Zobrazeno 1 - 10
of 223
pro vyhledávání: '"Hanswalter, Zentgraf"'
Autor:
Georg Gdynia, Sven W. Sauer, Jürgen Kopitz, Dominik Fuchs, Katarina Duglova, Thorsten Ruppert, Matthias Miller, Jens Pahl, Adelheid Cerwenka, Markus Enders, Heimo Mairbäurl, Marcin M. Kamiński, Roland Penzel, Christine Zhang, Jonathan C. Fuller, Rebecca C. Wade, Axel Benner, Jenny Chang-Claude, Hermann Brenner, Michael Hoffmeister, Hanswalter Zentgraf, Peter Schirmacher, Wilfried Roth
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
HMBG1 is a protein expressed in natural killer cells and is important in immunosurveillance. In this study, the authors show that HMGB1 binds to and inhibits PKM2, resulting in a block in aerobic glycolysis and ultimately cell death.
Externí odkaz:
https://doaj.org/article/6d0982f20a704f85b9b090631aa6eb7d
Autor:
Sebastian Hoepfner, Bianca Sander, Stefan Kins, Marius Zimmermann, Ritu Rajender, Carsten Rupp, Simone Eggert, Tomas Gruebl, Hanswalter Zentgraf, Amelie Heesch
Publikováno v:
Cellular and Molecular Life Sciences
Endocytosis of the amyloid precursor protein (APP) is critical for generation of β-amyloid, aggregating in Alzheimer's disease. APP endocytosis depending on the intracellular NPTY motif is well investigated, whereas involvement of the YTSI (also ter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d64978a74942360e35c2d1071f8e76b9
https://doi.org/10.1007/s00018-020-03467-1
https://doi.org/10.1007/s00018-020-03467-1
Autor:
Angela Garding, Nupur Bhattacharya, Rainer Claus, Melanie Ruppel, Cordula Tschuch, Katharina Filarsky, Irina Idler, Manuela Zucknick, Maïwen Caudron-Herger, Christopher Oakes, Verena Fleig, Ioanna Keklikoglou, Danilo Allegra, Leticia Serra, Sudhir Thakurela, Vijay Tiwari, Dieter Weichenhan, Axel Benner, Bernhard Radlwimmer, Hanswalter Zentgraf, Stefan Wiemann, Karsten Rippe, Christoph Plass, Hartmut Döhner, Peter Lichter, Stephan Stilgenbauer, Daniel Mertens
Publikováno v:
PLoS Genetics, Vol 9, Iss 4, p e1003373 (2013)
Non-coding RNAs are much more common than previously thought. However, for the vast majority of non-coding RNAs, the cellular function remains enigmatic. The two long non-coding RNA (lncRNA) genes DLEU1 and DLEU2 map to a critical region at chromosom
Externí odkaz:
https://doaj.org/article/2ff0ec4e65934165b4eda668f80d4f11
Autor:
Mindaugas Andrulis, David Capper, Jochen Meyer, Roland Penzel, Christian Hartmann, Hanswalter Zentgraf, Andreas von Deimling
Publikováno v:
Haematologica, Vol 95, Iss 10 (2010)
Externí odkaz:
https://doaj.org/article/50889019ebc946ef872847572dea824b
Publikováno v:
Cell Cycle
Accurate mitotic spindle positioning is essential for the regulation of cell fate choices, cell size and cell position within tissues. The most prominent model of spindle positioning involves a cortical pulling mechanism, where the minus end-directed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92d4d815498da397e4d5f64bb6b20965
https://doi.org/10.4161/cc.24602
https://doi.org/10.4161/cc.24602
Autor:
Jürgen Reymann, Ursula Klingmüller, Birgit Hub, Michael Boutros, Stefanie Kuhns, Annett Neuner, Holger Erfle, Philipp Wiedemann, Kerstin Schmidt, Daniel Gilbert, Gislene Pereira, Hanswalter Zentgraf, Ricardo Carvalho
Publikováno v:
The Journal of Cell Biology
A functional screen identified MARK4 as a positive regulator of axonemal extension and ciliogenesis via its interaction with the mother centriolar protein ODF2.
Despite the critical contributions of cilia to embryonic development and human healt
Despite the critical contributions of cilia to embryonic development and human healt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a57eac3bab904a51a8503add6da36e
https://doi.org/10.1083/jcb.201206013
https://doi.org/10.1083/jcb.201206013
Autor:
Peter Schirmacher, Thorsten Ruppert, Jens Pahl, Axel Benner, Jonathan C. Fuller, Katarina Duglova, Jenny Chang-Claude, Roland Penzel, Adelheid Cerwenka, Hanswalter Zentgraf, Hermann Brenner, Heimo Mairbäurl, Michael Hoffmeister, Georg Gdynia, Marcin Kamiński, Wilfried Roth, Dominik Fuchs, Markus Enders, Rebecca C. Wade, Sven W. Sauer, Jürgen Kopitz, Matthias Miller, Christine Zhang
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The high-mobility group box 1 (HMGB1) protein has a central role in immunological antitumour defense. Here we show that natural killer cell-derived HMGB1 directly eliminates cancer cells by triggering metabolic cell death. HMGB1 allosterically inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f41d88653f9c7fa0d258f51328e81fb2
http://europepmc.org/articles/PMC4786644
http://europepmc.org/articles/PMC4786644
Publikováno v:
Cellular Microbiology. 15:227-236
Summary Foamy viruses (FVs), a unique type of retroviruses, are characterized by several unusual features in their replication strategy. FVs, common to all non-human primates and several other species, display an extremely broad tropism in vitro. Bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0280ee6104a998c045e987ff61834f4
https://doi.org/10.1111/cmi.12042
https://doi.org/10.1111/cmi.12042
Autor:
Theresa Rettig, Martha Maria Gebhard, Jens Werner, Ariane Groth, Markus W. Büchler, Vanessa Rausch, Peter Schemmer, Wolfgang Gross, Jury Gladkich, Li Liu, Anja Apel, Sabrina Labsch, Hanswalter Zentgraf, Adam Kaczorowski, Alexei V. Salnikov, Georgios Kallifatidis, Ingrid Herr
Publikováno v:
The Journal of Pathology. 227:325-335
Involvement of dysregulated autophagy in cancer growth and progression has been shown in different tumour entities, including pancreatic ductal adenocarcinoma (PDA). PDA is an extremely aggressive tumour characterized by a small population of highly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca3ff1074841077fdff7d6ae4ccb73cb
https://doi.org/10.1002/path.3994
https://doi.org/10.1002/path.3994
Autor:
Andreas R. Janecke, Solaf M. Elsayed, Francesca Fabretti, Peter Nürnberg, Ezzat Elsobky, Georg Christoph Korenke, Friederike Koerber, Klaus Addicks, Max C. Liebau, Inga Ebermann, Hanno J. Bolz, Thomas Benzing, Eugen Boltshauser, Claudia Dafinger, Hanswalter Zentgraf, Bernhard Schermer, Yorck Hellenbroich, Gudrun Nürnberg
Publikováno v:
Journal of Clinical Investigation. 121:2662-2667
Joubert syndrome (JBTS) is characterized by a specific brain malformation with various additional pathologies. It results from mutations in any one of at least 10 different genes, including NPHP1, which encodes nephrocystin-1. JBTS has been linked to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e47f1464804f653b6385bb3be1a1531b
https://doi.org/10.1172/jci43639
https://doi.org/10.1172/jci43639