Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Hanson Smith"'
Autor:
Araks Martirosyan, Rizwan Ansari, Francisco Pestana, Katja Hebestreit, Hayk Gasparyan, Razmik Aleksanyan, Silvia Hnatova, Suresh Poovathingal, Catherine Marneffe, Dietmar R. Thal, Andrew Kottick, Victor J. Hanson-Smith, Sebastian Guelfi, William Plumbly, T. Grant Belgard, Emmanouil Metzakopian, Matthew G. Holt
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-24 (2024)
Abstract Parkinson’s Disease (PD) is the second most common neurodegenerative disorder. The pathological hallmark of PD is loss of dopaminergic neurons and the presence of aggregated α-synuclein, primarily in the substantia nigra pars compacta (SN
Externí odkaz:
https://doaj.org/article/ac5a812e7fc64915b2e68e33cecdd4a4
Autor:
Araks Martirosyan, Rizwan Ansari, Francisco Pestana, Katja Hebestreit, Hayk Gasparyan, Razmik Aleksanyan, Silvia Hnatova, Suresh Poovathingal, Catherine Marneffe, Dietmar R. Thal, Andrew Kottick, Victor J. Hanson-Smith, Sebastian Guelfi, William Plumbly, T. Grant Belgard, Emmanouil Metzakopian, Matthew G. Holt
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/5bf4088beae54ac38e53d043a1ffdfc6
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Despite the recent precipitous decline in the cost of genome sequencing, library preparation for RNA-seq is still laborious and expensive for applications such as high throughput screening. Limited availability of RNA generated by some exper
Externí odkaz:
https://doaj.org/article/d7a294302a16493083fff29d588ced7f
Akademický článek
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A central challenge in the study of protein evolution is the identification of historic amino acid sequence changes responsible for creating novel functions observed in present-day proteins. To address this problem, we developed a new method to ident
Externí odkaz:
http://arxiv.org/abs/1406.3067
Autor:
Julie Takagi, Christina Cho, Angela Duvalyan, Yao Yan, Megan Halloran, Victor Hanson-Smith, Jeremy Thorner, Gregory C Finnigan
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 1 (2020)
AbstractSeptins are GTP-binding proteins conserved across metazoans. They can polymerize into extended filaments and, hence, are considered a component of the cytoskeleton. The number of individual septins varies across the tree of life—yeast (Sacc
Externí odkaz:
https://doaj.org/article/44920815e48b4783a9815deb8900df6d
Autor:
David Lamparter, Rajat Bhatnagar, Katja Hebestreit, T Grant Belgard, Alice Zhang, Victor Hanson-Smith
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 6, p e1007770 (2020)
A longstanding goal of regulatory genetics is to understand how variants in genome sequences lead to changes in gene expression. Here we present a method named Bayesian Annotation Guided eQTL Analysis (BAGEA), a variational Bayes framework to model c
Externí odkaz:
https://doaj.org/article/b49618ed04a2439eb6a5b66f1191dc55
Autor:
Araks Martirosyan, Francisco Pestana, Katja Hebestreit, Hayk Gasparyan, Razmik Aleksanyan, Suresh Poovathingal, Catherine Marneffe, Dietmar R. Thal, Andrew Kottick, Victor Hanson-Smith, Sebastian Guelfi, Emmanouil Metzakopian, T. Grant Belgard
Parkinson’s Disease (PD) is the second most common neurodegenerative disorder and is generally characterized by impaired motor functions. It currently affects 6.3 million people aged 60 years and more, worldwide. The pathological hallmarks of PD ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4bfedce228d2dbb5d7bb0c8f112ae5e
https://doi.org/10.1101/2023.01.04.522691
https://doi.org/10.1101/2023.01.04.522691
Autor:
A. Gómez-Pascual, A. Martirosyan, K. Hebestreit, C. Mameffe, S. Poovathingal, T. G. Belgard, C. A. Altar, A. Kottick, M. Holt, V. Hanson-Smith, A. Cisterna, M. Mighdoll, R. Scannevin, S. Guelfi, J. A. Botía
Motivationgene co-expression networks have been widely applied to identify critical genes and pathways for neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease. Now, with the advent of single-cell RNA-sequencing, we have the opp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4169d1c2385976f1180a35a975029b9
https://doi.org/10.1101/2022.12.13.514863
https://doi.org/10.1101/2022.12.13.514863
Autor:
Hanson Smith
Publikováno v:
Acta Arithmetica. 198:313-327
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae607aeef5d7b8e196947e58c6e83ee4
https://doi.org/10.4064/aa200811-7-10
https://doi.org/10.4064/aa200811-7-10