Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Hanspeter Goldschmidt"'
Autor:
Nadine Schäuble, Helmut Remschmidt, Wolfgang Siegfried, Frank Geller, Anke Hinney, Hanspeter Goldschmidt, Johannes Hebebrand
Publikováno v:
Experimental and Clinical Endocrinology & Diabetes. 111:73-76
Recently, an association between obesity and the G-allele of the -866G/A polymorphism in the promoter region of uncoupling protein-2 gene (UCP2) was reported. Both allele frequencies and genotype distributions for this polymorphism differed between o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47bc7ba06e37b439b6efdab1a00bffca
https://doi.org/10.1055/s-2003-39232
https://doi.org/10.1055/s-2003-39232
Autor:
Frank Oeffner, T Görg, Dorothea Bornholdt, Alan F. Wright, Wolfgang Siegfried, Hanspeter Goldschmidt, Karl-Heinz Grzeschik, Johannes Hebebrand, Anke Hinney, G Gerber, Andreas Ziegler
Publikováno v:
Acta Diabetologica. 37:93-101
Neuromedin B has been shown to exert an inhibiting effect on food consumption in rats. The corresponding gene NMB maps to chromosome 15q22.3-q23, a region expected to contain a gene for the Bardet-Biedl syndrome type 4 (BBS4). Based on its map positi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df32daaa659c5b40be691556fe0a3ffe
https://doi.org/10.1007/s005920070026
https://doi.org/10.1007/s005920070026
Autor:
Anke Hinney, Andreas Ziegler, H. Roth, Tina Korn, Frank Oeffner, Karl-Heinz Grzeschik, Wolfgang Siegfried, Johannes Hebebrand, Hanspeter Goldschmidt
Publikováno v:
International Journal of Obesity. 25:767-769
BACKGROUND: NDN, which codes for the human necdin protein, is a candidate gene for Prader–Willi syndrome (PWS). One feature of this neurogenetic disorder is hyperphagia resulting in extreme obesity observed later in development. OBJECTIVE AND DESIG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f1f5ce25e0f0fafd3676797a52e37a3
https://doi.org/10.1038/sj.ijo.0801626
https://doi.org/10.1038/sj.ijo.0801626
Autor:
Johannes Hebebrand, Anke Hinney, André Scherag, Katja Hölter, Anne-Kathrin Wermter, Wolfgang Siegfried, Hanspeter Goldschmidt
Publikováno v:
BMC Medical Genetics
BMC Medical Genetics, Vol 8, Iss 1, p 21 (2007)
BMC Medical Genetics, Vol 8, Iss 1, p 21 (2007)
Background The suppressor of cytokine signaling (SOCS)-3 is a negative feedback regulator of cytokine signaling and also influences leptin signaling. We investigated association of variations in the coding sequence and promoter region of SOCS3 with e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e2d128c021c8c8fbb28a2159cf78f60
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=34248231880
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=34248231880
Autor:
Wolfgang Siegfried, Kathrin Reichwald, Beate Herpertz-Dahlmann, Frank Geller, Martin Linder, Johannes Hebebrand, U. Hemminger, Hanspeter Goldschmidt, J. Smidt, Susann Friedel, Astrid Dempfle, G. Brönner, Andreas Warnke, Anke Hinney, Helmut Remschmidt, Anne-Kathrin Wermter, H. Kiefl, F. Fontenla Horro, Kerstin Konrad
Several lines of evidence indicate an involvement of brain derived neurotrophic factor (BDNF) in body weight regulation and activity: heterozygous Bdnf knockout mice (Bdnf+/−) are hyperphagic, obese, and hyperactive; furthermore, central infusion o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b557580fec748b9953246ecba588c7b
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=19944429689
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=19944429689
Autor:
Frank Geller, John E. Blundell, Kathrin Reichwald, Gerald Preibisch, Anke Hinney, Matthias Platzer, Heiko Krude, Thomas Gudermann, Hanspeter Goldschmidt, Oluf Pedersen, Karine Clément, H-Erich Wichmann, Claudia Hess, Weidong Li, Klaus Huse, Martin Wabitsch, Lesli H. Larsen, Helmut Schäfer, Arne Astrup, Cornelia Platzer, Anne-Kathrin Wermter, Heike Biebermann, Thorkild I. A. Sørensen, Johannes Hebebrand, Thomas Illig, R. Arlen Price, Thomas R. H. Büch, Caren Vollmert, Helmut Remschmidt, Delphine Eberlé, Wolfgang Siegfried
Publikováno v:
Eur. J. Endocrinol. 152, 851-862 (2005)
Objective: The importance of the melanin-concentrating hormone (MCH) system for regulation of energy homeostasis and body weight has been demonstrated in rodents. We analysed the human MCH receptor 1 gene (MCHR1) with respect to human obesity.Design:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2a7af7bea2a43bcbdd7181c164b9b4f
https://www.ncbi.nlm.nih.gov/pubmed/15941924
https://www.ncbi.nlm.nih.gov/pubmed/15941924
Autor:
Helmut Remschmidt, Frank Geller, Anne-Kathrin Wermter, Britta Brokamp, Hanspeter Goldschmidt, Constanze Vogel, Johannes Hebebrand, Thomas Gudermann, Anke Hinney, Claudia Hess, Sarah Hohmann, Helmut Schäfer, Wolfgang Siegfried
Publikováno v:
The Journal of clinical endocrinology and metabolism. 88(9)
We initially performed a mutation screen of the coding region of the MC4R in 808 extremely obese children and adolescents and 327 underweight or normal-weight controls allowing for a case-control study. A total of 16 different missense, nonsense, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::273db81e93c69e668bf263fdbbb968fa
https://pubmed.ncbi.nlm.nih.gov/12970296
https://pubmed.ncbi.nlm.nih.gov/12970296
Autor:
Helmut Remschmidt, Wolfgang Siegfried, André Reis, Frank Geller, Andreas Ziegler, Kathrin Saar, Hanspeter Goldschmidt, Johannes Hebebrand, Peter Nürnberg, Franz Rüschendorf, Anke Hinney, Susann Friedel, Helmut Schäfer, Nadine Schäuble
Publikováno v:
Pediatrics. 111(2)
Objective. Several genome scans have been performed for adult obesity. Because single formal genetic studies suggest a higher heritability of body weight in adolescence and because genes that influence body weight in adulthood might not be the same a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd8bfc2ec6c144006db3743d9de1487f
https://pubmed.ncbi.nlm.nih.gov/12563058
https://pubmed.ncbi.nlm.nih.gov/12563058
Autor:
Helmut Remschmidt, Anke Hinney, Frank Geller, Benjamin Antwerpen, Helmut Schäfer, Johannes Hebebrand, Wolfgang Siegfried, Hanspeter Goldschmidt, Andreas Ziegler
Publikováno v:
Molecular genetics and metabolism. 76(2)
In light of evidence of linkage of obesity to chromosome 2q31-q37, we hypothesized that the calpain-10 gene 'high-risk' haplotype combination for non-insulin-dependent diabetes mellitus (NIDDM) is involved in early onset obesity. We screened the NIDD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb46db52e799a13fc81aa212306164c
https://pubmed.ncbi.nlm.nih.gov/12083814
https://pubmed.ncbi.nlm.nih.gov/12083814
Autor:
Wolfgang Siegfried, Christine Wedewardt, Frank Geller, Andreas Ziegler, Frank Oeffner, Helmut Remschmidt, Heiko Wulftange, Kurt Stübing, Markus Vogel, Anke Hinney, Hanspeter Goldschmidt, Johannes Hebebrand
Publikováno v:
The Journal of clinical endocrinology and metabolism. 85(8)
Linkage results obtained in genome-wide scans for complex phenotypes require confirmation in independent samples. Recently, linkage of obesity to chromosome 10p12 with a maximal multipoint LOD score of 4.85 was reported upon use of an affected sib-pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb75d322d44217aad89b45134ab88ea6
https://pubmed.ncbi.nlm.nih.gov/10946912
https://pubmed.ncbi.nlm.nih.gov/10946912