Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Hansruedi Büeler"'
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Mitochondrial metabolism and dynamics (fission and fusion) critically regulate cell survival and proliferation, and abnormalities in these pathways are implicated in both neurodegenerative disorders and cancer. Mitochondrial fission is necessary for
Externí odkaz:
https://doaj.org/article/3b0acb78a3b549afa4048adf28707edb
Autor:
Hansruedi Büeler
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7, p 3342 (2021)
Adult neurogenesis is a highly regulated process during which new neurons are generated from neural stem cells in two discrete regions of the adult brain: the subventricular zone of the lateral ventricle and the subgranular zone of the dentate gyrus
Externí odkaz:
https://doaj.org/article/835ff37ef0eb4f1bbda130917af4bbba
PINK1 enhances insulin-like growth factor-1-dependent Akt signaling and protection against apoptosis
Publikováno v:
Neurobiology of Disease, Vol 45, Iss 1, Pp 469-478 (2012)
Mutations in the PARK6 gene coding for PTEN-induced kinase 1 (PINK1) cause recessive early-onset Parkinsonism. Although PINK1 and Parkin promote the degradation of depolarized mitochondria in cultured cells, little is known about changes in signaling
Externí odkaz:
https://doaj.org/article/1f4a8f99653b43d99d3ac0e26cea65fb
Publikováno v:
Neurobiology of Disease, Vol 40, Iss 1, Pp 82-92 (2010)
The mechanisms underlying neuron death in Parkinson's disease are unknown, but both genetic defects and environmental factors are implicated in its pathogenesis. Mutations in the parkin gene lead to autosomal recessive juvenile Parkinsonism (AR-JP).
Externí odkaz:
https://doaj.org/article/ab17fd0d8b4e448f8226ea2646c4b62d
Autor:
Gonzalo Sanchez, Rafael K Varaschin, Hansruedi Büeler, Paul C Marcogliese, David S Park, Louis-Eric Trudeau
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94826 (2014)
Parkinson's disease (PD) is one of the most prevalent neurodegenerative brain diseases; it is accompanied by extensive loss of dopamine (DA) neurons of the substantia nigra that project to the putamen, leading to impaired motor functions. Several gen
Externí odkaz:
https://doaj.org/article/338cbbc2bfbc4d46901edc1a04c733d1
Autor:
Ravi S Akundi, Zhenyu Huang, Joshua Eason, Jignesh D Pandya, Lianteng Zhi, Wayne A Cass, Patrick G Sullivan, Hansruedi Büeler
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16038 (2011)
PTEN-induced kinase 1 (PINK1) is linked to recessive Parkinsonism (EOPD). Pink1 deletion results in impaired dopamine (DA) release and decreased mitochondrial respiration in the striatum of mice. To reveal additional mechanisms of Pink1-related dopam
Externí odkaz:
https://doaj.org/article/32effe2afdeb4ba387466e8ffa6afed5
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Scientific Reports
Scientific Reports
Neuroinflammation is involved in the pathogenesis of Parkinson’s disease (PD) and other neurodegenerative disorders. We show that lack of PINK1- a mitochondrial kinase linked to recessive familial PD – leads to glia type-specific abnormalities of
Publikováno v:
The FASEB Journal. 31:2839-2853
Emerging evidence suggests that mitochondrial dynamics regulates adult hippocampal neurogenesis (AHN). Although abnormal AHN has been linked to depression, anxiety, and cognitive dysfunction, which are features of neurodegenerative conditions, includ
Autor:
Liuke Sun, Hansruedi Büeler
Publikováno v:
Biochemical and biophysical research communications. 517(2)
Mutations of PTEN-induced kinase 1 (PINK1) cause recessive familial Parkinson's disease. Cells lacking PINK1 display mitochondrial deficits and increased sensitivity to oxidative and proteasomal stress. It has been shown that the 52-kDa (mature) form
Autor:
Benjamin K. Yee, Lianteng Zhi, Hansruedi Büeler, Wayne A. Cass, Liuke Sun, Ruifang Shen, Sandeep Kumar Agnihotri, Marilyn J. Duncan, Ravi Shankar Akundi
Publikováno v:
Behavioural brain research. 363
Parkinson's disease (PD) is characterized by motor impairments and several non-motor features, including frequent depression and anxiety. Stress-induced deficits of adult hippocampal neurogenesis (AHN) have been linked with abnormal affective behavio