Prion-like domain mediated phase separation of ARID1A promotes oncogenic potential of Ewing's sarcoma.

Autor: Kim YR; Creative Research Initiatives Center for Epigenetic Code and Diseases, School of Biological Sciences, Seoul National University, Seoul, South Korea., Joo J; Department of Biological Sciences, Korea Advanced Institute of Science & Technology, Daejeon, South Korea., Lee HJ; Interdisciplinary Program in Bioengineering, Seoul National University, Seoul, South Korea., Kim C; Interdisciplinary Program in Bioengineering, Seoul National University, Seoul, South Korea., Park JC; Research Center of Genomic Medicine Institute, Seoul National University College of Medicine, Seoul, South Korea.; Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, South Korea., Yu YS; Creative Research Initiatives Center for Epigenetic Code and Diseases, School of Biological Sciences, Seoul National University, Seoul, South Korea., Kim CR; Creative Research Initiatives Center for Epigenetic Code and Diseases, School of Biological Sciences, Seoul National University, Seoul, South Korea., Lee DH; Creative Research Initiatives Center for Epigenetic Code and Diseases, School of Biological Sciences, Seoul National University, Seoul, South Korea., Cha J; Creative Research Initiatives Center for Epigenetic Code and Diseases, School of Biological Sciences, Seoul National University, Seoul, South Korea., Kwon H; Creative Research Initiatives Center for Epigenetic Code and Diseases, School of Biological Sciences, Seoul National University, Seoul, South Korea., Hanssen KM; Hopp-Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, (A Partnership) Between DKFZ and Heidelberg University Hospital, Heidelberg, Germany., Grünewald TGP; Hopp-Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, (A Partnership) Between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany., Choi M; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea., Han I; Department of Orthopaedic Surgery, Seoul National University College of Medicine, Seoul, South Korea., Bae S; Research Center of Genomic Medicine Institute, Seoul National University College of Medicine, Seoul, South Korea.; Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, South Korea., Jung I; Department of Biological Sciences, Korea Advanced Institute of Science & Technology, Daejeon, South Korea. ijung@kaist.ac.kr., Shin Y; Interdisciplinary Program in Bioengineering, Seoul National University, Seoul, South Korea. ydshin@snu.ac.kr.; Department of Mechanical Engineering, Seoul National University, Seoul, South Korea. ydshin@snu.ac.kr., Baek SH; Creative Research Initiatives Center for Epigenetic Code and Diseases, School of Biological Sciences, Seoul National University, Seoul, South Korea. sbaek@snu.ac.kr.

Publikováno v: Nature communications [Nat Commun] 2024 Aug 03; Vol. 15 (1), pp. 6569. Date of Electronic Publication: 2024 Aug 03.

GSH facilitates the binding and inhibitory activity of novel multidrug resistance protein 1 (MRP1) modulators.

Autor: Hanssen KM; Lowy Cancer Research Centre, Children's Cancer Institute Australia, UNSW Sydney, Kensington, Australia.; School of Women's and Children's Health, UNSW Sydney, Kensington, Australia., Wheatley MS; Lowy Cancer Research Centre, Children's Cancer Institute Australia, UNSW Sydney, Kensington, Australia., Yu DMT; Lowy Cancer Research Centre, Children's Cancer Institute Australia, UNSW Sydney, Kensington, Australia.; School of Women's and Children's Health, UNSW Sydney, Kensington, Australia., Conseil G; Division of Cancer Biology and Genetics, Department of Pathology and Molecular Medicine, Queen's University Cancer Research Institute, Kingston, Canada., Norris MD; Lowy Cancer Research Centre, Children's Cancer Institute Australia, UNSW Sydney, Kensington, Australia.; University of New South Wales Centre for Childhood Cancer Research, UNSW Sydney, Kensington, Australia., Haber M; Lowy Cancer Research Centre, Children's Cancer Institute Australia, UNSW Sydney, Kensington, Australia.; School of Women's and Children's Health, UNSW Sydney, Kensington, Australia., Cole SPC; Division of Cancer Biology and Genetics, Department of Pathology and Molecular Medicine, Queen's University Cancer Research Institute, Kingston, Canada., Fletcher JI; Lowy Cancer Research Centre, Children's Cancer Institute Australia, UNSW Sydney, Kensington, Australia.; School of Women's and Children's Health, UNSW Sydney, Kensington, Australia.

Publikováno v: The FEBS journal [FEBS J] 2022 Jul; Vol. 289 (13), pp. 3854-3875. Date of Electronic Publication: 2022 Feb 08.

Targeting metabolic activity in high-risk neuroblastoma through Monocarboxylate Transporter 1 (MCT1) inhibition.

Autor: Khan A; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, 2052, Australia.; School of Medical Sciences, UNSW Sydney, Sydney, NSW, 2052, Australia., Valli E; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, 2052, Australia.; School of Women's and Children's Health, UNSW Sydney, Sydney, NSW, 2052, Australia., Lam H; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, 2052, Australia.; School of Medical Sciences, UNSW Sydney, Sydney, NSW, 2052, Australia., Scott DA; Cancer Metabolism Core, Sanford-Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA., Murray J; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, 2052, Australia., Hanssen KM; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, 2052, Australia.; School of Women's and Children's Health, UNSW Sydney, Sydney, NSW, 2052, Australia., Eden G; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, 2052, Australia., Gamble LD; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, 2052, Australia., Pandher R; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, 2052, Australia., Flemming CL; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, 2052, Australia., Allan S; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, 2052, Australia., Osterman AL; Cancer Metabolism Core, Sanford-Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA., Haber M; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, 2052, Australia., Norris MD; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, 2052, Australia.; University of New South Wales Centre for Childhood Cancer Research, Sydney, NSW, Australia., Fletcher JI; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, 2052, Australia. JFletcher@ccia.unsw.edu.au.; School of Women's and Children's Health, UNSW Sydney, Sydney, NSW, 2052, Australia. JFletcher@ccia.unsw.edu.au., Yu DMT; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, 2052, Australia. DYu@ccia.unsw.edu.au.; School of Women's and Children's Health, UNSW Sydney, Sydney, NSW, 2052, Australia. DYu@ccia.unsw.edu.au.

