Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Hansjörg Wiegand"'
Autor:
Maria Ines Rodriguez Perez, Gerhard Gross, Magnus Rueping, Thierry Kimmerlin, Hendrik Andres, Dieter Seebach, Alain Schweitzer, Bernard Wirz, Hansjörg Wiegand
Publikováno v:
Chemistry & Biodiversity. 1:1812-1828
The solid-phase synthesis and an ADME investigation with albino and pigmented male rats of the doubly 14C-labelled beta/alpha-tetrapeptide derivative Ac-beta3 hTyr-(D)Trp-beta3 hLys-beta3 hThr-lactone (3; Fig. 3) are described. After intravenous (i.v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0c55bcc777d8e72ae22a53487925594
https://doi.org/10.1002/cbdv.200490136
https://doi.org/10.1002/cbdv.200490136
Autor:
Francois Legay, Sonia Gauron, Christina Ravera, Fabienne Deckert, Ghislaine Gosset, Ulrike Pfaar, Hansjörg Wiegand, Horst Schran
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 30:897-911
Zoledronic acid is a new, highly potent bisphosphonate drug under clinical evaluation. A radioimmunoassay has been developed to determine zoledronic acid concentration in human serum, plasma, and urine. The assay utilizes rabbit polyclonal antisera a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95653fc8c8f2f7ec1108284c59bab439
https://doi.org/10.1016/s0731-7085(02)00218-2
https://doi.org/10.1016/s0731-7085(02)00218-2
Autor:
Bernard Wirz, Maria Ines Rodriguez Perez, Jens Frackenpohl, Ralph Woessner, Dieter Seebach, Hansjörg Wiegand, Alain Schweitzer, Gian Camenisch, R. Voges, Gerhard Gross, Per I. Arvidsson
Publikováno v:
Biopharmaceutics & Drug Disposition. 23:251-262
In vitro studies: In CaCo-2 cell monolayers the β-nonapeptide H(β-HAla-β-HLys-β-HPhe)3-OH·4HCl (1), 14C-labeled on both C atoms of the CH2–CO moiety of the central β-HPhe residue, showed a low intrinsic permeability (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf47328a724f450a43a73e848c003d4f
https://doi.org/10.1002/bdd.334
https://doi.org/10.1002/bdd.334
Autor:
Sylvain Cottens, Jürgen Wagner, Gisbert Weckbecker, Hansjörg Wiegand, Richard Sedrani, Bernard Faller, Christian Jean, Rainer Albert, Jean-Pierre Evenou, Gerhard Zenke, Nigel Graham Cooke, Peter von Matt, Christian Beerli
Publikováno v:
Journal of medicinal chemistry. 54(17)
Protein kinase C (PKC) isotypes have emerged as key targets for the blockade of early T-cell activation. Herein, we report on the structure–activity relationship and the detailed physicochemical and in vivo pharmacokinetic properties of sotrastauri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::161868ccf1e7b0c5ff4065ec6638be3f
https://pubmed.ncbi.nlm.nih.gov/21797275
https://pubmed.ncbi.nlm.nih.gov/21797275
Autor:
Thomas Faller, Hanspeter Nick, Felix Waldmeier, Gerard Bruin, Hansjörg Wiegand, Josef Schneider, K. Olaf Boernsen, Alain Schweitzer
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 36(12)
Deferasirox (Exjade, ICL670, CGP72670) is an iron-chelating drug for p.o. treatment of transfusional iron overload in patients with beta-thalassemia or sickle cell disease. The pharmacokinetics and disposition of deferasirox were investigated in rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29bc73ece40dfb2dc2ceb18fbf9fad07
https://pubmed.ncbi.nlm.nih.gov/18775980
https://pubmed.ncbi.nlm.nih.gov/18775980
Autor:
Horst Schran, Ulrike Pfaar, H. Markus Weiss, Alain Schweitzer, Andrej Skerjanec, Hansjörg Wiegand
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 36(10)
The bisphosphonate zoledronic acid is a potent inhibitor of osteoclast-mediated bone resorption. To investigate drug biodistribution and elimination, (14)C-zoledronic acid was administered intravenously to rats and dogs in single or multiple doses an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e1e211a82b4eafa5ab3b231c7ab1db3
https://pubmed.ncbi.nlm.nih.gov/18625688
https://pubmed.ncbi.nlm.nih.gov/18625688
Autor:
Hansjörg, Wiegand, Bernard, Wirz, Alain, Schweitzer, Gerhard, Gross, Maria I Rodriguez, Perez, Hendrik, Andres, Thierry, Kimmerlin, Magnus, Rueping, Dieter, Seebach
Publikováno v:
Chemistrybiodiversity. 1(11)
The solid-phase synthesis and an ADME investigation with albino and pigmented male rats of the doubly 14C-labelled beta/alpha-tetrapeptide derivative Ac-beta3 hTyr-(D)Trp-beta3 hLys-beta3 hThr-lactone (3; Fig. 3) are described. After intravenous (i.v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0599b9bbd49039b70962660a08b9f7ac
https://pubmed.ncbi.nlm.nih.gov/17191818
https://pubmed.ncbi.nlm.nih.gov/17191818