Spatially resolved phosphoproteomics reveals fibroblast growth factor receptor recycling-driven regulation of autophagy and survival

Autor: Joanne Watson, Harriet R. Ferguson, Rosie M. Brady, Jennifer Ferguson, Paul Fullwood, Hanyi Mo, Katherine H. Bexley, David Knight, Gareth Howell, Jean-Marc Schwartz, Michael P. Smith, Chiara Francavilla

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)

Recruitment of Receptor Tyrosine Kinase signalling partners during endocytosis, specifically during recycling to the plasma membrane, is crucial to signal propagation and regulation. Here, the authors reveal FGFR signalling partners proximal to recyc

Externí odkaz: https://doaj.org/article/7ca1d246354d484086dace8d1d9fc7b7

Data integration and mechanistic modelling for breast cancer biology: Current state and future directions

Autor: Hanyi Mo, Rainer Breitling, Chiara Francavilla, Jean-Marc Schwartz

Publikováno v: Mo, H, Breitling, R, Francavilla, C & Schwartz, J 2022, ' Data integration and mechanistic modelling for breast cancer biology: current state and future directions ', Current Opinion in Endocrine and Metabolic Research, vol. 24, 100350 . https://doi.org/10.1016/j.coemr.2022.100350, https://doi.org/10.1016/j.coemr.2022.100350

Breast cancer is one of the most common cancers threatening women worldwide. A limited number of available treatment options, frequent recurrence, and drug resistance exacerbate the prognosis of breast cancer patients. Thus, there is an urgent need f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d904b2714f815081e04fc3c0794a2e
https://doi.org/10.1016/j.coemr.2022.100350