Publikováno v: Oncogene [Oncogene] 2020 Apr; Vol. 39 (17), pp. 3555-3570. Date of Electronic Publication: 2020 Mar 02.

Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma.

Autor: Gamble LD; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Australia, PO Box 81, Randwick, NSW 2031, Australia., Purgato S; Department of Pharmacy and Biotechnology, University of Bologna, Bologna, 40126, Italy., Murray J; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Australia, PO Box 81, Randwick, NSW 2031, Australia., Xiao L; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Australia, PO Box 81, Randwick, NSW 2031, Australia., Yu DMT; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Australia, PO Box 81, Randwick, NSW 2031, Australia.; School of Women's & Children's Health, UNSW Australia, Randwick, NSW 2052, Australia., Hanssen KM; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Australia, PO Box 81, Randwick, NSW 2031, Australia.; School of Women's & Children's Health, UNSW Australia, Randwick, NSW 2052, Australia., Giorgi FM; Department of Pharmacy and Biotechnology, University of Bologna, Bologna, 40126, Italy., Carter DR; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Australia, PO Box 81, Randwick, NSW 2031, Australia.; School of Women's & Children's Health, UNSW Australia, Randwick, NSW 2052, Australia.; School of Biomedical Engineering, University of Technology, Sydney, NSW 2007, Australia., Gifford AJ; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Australia, PO Box 81, Randwick, NSW 2031, Australia.; School of Women's & Children's Health, UNSW Australia, Randwick, NSW 2052, Australia.; Department of Anatomical Pathology (SEALS), Prince of Wales Hospital, Randwick, NSW 2031, Australia., Valli E; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Australia, PO Box 81, Randwick, NSW 2031, Australia.; School of Women's & Children's Health, UNSW Australia, Randwick, NSW 2052, Australia., Milazzo G; Department of Pharmacy and Biotechnology, University of Bologna, Bologna, 40126, Italy., Kamili A; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Australia, PO Box 81, Randwick, NSW 2031, Australia.; School of Women's & Children's Health, UNSW Australia, Randwick, NSW 2052, Australia., Mayoh C; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Australia, PO Box 81, Randwick, NSW 2031, Australia.; School of Women's & Children's Health, UNSW Australia, Randwick, NSW 2052, Australia., Liu B; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Australia, PO Box 81, Randwick, NSW 2031, Australia., Eden G; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Australia, PO Box 81, Randwick, NSW 2031, Australia., Sarraf S; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Australia, PO Box 81, Randwick, NSW 2031, Australia., Allan S; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Australia, PO Box 81, Randwick, NSW 2031, Australia., Di Giacomo S; Department of Pharmacy and Biotechnology, University of Bologna, Bologna, 40126, Italy., Flemming CL; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Australia, PO Box 81, Randwick, NSW 2031, Australia., Russell AJ; Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia., Cheung BB; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Australia, PO Box 81, Randwick, NSW 2031, Australia.; School of Women's & Children's Health, UNSW Australia, Randwick, NSW 2052, Australia., Oberthuer A; Children's Hospital, Department of Pediatric Oncology and Hematology, University of Cologne, Kerpener Strasse 62, D-50924 Cologne, Germany., London WB; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA 02215, USA., Fischer M; Children's Hospital, Department of Pediatric Oncology and Hematology, University of Cologne, Kerpener Strasse 62, D-50924 Cologne, Germany., Trahair TN; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Australia, PO Box 81, Randwick, NSW 2031, Australia.; School of Women's & Children's Health, UNSW Australia, Randwick, NSW 2052, Australia.; Kids Cancer Centre, Sydney Children's Hospital, High Street, Randwick, NSW 2031, Australia., Fletcher JI; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Australia, PO Box 81, Randwick, NSW 2031, Australia.; School of Women's & Children's Health, UNSW Australia, Randwick, NSW 2052, Australia., Marshall GM; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Australia, PO Box 81, Randwick, NSW 2031, Australia.; School of Women's & Children's Health, UNSW Australia, Randwick, NSW 2052, Australia.; Kids Cancer Centre, Sydney Children's Hospital, High Street, Randwick, NSW 2031, Australia., Ziegler DS; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Australia, PO Box 81, Randwick, NSW 2031, Australia.; School of Women's & Children's Health, UNSW Australia, Randwick, NSW 2052, Australia.; Kids Cancer Centre, Sydney Children's Hospital, High Street, Randwick, NSW 2031, Australia., Hogarty MD; Division of Oncology, Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104-4318, USA., Burns MR; Aminex Therapeutics, Aminex Therapeutics Inc., Kirkland, WA 98034, USA., Perini G; Department of Pharmacy and Biotechnology, University of Bologna, Bologna, 40126, Italy., Norris MD; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Australia, PO Box 81, Randwick, NSW 2031, Australia.; University of New South Wales Centre for Childhood Cancer Research, Sydney, NSW 2052, Australia., Haber M; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Australia, PO Box 81, Randwick, NSW 2031, Australia. mhaber@ccia.unsw.edu.au.; School of Women's & Children's Health, UNSW Australia, Randwick, NSW 2052, Australia.

Publikováno v: Science translational medicine [Sci Transl Med] 2019 Jan 30; Vol. 11 (477).