Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Hanspeter Goldschmidt"'
Autor:
Nadine Schäuble, Helmut Remschmidt, Wolfgang Siegfried, Frank Geller, Anke Hinney, Hanspeter Goldschmidt, Johannes Hebebrand
Publikováno v:
Experimental and Clinical Endocrinology & Diabetes. 111:73-76
Recently, an association between obesity and the G-allele of the -866G/A polymorphism in the promoter region of uncoupling protein-2 gene (UCP2) was reported. Both allele frequencies and genotype distributions for this polymorphism differed between o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47bc7ba06e37b439b6efdab1a00bffca
https://doi.org/10.1055/s-2003-39232
https://doi.org/10.1055/s-2003-39232
Autor:
Frank Oeffner, T Görg, Dorothea Bornholdt, Alan F. Wright, Wolfgang Siegfried, Hanspeter Goldschmidt, Karl-Heinz Grzeschik, Johannes Hebebrand, Anke Hinney, G Gerber, Andreas Ziegler
Publikováno v:
Acta Diabetologica. 37:93-101
Neuromedin B has been shown to exert an inhibiting effect on food consumption in rats. The corresponding gene NMB maps to chromosome 15q22.3-q23, a region expected to contain a gene for the Bardet-Biedl syndrome type 4 (BBS4). Based on its map positi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df32daaa659c5b40be691556fe0a3ffe
https://doi.org/10.1007/s005920070026
https://doi.org/10.1007/s005920070026
Autor:
Anke Hinney, Andreas Ziegler, H. Roth, Tina Korn, Frank Oeffner, Karl-Heinz Grzeschik, Wolfgang Siegfried, Johannes Hebebrand, Hanspeter Goldschmidt
Publikováno v:
International Journal of Obesity. 25:767-769
BACKGROUND: NDN, which codes for the human necdin protein, is a candidate gene for Prader–Willi syndrome (PWS). One feature of this neurogenetic disorder is hyperphagia resulting in extreme obesity observed later in development. OBJECTIVE AND DESIG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f1f5ce25e0f0fafd3676797a52e37a3
https://doi.org/10.1038/sj.ijo.0801626
https://doi.org/10.1038/sj.ijo.0801626
Autor:
Wolfgang Siegfried, Kathrin Reichwald, Beate Herpertz-Dahlmann, Frank Geller, Martin Linder, Johannes Hebebrand, U. Hemminger, Hanspeter Goldschmidt, J. Smidt, Susann Friedel, Astrid Dempfle, G. Brönner, Andreas Warnke, Anke Hinney, Helmut Remschmidt, Anne-Kathrin Wermter, H. Kiefl, F. Fontenla Horro, Kerstin Konrad
Several lines of evidence indicate an involvement of brain derived neurotrophic factor (BDNF) in body weight regulation and activity: heterozygous Bdnf knockout mice (Bdnf+/−) are hyperphagic, obese, and hyperactive; furthermore, central infusion o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b557580fec748b9953246ecba588c7b
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=19944429689
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=19944429689
Autor:
Frank Geller, John E. Blundell, Kathrin Reichwald, Gerald Preibisch, Anke Hinney, Matthias Platzer, Heiko Krude, Thomas Gudermann, Hanspeter Goldschmidt, Oluf Pedersen, Karine Clément, H-Erich Wichmann, Claudia Hess, Weidong Li, Klaus Huse, Martin Wabitsch, Lesli H. Larsen, Helmut Schäfer, Arne Astrup, Cornelia Platzer, Anne-Kathrin Wermter, Heike Biebermann, Thorkild I. A. Sørensen, Johannes Hebebrand, Thomas Illig, R. Arlen Price, Thomas R. H. Büch, Caren Vollmert, Helmut Remschmidt, Delphine Eberlé, Wolfgang Siegfried
Publikováno v:
Eur. J. Endocrinol. 152, 851-862 (2005)
Objective: The importance of the melanin-concentrating hormone (MCH) system for regulation of energy homeostasis and body weight has been demonstrated in rodents. We analysed the human MCH receptor 1 gene (MCHR1) with respect to human obesity.Design:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2a7af7bea2a43bcbdd7181c164b9b4f
