Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Hanxin, Lin"'
Autor:
Pratibha Bhai, Benjamin Chin-Yee, Victor Pope, Ian Cheong, Maxim Matyashin, Michael A. Levy, Aidin Foroutan, Alan Stuart, Cyrus C. Hsia, Hanxin Lin, Bekim Sadikovic, Ian Chin-Yee
Publikováno v:
Current Oncology, Vol 29, Iss 10, Pp 7209-7217 (2022)
Background: Since the identification of JAK2 V617F and exon 12 mutations as driver mutations in polycythemia vera (PV) in 2005, molecular testing of these mutations for patients with erythrocytosis has become a routine clinical practice. However, the
Externí odkaz:
https://doaj.org/article/3f897fc6e5724f84ae1912b24b087ec4
Autor:
Pratibha Bhai, Jacob Turowec, Stephanie Santos, Jennifer Kerkhof, LeeAnne Pickard, Aidin Foroutan, Daniel Breadner, Matthew Cecchini, Michael A. Levy, Alan Stuart, Stephen Welch, Christopher Howlett, Hanxin Lin, Bekim Sadikovic
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundPersonalized targeted therapies have transformed management of several solid tumors. Timely and accurate detection of clinically relevant genetic variants in tumor is central to the implementation of molecular targeted therapies. To facilit
Externí odkaz:
https://doaj.org/article/aa56f829f46649b0a40108279d31d700
Autor:
Nika Maani, Karen Panabaker, Jeanna M. McCuaig, Kathleen Buckley, Kara Semotiuk, Kirsten M. Farncombe, Peter Ainsworth, Seema Panchal, Bekim Sadikovic, Susan Randall Armel, Hanxin Lin, Raymond H. Kim
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-7 (2021)
Abstract Next-generation sequencing (NGS) technologies have facilitated multi-gene panel (MGP) testing to detect germline DNA variants in hereditary cancer patients. This sensitive technique can uncover unexpected, non-germline incidental findings in
Externí odkaz:
https://doaj.org/article/51d40d0aa8aa4187b039858a26fe2992
Autor:
Hanxin Lin, Cheryl Xiaoning Long
Publikováno v:
China Economic Quarterly International, Vol 1, Iss 2, Pp 160-175 (2021)
The management by administrative authorities of law violations represents one of the instruments for enforcing laws in China, the other way is lawsuit. The law allows administrative discretion to achieve efficiency but may lead to unfair law enforcem
Externí odkaz:
https://doaj.org/article/42b537dd07ef4fdbbb197afa593908fb
Autor:
Mei Zheng, Xuesen Zhao, Shuangli Zheng, Danying Chen, Pengcheng Du, Xinglin Li, Dong Jiang, Ju-Tao Guo, Hui Zeng, Hanxin Lin
Publikováno v:
Emerging Microbes and Infections, Vol 9, Iss 1, Pp 1567-1579 (2020)
ABSTRACTDiverse SARS-like coronaviruses (SL-CoVs) have been identified from bats and other animal species. Like SARS-CoV, some bat SL-CoVs, such as WIV1, also use angiotensin converting enzyme 2 (ACE2) from human and bat as entry receptor. However, w
Externí odkaz:
https://doaj.org/article/b53a2e0ff49b4cd3a52029ee3de7e357
Autor:
Parisa Sooshtari, Biao Feng, Saumik Biswas, Michael Levy, Hanxin Lin, Zhaoliang Su, Subrata Chakrabarti
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0270287 (2022)
BackgroundHyperglycemia-induced transcriptional alterations lead to aberrant synthesis of a large number of pathogenetic molecules leading to functional and structural damage to multiple end organs including the kidneys. Diabetic nephropathy (DN) rem
Externí odkaz:
https://doaj.org/article/906d3dad6556477da2634372afc53db5
Autor:
Pratibha Bhai, Michael A. Levy, Kathleen Rooney, Deanna Alexis Carere, Jack Reilly, Jennifer Kerkhof, Michael Volodarsky, Alan Stuart, Mike Kadour, Karen Panabaker, Laila C. Schenkel, Hanxin Lin, Peter Ainsworth, Bekim Sadikovic
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
BackgroundHereditary cancer predisposition syndromes account for approximately 10% of cancer cases. Next generation sequencing (NGS) based multi-gene targeted panels is now a frontline approach to identify pathogenic mutations in cancer predispositio
Externí odkaz:
https://doaj.org/article/22fc06b1488549319e08328937c5ba16
Autor:
Danying Chen, Zhifei Hou, Dong Jiang, Mei Zheng, Guoli Li, Yue Zhang, Rui Li, Hanxin Lin, Jinhong Chang, Hui Zeng, Ju-Tao Guo, Xuesen Zhao
Publikováno v:
Emerging Microbes and Infections, Vol 8, Iss 1, Pp 1511-1523 (2019)
ABSTRACTInterferons (IFNs) control viral infections by inducing expression of IFN-stimulated genes (ISGs) that restrict distinct steps of viral replication. We report herein that gamma-interferon-inducible lysosomal thiol reductase (GILT), a lysosome
Externí odkaz:
https://doaj.org/article/f22fd231b9944beba50e35e378fd1e9b
Autor:
Erfan Aref-Eshghi, Eric G. Bend, Rebecca L. Hood, Laila C. Schenkel, Deanna Alexis Carere, Rana Chakrabarti, Sandesh C. S. Nagamani, Sau Wai Cheung, Philippe M. Campeau, Chitra Prasad, Victoria Mok Siu, Lauren Brady, Mark A. Tarnopolsky, David J. Callen, A. Micheil Innes, Susan M. White, Wendy S. Meschino, Andrew Y. Shuen, Guillaume Paré, Dennis E. Bulman, Peter J. Ainsworth, Hanxin Lin, David I. Rodenhiser, Raoul C. Hennekam, Kym M. Boycott, Charles E. Schwartz, Bekim Sadikovic
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Mutations in genes encoding subunits of the BAF complex can cause Coffin–Siris and Nicolaides–Baraitser syndromes. Here the authors identify overlapping DNA methylation signatures in individuals with subtypes of these two syndromes that suggest a
Externí odkaz:
https://doaj.org/article/c8cbaa6df3ca4918a79caee26f70b7d7
Autor:
Laila C. Schenkel, Erfan Aref-Eshghi, Cindy Skinner, Peter Ainsworth, Hanxin Lin, Guillaume Paré, David I. Rodenhiser, Charles Schwartz, Bekim Sadikovic
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-11 (2018)
Abstract Background Claes-Jensen syndrome is an X-linked inherited intellectual disability caused by mutations in the KDM5C gene. Kdm5c is a histone lysine demethylase involved in histone modifications and chromatin remodeling. Males with hemizygous
Externí odkaz:
https://doaj.org/article/f391ff28057f4241b38e4796222c339f