Pharmacological implications of ipriflavone against environmental metal–induced neurodegeneration and dementia in rats

Autor: Hend M. Hussien, Hany E.A. Ahmed, Samar R. Saleh, Doaa A. Ghareeb, Hani S. Hafez

Publikováno v: Environmental Science and Pollution Research. 28:65349-65362

Long-term exposure to environmental neurotoxic metals is implicated in the induction of dementia and cognitive decline. The present study aims to illustrate the therapeutic role of ipriflavone as a synthetic isoflavone against environmental metal–i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bf27d5588a2c5e53a6e64665b289976
https://doi.org/10.1007/s11356-021-15193-7

S-substituted 2-mercaptoquinazolin-4(3H)-one and 4-ethylbenzensulfonamides act as potent and selective human carbonic anhydrase IX and XII inhibitors

Autor: Alaa A.-M. Abdel-Aziz, Silvia Bua, Adel S. El-Azab, Nawaf A. Alsaif, Manal A. El-Gendy, Alessio Nocentini, Hany E.A. Ahmed, Claudiu T. Supuran, Mohammed M. Alanazi

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 733-743 (2020)
Journal of Enzyme Inhibition and Medicinal Chemistry

We evaluated the hCA (CA, EC 4.2.1.1) inhibitory activity of novel 4-(2-(2-substituted-thio-4-oxoquinazolin-3(4H)-yl)ethyl)benzenesulfonamides (compounds 2–20) towards the isoforms I, II, IX, and XII. hCA Isoforms were effectively inhibited by most

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a044e2e3e9e9321fd7197f7f05bc317d
https://doi.org/10.1080/14756366.2020.1742117

Developing lipophilic aromatic halogenated fused systems with specific ring orientations, leading to potent anticancer analogs and targeting the c-Src Kinase enzyme

Autor: Hany E.A. Ahmed, Tarek H. Afifi, Mohammed A. A. El-Nassag, Ateyatallah Aljuhani, Ahmed M. Fouda, Ahmed M. El-Agrody, Ahmed H. Hassan, Saleh Ihmaid, Essam Shawky A. E. H. Khattab, Hany M. Mohamed, Ahmed Halawa, Rawda M. Okasha, Shimaa M. Abd El-Gilil

Publikováno v: Journal of Molecular Structure. 1186:212-223

This work presents the combined microwave assisted synthesis, spectroscopic analyses, cytotoxic effects, and molecular docking studies of the chromene fused ring systems with various substituents of the terminal halogenated phenyl ring derivatives of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c89348c60655ba564f51309b93d9b2a
https://doi.org/10.1016/j.molstruc.2019.03.012

Synthesis, antimicrobial evaluation, DNA gyrase inhibition, and in silico pharmacokinetic studies of novel quinoline derivatives

Autor: Hany E.A. Ahmed, Khaled El-Adl, Kamal M. El-Gamal, Mohamed H. El-Shershaby, Ashraf H. Bayoumi, Hamada S. Abulkhair

Publikováno v: Archiv der PharmazieREFERENCES. 354(2)

Herein, we report the synthesis and in vitro antimicrobial evaluation of novel quinoline derivatives as DNA gyrase inhibitors. The preliminary antimicrobial activity was assessed against a panel of pathogenic microbes including Gram-positive bacteria

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4abae4936a89161c552d7707b39a90df
https://pubmed.ncbi.nlm.nih.gov/33078877

Novel triazolophthalazine-hydrazone hybrids as potential PCAF inhibitors: Design, synthesis, in vitro anticancer evaluation, apoptosis, and molecular docking studies

Autor: Adel Ghiaty, Ashraf H. Bayoumi, Hamada S. Abulkhair, Abdallah Turky, Hany E.A. Ahmed

Publikováno v: Bioorganic chemistry. 100

Three novel series of triazolophthalazine derivatives bearing hydrazone moiety were designed, synthesized, and evaluated for their anticancer activity against four human cancer cell lines by MTT assay. Six derivatives demonstrated comparable activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f2e0bb98e33f01092d2c4c53bca226
https://pubmed.ncbi.nlm.nih.gov/32454390