https://www.ncbi.nlm.nih.gov/pubmed/15941924
https://www.ncbi.nlm.nih.gov/pubmed/15941924
Autor:
Helmut Remschmidt, Frank Geller, Anne-Kathrin Wermter, Britta Brokamp, Hanspeter Goldschmidt, Constanze Vogel, Johannes Hebebrand, Thomas Gudermann, Anke Hinney, Claudia Hess, Sarah Hohmann, Helmut Schäfer, Wolfgang Siegfried
Publikováno v:
The Journal of clinical endocrinology and metabolism. 88(9)
We initially performed a mutation screen of the coding region of the MC4R in 808 extremely obese children and adolescents and 327 underweight or normal-weight controls allowing for a case-control study. A total of 16 different missense, nonsense, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::273db81e93c69e668bf263fdbbb968fa
https://pubmed.ncbi.nlm.nih.gov/12970296
https://pubmed.ncbi.nlm.nih.gov/12970296
Autor:
Helmut Remschmidt, Wolfgang Siegfried, André Reis, Frank Geller, Andreas Ziegler, Kathrin Saar, Hanspeter Goldschmidt, Johannes Hebebrand, Peter Nürnberg, Franz Rüschendorf, Anke Hinney, Susann Friedel, Helmut Schäfer, Nadine Schäuble
Publikováno v:
Pediatrics. 111(2)
Objective. Several genome scans have been performed for adult obesity. Because single formal genetic studies suggest a higher heritability of body weight in adolescence and because genes that influence body weight in adulthood might not be the same a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd8bfc2ec6c144006db3743d9de1487f
https://pubmed.ncbi.nlm.nih.gov/12563058
https://pubmed.ncbi.nlm.nih.gov/12563058
Autor:
Helmut Remschmidt, Anke Hinney, Frank Geller, Benjamin Antwerpen, Helmut Schäfer, Johannes Hebebrand, Wolfgang Siegfried, Hanspeter Goldschmidt, Andreas Ziegler
Publikováno v:
Molecular genetics and metabolism. 76(2)
In light of evidence of linkage of obesity to chromosome 2q31-q37, we hypothesized that the calpain-10 gene 'high-risk' haplotype combination for non-insulin-dependent diabetes mellitus (NIDDM) is involved in early onset obesity. We screened the NIDD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb46db52e799a13fc81aa212306164c
https://pubmed.ncbi.nlm.nih.gov/12083814
https://pubmed.ncbi.nlm.nih.gov/12083814
Autor:
Wolfgang Siegfried, Christine Wedewardt, Frank Geller, Andreas Ziegler, Frank Oeffner, Helmut Remschmidt, Heiko Wulftange, Kurt Stübing, Markus Vogel, Anke Hinney, Hanspeter Goldschmidt, Johannes Hebebrand
Publikováno v:
The Journal of clinical endocrinology and metabolism. 85(8)
Linkage results obtained in genome-wide scans for complex phenotypes require confirmation in independent samples. Recently, linkage of obesity to chromosome 10p12 with a maximal multipoint LOD score of 4.85 was reported upon use of an affected sib-pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb75d322d44217aad89b45134ab88ea6
https://pubmed.ncbi.nlm.nih.gov/10946912
https://pubmed.ncbi.nlm.nih.gov/10946912
Autor:
Wolfgang Siegfried, Helmut Schäfer, Anke Hinney, Helmut Remschmidt, Frank Geller, Johannes Hebebrand, Hanspeter Goldschmidt, Anne Hoch
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 87:2716-2716
Ghrelin induces obesity via central and peripheral mechanisms. Administration of ghrelin leads to increased food intake and decreased fat utilisation in rodents. Ghrelin levels are decreased in obese individuals. Recently, a polymorphism (Arg-51-Gln)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bf6225266e175134c85f2b7227a1387
https://doi.org/10.1210/jcem.87.6.8672
https://doi.org/10.1210/jcem.87.6.8672