Výsledky vyhledávání - "Hansjörg, Kasper"

Optogenetically stimulating intact rat corticospinal tract post-stroke restores motor control through regionalized functional circuit formation

Autor: Martin E. Schwab, Fritjof Helmchen, Benjamin V. Ineichen, Uta Büchler, Anna-Sophia Wahl, Hansjörg Kasper, André W. Brändli, Biagio Brattoli, Björn Ommer, Simon Musall

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Nature Communications
Nature Communications, 8 (1)

Current neuromodulatory strategies to enhance motor recovery after stroke often target large brain areas non-specifically and without sufficient understanding of their interaction with internal repair mechanisms. Here we developed a novel therapeutic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa8d089e938ae7c3c1a531ee4bb4470
http://link.springer.com/article/10.1038/s41467-017-01090-6

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A novel urodynamic model for lower urinary tract assessment in awake rats

Autor: Marco Tedaldi, Laura Spruill, Hansjörg Kasper, J. Todd Purves, Martin E. Schwab, Thomas M. Kessler, Marc P. Schneider, Miriam Gullo, Francis M. Hughes, Anne K. Engmann

Publikováno v: BJU International. 115:8-15

Objectives To develop a urodynamic model incorporating external urethral sphincter (EUS) electromyography (EMG) in awake rats. Materials and Methods Bladder catheters and EUS EMG electrodes were implanted in female Sprague Dawley rats. Assessments we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9003e9585a0f58e94efa6b88a68789c1
https://doi.org/10.1111/bju.13039

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Bridging the Gap: A Reticulo-Propriospinal Detour Bypassing an Incomplete Spinal Cord Injury

Autor: Regula Schneider, Hansjörg Kasper, Oliver Weinmann, Anne K. Engmann, Timoleon Moraitis, Linard Filli, Miriam Gullo, Björn Zörner, Martin E. Schwab

Publikováno v: The Journal of Neuroscience. 34:13399-13410

Anatomically incomplete spinal cord injuries are often followed by considerable functional recovery in patients and animal models, largely because of processes of neuronal plasticity. In contrast to the corticospinal system, where sprouting of fibers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecac13b63b116dba54c15478b54bc3b3
https://doi.org/10.1523/jneurosci.0701-14.2014

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Neutralization of Nogo-A enhances synaptic plasticity in the rodent motor cortex and improves motor learning in vivo

Autor: Yves Kellner, Karin Lussi, Raul Vicente, Ajmal Zemmar, Andreas R. Luft, Oliver Weinmann, Marta Zagrebelsky, Yi Zuo, Miriam Gullo, Mengia Rioult-Pedotti, Martin E. Schwab, Hansjörg Kasper, