Targeting Troponin C with Small Molecules Containing Diphenyl Moieties: Calcium Sensitivity Effects on Striated Muscle and Structure Activity Relationship.

Autor: Hantz ER; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, 43210., Tikunova SB; Davis Heart and Lung Research Institute and Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, 43210., Belevych N; Division of Biosciences, College of Dentistry, The Ohio State University, Columbus, OH 43210., Davis JP; Davis Heart and Lung Research Institute and Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, 43210., Reiser PJ; Division of Biosciences, College of Dentistry, The Ohio State University, Columbus, OH 43210., Lindert S; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, 43210.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Feb 06. Date of Electronic Publication: 2023 Feb 06.

The effect of Mg ²⁺ on Ca ²⁺ binding to cardiac troponin C in hypertrophic cardiomyopathy associated TNNC1 variants.

Autor: Rayani K; Molecular Cardiac Physiology Group, Simon Fraser University, Burnaby, Canada., Hantz ER; Department of Chemistry and Biochemistry, Ohio State University, Columbus, OH, USA., Haji-Ghassemi O; Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, Canada., Li AY; Molecular Cardiac Physiology Group, Simon Fraser University, Burnaby, Canada., Spuches AM; Department of Chemistry, 300 Science and Technology, East Carolina University, Greenville, NC, USA., Van Petegem F; Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, Canada., Solaro RJ; Department of Physiology and Biophysics and the Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, USA., Lindert S; Department of Chemistry and Biochemistry, Ohio State University, Columbus, OH, USA., Tibbits GF; Molecular Cardiac Physiology Group, Simon Fraser University, Burnaby, Canada.; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, Canada.; BC Children's Hospital Research Institute, Vancouver, Canada.

Publikováno v: The FEBS journal [FEBS J] 2022 Dec; Vol. 289 (23), pp. 7446-7465. Date of Electronic Publication: 2022 Aug 02.

Applications of machine learning in computer-aided drug discovery.

Autor: Turzo SBA; Department of Chemistry and Biochemistry, Ohio State University, Columbus, OH 43210, USA., Hantz ER; Department of Chemistry and Biochemistry, Ohio State University, Columbus, OH 43210, USA., Lindert S; Department of Chemistry and Biochemistry, Ohio State University, Columbus, OH 43210, USA.

Publikováno v: QRB discovery [QRB Discov] 2022 Sep 01; Vol. 3, pp. e14. Date of Electronic Publication: 2022 Sep 01 (Print Publication: 2022).