Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Hany S, Ibrahim"'
Autor:
Marten A. Fischer, Al-Hassan M. Mustafa, Kristin Hausmann, Ramy Ashry, Anita G. Kansy, Magdalena C. Liebl, Christina Brachetti, Andrea Piée-Staffa, Matthes Zessin, Hany S. Ibrahim, Thomas G. Hofmann, Mike Schutkowski, Wolfgang Sippl, Oliver H. Krämer
Publikováno v:
Journal of Advanced Research, Vol 60, Iss , Pp 201-214 (2024)
Introduction: Posttranslational modification of proteins by reversible acetylation regulates key biological processes. Histone deacetylases (HDACs) catalyze protein deacetylation and are frequently dysregulated in tumors. This has spurred the develop
Externí odkaz:
https://doaj.org/article/0bdd50c9fd09429e928b1f2b75be1138
Publikováno v:
BMC Chemistry, Vol 17, Iss 1, Pp 1-18 (2023)
Abstract New thienopyrimidine derivatives were designed and synthesized as GSK-3β inhibitors based on the structure of active binding site of GSK-3β enzyme. In this study, compounds 6b and 6a were found to be moderate GSK-3β inhibitors with IC50s
Externí odkaz:
https://doaj.org/article/cbc2cb83300d45038d4d9da4cf299556
Autor:
Heba Abdelrasheed Allam, Mohamed E. Albakry, Walaa R. Mahmoud, Alessandro Bonardi, Shaimaa A. Moussa, Samy Mohamady, Hatem A. Abdel-Aziz, Claudiu T. Supuran, Hany S. Ibrahim
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Design and synthesis of three novel series of aryl enaminones (3a–f and 5a–c) and pyrazole (4a-c) linked compounds with sulphonamides, sulfaguanidine, or carboxylic acid functionalities were reported as carbonic anhydrase inhibitors (CAIs) using
Externí odkaz:
https://doaj.org/article/2fc7d8be1b5b42cb8ed9a28b78cc2fa3
Autor:
Hany S. Ibrahim, Wolfgang Sippl
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 23, p 16985 (2023)
Epigenetic processes modulate gene transcription and genomic stability, ensuring proper cell development and differentiation [...]
Externí odkaz:
https://doaj.org/article/de86a40b93b0437280250c89ffe07c72
Autor:
Samy Mohamady, Mahmoud Galal, Wagdy M. Eldehna, David C. Gutierrez, Hany S. Ibrahim, Mohey M. Elmazar, Hamed I. Ali
Publikováno v:
ACS Omega, Vol 5, Iss 30, Pp 18872-18886 (2020)
Externí odkaz:
https://doaj.org/article/23d5741367504f79b321ba0c10018bc7
Autor:
Mohamed A. Abdelrahman, Wagdy M. Eldehna, Alessio Nocentini, Hany S. Ibrahim, Hadia Almahli, Hatem A. Abdel-Aziz, Sahar M. Abou-Seri, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 298-305 (2020)
Pursuing on our efforts toward searching for efficient hCA IX and hCA XII inhibitors, herein we report the design and synthesis of new sets of benzofuran-based sulphonamides (4a,b, 5a,b, 9a–c, and 10a–d), featuring the zinc anchoring benzenesulfo
Externí odkaz:
https://doaj.org/article/ff8ba644da4c499a8fe3a841533c748c
Autor:
Hany S. Ibrahim, Wolfgang Sippl
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Externí odkaz:
https://doaj.org/article/f1f421678ee04c2184f703cdeb75b316
Autor:
Emre F. Bülbül, Jelena Melesina, Hany S. Ibrahim, Mohamed Abdelsalam, Anita Vecchio, Dina Robaa, Matthes Zessin, Mike Schutkowski, Wolfgang Sippl
Publikováno v:
Molecules, Vol 27, Iss 8, p 2526 (2022)
Class I histone deacetylases, HDAC1, HDAC2, and HDAC3, represent potential targets for cancer treatment. However, the development of isoform-selective drugs for these enzymes remains challenging due to their high sequence and structural similarity. I
Externí odkaz:
https://doaj.org/article/05b8cc97c3804454871db793df609555
Autor:
Wagdy M. Eldehna, Dina H. EL-Naggar, Ahmed R. Hamed, Hany S. Ibrahim, Hazem A. Ghabbour, Hatem A. Abdel-Aziz
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 309-318 (2018)
Triple-negative breast cancer (TNBC) is a highly aggressive malignancy with limited treatment options due to its heterogeneity and the lack of well-defined molecular targets. In our endeavour towards the development of novel anti-TNBC agents, herein
Externí odkaz:
https://doaj.org/article/5a47e7e6b78641e1865f454417c7aa1a
Autor:
Wagdy M. Eldehna, Mahmoud F. Abo-Ashour, Hany S. Ibrahim, Ghada H. Al-Ansary, Hazem A. Ghabbour, Mahmoud M. Elaasser, Hanaa Y. A. Ahmed, Nesreen A. Safwat
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 686-700 (2018)
On account of their significance as apoptosis inducing agents, merging indole and 3-hydrazinoindolin-2-one scaffolds is a logic tactic for designing pro-apoptotic agents. Consequently, 27 hybrids (6a–r, 9a–f and 11a–c) were synthesised and eval
Externí odkaz:
https://doaj.org/article/d5ad79c0e553437ca23de71e8a6713c4