Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Hansjorg Hauser"'
Autor:
Yesenia Latorre, Mauro Torres, Mauricio Vergara, Julio Berrios, Maria Molina Sampayo, Natasha Gödecke, Dagmar Wirth, Hansjörg Hauser, Alan J. Dickson, Claudia Altamirano
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Improving the cellular capacity of Chinese hamster ovary (CHO) cells to produce large amounts of therapeutic proteins remains a major challenge for the biopharmaceutical industry. In previous studies, we observed strong correlations between
Externí odkaz:
https://doaj.org/article/87bd9622de584d6fbc8632649eabc4b1
Autor:
Wilfried A. Kues, Reinhard Schwinzer, Dagmar Wirth, Els Verhoeyen, Erika Lemme, Doris Herrmann, Brigitte Barg-Kues, Hansjörg Hauser, Kurt Wonigeit, Heiner Niemann, Hansjorg Hauser
Publikováno v:
The FASEB Journal. 20:1200-1202
The applicability of tightly regulated transgenesis in domesticated animals is severely hampered by the present lack of knowledge of regulatory mechanisms and the long generation intervals. To capitalize on the tightly controlled expression of mammal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b3ae4c2b28a21c5a6200c76f5118a90
https://doi.org/10.1096/fj.05-5415fje
https://doi.org/10.1096/fj.05-5415fje
Autor:
Johannes Schwerk, Lucas Kemper, Kendra A. Bussey, Stefan Lienenklaus, Siegfried Weiss, Luka Čičin-Šain, Andrea Kröger, Ulrich Kalinke, Christopher M. Collins, Samuel H. Speck, Martin Messerle, Dagmar Wirth, Melanie M. Brinkmann, Hansjörg Hauser, Mario Köster
Publikováno v:
Pathogens, Vol 11, Iss 12, p 1554 (2022)
Gammaherpesviruses, such as Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus, are important human pathogens involved in lymphoproliferative disorders and tumorigenesis. Herpesvirus infections are characterized by a biphasic cycle comp
Externí odkaz:
https://doaj.org/article/2db1caf9db6a4ebcb475422ae96a09da
Autor:
Christoph Lipps, Franziska Klein, Tom Wahlicht, Virginia Seiffert, Milada Butueva, Jeannette Zauers, Theresa Truschel, Martin Luckner, Mario Köster, Roderick MacLeod, Jörn Pezoldt, Jochen Hühn, Qinggong Yuan, Peter Paul Müller, Henning Kempf, Robert Zweigerdt, Oliver Dittrich-Breiholz, Thomas Pufe, Rainer Beckmann, Wolf Drescher, Jose Riancho, Carolina Sañudo, Thomas Korff, Bertram Opalka, Vera Rebmann, Joachim R. Göthert, Paula M. Alves, Michael Ott, Roland Schucht, Hansjörg Hauser, Dagmar Wirth, Tobias May
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Personalised medicine requires cell cultures from defined genetic backgrounds, but providing sufficient numbers of cells is a challenge. Here the authors develop gene cocktails to expand primary cells from a variety of different tissues and species,
Externí odkaz:
https://doaj.org/article/e9ef9c4a20664d78b68d4039733b3449
Autor:
Tanja Laske, Mandy Bachmann, Melanie Dostert, Alexander Karlas, Dagmar Wirth, Timo Frensing, Thomas F Meyer, Hansjörg Hauser, Udo Reichl
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 4, p e1006944 (2019)
The best measure to limit spread of contagious diseases caused by influenza A viruses (IAVs) is annual vaccination. The growing global demand for low-cost vaccines requires the establishment of high-yield production processes. One possible option to
Externí odkaz:
https://doaj.org/article/c71c0dbbd2104a86a7fd157818081019
Autor:
Tharini A. Selvakumar, Sudeep Bhushal, Ulrich Kalinke, Dagmar Wirth, Hansjörg Hauser, Mario Köster, Mathias W. Hornef
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Type I (α and β) and type III (λ) interferons (IFNs) induce the expression of a large set of antiviral effector molecules via their respective surface membrane receptors. Whereas most cell types respond to type I IFN, type III IFN preferentially a
Externí odkaz:
https://doaj.org/article/8ae5a5feb2a548f4a4ae27e5aa0cf706
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Intrapulmonary immune reactions are impaired by the tolerogenic environment of the lung. This is manifested by the absence of effective endogenous T cell responses upon neoantigen expression. This tolerance is considered to contribute to lung cancer
Externí odkaz:
https://doaj.org/article/c0b6f9e702b0470b9c3e5ec37e7a3fd8
Autor:
Sudeep Bhushal, Markus Wolfsmüller, Tharini A. Selvakumar, Lucas Kemper, Dagmar Wirth, Mathias W. Hornef, Hansjörg Hauser, Mario Köster
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Type I and type III interferons (IFNs) are crucial components of the first-line antiviral host response. While specific receptors for both IFN types exist, intracellular signaling shares the same Jak-STAT pathway. Due to its receptor expression, IFN-
Externí odkaz:
https://doaj.org/article/43ef5eb861eb4b8ea238ff4dbd4d25bf
Autor:
Mamduh Khateb, Nitsan Fourier, Ofer Barnea-Yizhar, Sigal Ram, Ekaterina Kovalev, Aviva Azriel, Ulfert Rand, Manabu Nakayama, Hansjörg Hauser, Lior Gepstein, Ben-Zion Levi
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156812 (2016)
Interferon Regulatory Factor-8 (IRF-8) serves as a key factor in the hierarchical differentiation towards monocyte/dendritic cell lineages. While much insight has been accumulated into the mechanisms essential for its hematopoietic specific expressio
Externí odkaz:
https://doaj.org/article/2319e96602e442bab6b33af6216f715e
Autor:
Ulfert Rand, Melanie Rinas, Johannes Schwerk, Gesa Nöhren, Melanie Linnes, Andrea Kröger, Michael Flossdorf, Kristóf Kály‐Kullai, Hansjörg Hauser, Thomas Höfer, Mario Köster
Publikováno v:
Molecular Systems Biology, Vol 8, Iss 1, Pp 1-13 (2012)
Abstract The cellular recognition of viruses evokes the secretion of type‐I interferons (IFNs) that induce an antiviral protective state. By live‐cell imaging, we show that key steps of virus‐induced signal transduction, IFN‐β expression, an
Externí odkaz:
https://doaj.org/article/7f837d2b0b1f40dcac2982f38342f341