence suggests that integrin adhesion receptors,
Externí odkaz:
https://doaj.org/article/46e4d8dde5d54c939d1a3ec337e277bf
Autor:
Yanan Jiang, Jing Zhang, Jimin Zhao, Zhenzhen Li, Hanyong Chen, Yan Qiao, Xinhuan Chen, Kangdong Liu, Ziming Dong
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-14 (2019)
Abstract Background Esophageal squamous cell carcinoma (ESCC) is a fatal disease with poor prognosis. The predominant reason for ESCC-related death is distal metastasis. A comprehensive understanding of the molecular mechanism underlying metastasis i
Externí odkaz:
https://doaj.org/article/79696e179feb46d2891bd71f1d71dbaf
Autor:
Simin Zhao, Ke Yao, Dan Li, Kangdong Liu, Guoguo Jin, Mingyang Yan, Qiong Wu, Hanyong Chen, Seung Ho Shin, Ruihua Bai, Gangcheng Wang, Ann M. Bode, Ziming Dong, Zhiping Guo, Zigang Dong
Publikováno v:
EBioMedicine, Vol 44, Iss , Pp 361-374 (2019)
Background: Our preclinical data showed that the leukotriene A4 hydrolase (LTA4H) pathway plays a role in colorectal cancer (CRC). High expression of LTA4H and leukotriene B4 receptor type 1 (BLT1) were also associated with CRC survival probability.
Externí odkaz:
https://doaj.org/article/2ac8c422d98b4506a56f7b2077c71234
Autor:
Ji Hye Kim, Jae-Eun Lee, Taewon Kim, Myung Hun Yeom, Jun Seong Park, Eric di Luccio, Hanyong Chen, Zigang Dong, Ki Won Lee, Nam Joo Kang
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
7,3′,4′-Trihydroxyisoflavone (7,3′,4′-THIF) is a metabolite of daidzein which is a representative isoflavone found in soybean. Recent studies suggested that 7,3′,4′-THIF exerts a hypopigmentary effect in B16F10 cells, however, its underly
Externí odkaz:
https://doaj.org/article/fc6fba09f39c4f2399fbf709265a4bbd
Autor:
Man Zhang, Jie Tian, Rui Wang, Mengqiu Song, Ran Zhao, Hanyong Chen, Kangdong Liu, Jung-Hyun Shim, Feng Zhu, Zigang Dong, Mee-Hyun Lee
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Lung cancer is a leading cause cancer-related death with diversity. A promising approach to meet the need for improved cancer treatment is drug repurposing. Dasatinib, a second generation of tyrosine kinase inhibitors (TKIs), is a potent treatment ag
Externí odkaz:
https://doaj.org/article/fd648382fe1e41d2be2db8c9cd70b05c
Autor:
Seung Ho Shin, Do Young Lim, Kanamata Reddy, Margarita Malakhova, Fangfang Liu, Ting Wang, Mengqiu Song, Hanyong Chen, Ki Beom Bae, Joohyun Ryu, Kangdong Liu, Mee-Hyun Lee, Ann M. Bode, Zigang Dong
Publikováno v:
EBioMedicine, Vol 25, Iss C, Pp 22-31 (2017)
Colorectal cancer is associated with aberrant activation of the Wnt pathway. β-Catenin plays essential roles in the Wnt pathway by interacting with T-cell factor 4 (TCF4) to transcribe oncogenes. We synthesized a small molecule, referred to as HI-B1
Externí odkaz:
https://doaj.org/article/7ef1fa25b8f14e63908d778f34dab03d
Autor:
Zigang Dong, Ziming Dong, Ann M. Bode, Wei-Ya Ma, Hong-Gyum Kim, Ki Beom Bae, Haitao Li, Mee-Hyun Lee, Myoung Ok Kim, Dong Hoon Yu, Yi Zhang, Ge Yang, Alyssa Langfald, Kangdong Liu, Hanyong Chen, Ke Yao
RSK2 and MSK1 play an important role in Ras-mediated foci formation. A focus formation assay was performed by introducing combinations of vectors as indicated. Foci were stained with 0.5% crystal violet and counted under a microscope using the Image-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15677a86d1ba0ee2391c82dd00df3a1a
https://doi.org/10.1158/1940-6207.22524797.v1
https://doi.org/10.1158/1940-6207.22524797.v1