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Smad3 gene C‐terminal phosphorylation site mutation aggravates CCl 4 ‐induced inflammation in mice

Autor: Guanghua Wen, Chong Zhang, Dong Li, Chao Wu, Yan Yang, Meng Fang, Hanyan Ding, Jingjing Yang, Yongfang Gong

Publikováno v: Journal of Cellular and Molecular Medicine. 24:7044-7054

The expression of C-terminal phosphorylated Smad3 (pSmad3C) is down-regulated with the progression of liver disease. Thus, we hypothesized that pSmad3C expression may be negatively related to liver disease. To develop novel therapeutic strategies, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::334929807123f6b94c206abc846d7bd6
https://doi.org/10.1111/jcmm.15385

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Salvianolic acid B protects against acute and chronic liver injury by inhibiting Smad2C/L phosphorylation

Autor: Yan Yang, Yuan-Yuan Xu, Chao Wu, Wanpeng Lu, Xiang-Ming Tao, Hanyan Ding, Yue Kan, Dong Li, Chong Zhang, Guanghua Wen

Publikováno v: Experimental and Therapeutic Medicine

Salvianolic acid B (Sal B) has strong antioxidant and anti-fibrosis effects, which are related to the transforming growth factor β/Smad signaling pathway. However, how Sal B affects this antioxidant pathway and the phosphorylation (p-) of Smad2 at b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c32dd949d9952df847aa9d7586a13f
https://doi.org/10.3892/etm.2021.9772

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Smad3 gene C-terminal phosphorylation site mutation aggravates CCl

Autor: Hanyan, Ding, Meng, Fang, Yongfang, Gong, Dong, Li, Chong, Zhang, Guanghua, Wen, Chao, Wu, Jingjing, Yang, Yan, Yang

Publikováno v: Journal of Cellular and Molecular Medicine

The expression of C‐terminal phosphorylated Smad3 (pSmad3C) is down‐regulated with the progression of liver disease. Thus, we hypothesized that pSmad3C expression may be negatively related to liver disease. To develop novel therapeutic strategies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a32b26615a57ed5116169e1398e6270d
https://pubmed.ncbi.nlm.nih.gov/32406200

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Salvianolic acid B exerts anti-liver fibrosis effects via inhibition of MAPK-mediated phospho-Smad2/3 at linker regions in vivo and in vitro

Autor: Yan Yang, Dong Li, Guanghua Wen, Ming Chen, Chong Zhang, Weiyang Chen, Chao Wu, Hanyan Ding, Wanpeng Lu

Publikováno v: Life sciences. 239

Aim To investigate anti-liver fibrosis effects of Salvianolic acid B (Sal B) from Salvia miltiorrhiza Bunge involved mitogen-activated protein kinase (MAPK)-mediated transforming growth factor-beta (TGF-β) signaling. Main methods Diethylnitrosamine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::022711274b9d0debe3a3a7093c1bf6dd
https://pubmed.ncbi.nlm.nih.gov/31678285

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Smad3 C-terminal phosphorylation site mutation attenuates the hepatoprotective effect of salvianolic acid B against hepatocarcinogenesis

Autor: Yan Yang, Dong Li, Hanyan Ding, Chong Zhang, Zhirui Fang, Guanhua Wen, Shu Hou, Juan Yang, Lili Li, Chao Wu, Yongfang Gong

Publikováno v: Food and Chemical Toxicology. 147:111912

Smad3 phosphorylation is implicated in hepatic fibro-carcinogenesis. Moreover, Smad3 phospho-isoform pSmad3L and pSmad3C are reversible and antagonistic, and the balance could shift from carcinogenesis to tumor-suppression. pSmad3C has recently assig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d15fb6c2aa379a901a7418fb60bdacfd
https://doi.org/10.1016/j.fct.2020.111912

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