Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Hany Ghabrial"'
Publikováno v:
Canadian Journal of Gastroenterology, Vol 5, Iss 2, Pp 77-81 (1991)
A variety of tests has been used to assess liver function and predict hepatic functional reserve in patients with liver disease. These tests comprise clinical assessment, simple biochemical measurements and so-called ‘quantitative’ tests of liver
Externí odkaz:
https://doaj.org/article/f5d8c44d25564277af9750a37b5577bd
Autor:
Mark E. Cooper, Zemin Cao, Tanya M. Osicka, Josephine M. Forbes, Hany Ghabrial, Merlin C. Thomas, Phillip Kantharidis, Wendy C. Burns, Leileata M. Russo, Vicki Thallas, Chris Tikellis, George Jerums
Publikováno v:
Kidney International. 63(6):2152-2161
Reduced tubular cation transport in diabetes: Prevented by ACE inhibition. Background The renal clearance of organic cations is important for the homeostasis of a number of exogenous and endogenous compounds. The organic cation transporters (OCTs) si
Autor:
Denis J. Morgan, Henri Tochon-Danguy, John I. Sachinidis, Andrew M. Scott, Peter W Angus, Paul R. Froomes, Michael S. Ching, Hany Ghabrial
Publikováno v:
Nuclear Medicine and Biology. 30:93-100
Measurement of hepatic sinusoidal permeability of oxygen and other substrates may help elucidate the mechanisms responsible for impaired liver function in cirrhosis. However studies of sinusoidal oxygen permeability in normal liver and various diseas
Autor:
Richard B Sewell, Michael S Nobes, Hany Ghabrial, Richard A. Smallwood, Katrina M Simms, Denis J. Morgan
Publikováno v:
Journal of Gastroenterology and Hepatology. 17:598-605
Background: In the erythrocytic phase of malaria, Kupffer cells show marked hypertrophy and hyperplasia and are filled with malarial pigment. However, phagocytic function in this state has not been well characterized. The aim of the present study was
Publikováno v:
Pharmacology & Toxicology. 88:3-15
After the transition from in utero to newborn life, the neonate becomes solely reliant upon its own drug clearance processes to metabolise xenobiotics. Whilst most studies of neonatal hepatic drug elimination have focussed upon in vitro expression an
Publikováno v:
Xenobiotica. 31:757-767
1. The inhibition of recombinant CYP1A1 and CYP1A2 activity by quinidine and quinine was evluated using ethoxyresorutin O-deethylation, phenacetin O-deethylation and propranolol desisopropylation as probe catalytic pathways. 2. With substrate concent
Publikováno v:
Pharmacogenetics. 10:591-603
The tricyclic antidepressant, doxepin, is formulated as an irrational mixture of E (trans) and Z (cis) stereoisomers (85%: 15%). We examined the stereoselective metabolism of doxepin in vitro, with the use of human liver microsomes, recombinant CYP2D
Autor:
Denis J. Morgan, Michael S. Ching, Richard A. Smallwood, Arthur Shulkes, Paul J Gow, Saard Treepongkaruna, Hany Ghabrial
Publikováno v:
Journal of Pharmaceutical Sciences. 89:586-593
Using the isolated perfused neonatal sheep liver model, we examined the disposition of propranolol ( n = 8, age 0.25–10 days) and compared our findings with our previous study from the perfused near‐term fetal sheep liver (Ring JA, et al. 1995 .
Autor:
Michael S. Ching, Arthur Shulkes, Paul J Gow, Denis J. Morgan, Richard A. Smallwood, Hany Ghabrial, Saard Treepongkaruna
Publikováno v:
Journal of Pharmaceutical Sciences. 89:36-44
We examined the metabolism of para‐nitrophenol (PNP) in the isolated perfused neonatal sheep liver ( n = 8, 0.25–11 days) and compared the findings with our previous data from the perfused near‐term fetal sheep liver (Ring, J. A., et al. Drug M
Publikováno v:
Pharmacology & Therapeutics. 84:429-445
The majority of studies of fetal hepatic elimination have concentrated on the expression and activity of the metabolizing enzymes, but the unique physiologic milieu of the fetal liver should also be considered. The basic structure of the liver is for