Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Hanwei Yin"'
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 169, Iss , Pp 115822- (2023)
Pulmonary fibrosis is highly lethal with limited treatments. Butaselen (BS) is an inhibitor of thioredoxin reductase (TrxR)/thioredoxin (Trx) with anti-tumor activity. However, its impact on pulmonary fibrosis and the involved mechanisms remain uncle
Externí odkaz:
https://doaj.org/article/91b88e05646b42f6a3a30b48c1c16596
Autor:
Cheng Yang, Mingzhen Xue, Yifei He, Hanwei Yin, Chen Yang, Dafang Zhong, Huihui Zeng, Yuandong Zheng, Xingxing Diao
Publikováno v:
Molecules, Vol 28, Iss 24, p 8102 (2023)
BS1801 is a selenium-containing drug candidate with potential for treating liver and lung fibrosis. To fully elucidate the biotransformation of BS1801 in animals and provide sufficient preclinical drug metabolism data for human mass balance study, th
Externí odkaz:
https://doaj.org/article/3221faee8fe74356b98f1b1d552cc9b4
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Hepatic cancer is often amenable to surgery, including percutaneous ablation, trans-arterial chemoembolization. However, in metastatic cases, surgery is often not an effective option. Chemotherapy as a conventional clinical method for treatm
Externí odkaz:
https://doaj.org/article/ea2342db5ee242668d9b3e5263a5e4c3
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Liver fibrosis is an important stage in the progression of liver injury into cirrhosis or even liver cancer. Hepatic stellate cells (HSCs) are induced by transforming growth factor-β1 (TGF-β1) to produce α-smooth muscle actin (α-SMA) and collagen
Externí odkaz:
https://doaj.org/article/6efe36b03007483cbb4015368a658121
Publikováno v:
The Journal of Immunology. 210:681-695
Hepatocellular carcinoma (HCC) has the third highest cancer-related mortality rate globally. The immunosuppressive microenvironment of HCC limits effective treatment options. HCC cells and associated microenvironmental factors suppress NK and T cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b409890ad803c8a78f9d4c449d19027c
https://doi.org/10.4049/jimmunol.2200389
https://doi.org/10.4049/jimmunol.2200389
Publikováno v:
Redox Biology, Vol 32, Iss , Pp - (2020)
Externí odkaz:
https://doaj.org/article/9cc7e66a25564a928c0866ea09a507c9
Publikováno v:
Redox Biology, Vol 14, Iss , Pp 237-249 (2018)
Hepatocellular carcinoma (HCC) accounts for most of primary liver cancer, of which five-year survival rate remains low and chemoprevention has become a strategy to reduce disease burden of HCC. We aim to explore the in vivo chemopreventive effect of
Externí odkaz:
https://doaj.org/article/776654f455cf4d5a80e1e70f5ae5d8fe
Publikováno v:
Cell Reports, Vol 9, Iss 3, Pp 967-982 (2014)
Host cell factor-1 (HCF-1) is a metazoan transcriptional coregulator essential for cell-cycle progression and cell proliferation. Current models suggest a mechanism whereby HCF-1 functions as a direct coregulator of E2F proteins, facilitating the exp
Externí odkaz:
https://doaj.org/article/070110dd001748ab9373a1cf238f81c6
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Hepatic cancer is often amenable to surgery, including percutaneous ablation, trans-arterial chemoembolization. However, in metastatic cases, surgery is often not an effective option. Chemotherapy as a conventional clinical method for treatment of ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e03524e125e1a316c69b80991ec0f2
https://doaj.org/article/ea2342db5ee242668d9b3e5263a5e4c3
https://doaj.org/article/ea2342db5ee242668d9b3e5263a5e4c3
Autor:
Dafang Zhong, Qianqian Tian, Jinfang Jiang, Hanwei Yin, Yifan Zhang, Yilin Li, Ping Wu, Chao Peng, Zhijie Wang, Jialan Zhou, Huihui Zeng
Publikováno v:
Current drug metabolism. 23(11)
Background: Butaselen is an ebselen analog that is under clinical trials for treating hepatic and pulmonary fibrosis. Our previous studies showed that butaselen is mainly present in human plasma in the form of M2, a free Se-methylated metabolite. Obj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7469a02c6e156904a0effb8e716d7ee0
https://pubmed.ncbi.nlm.nih.gov/35619304
https://pubmed.ncbi.nlm.nih.gov/35619304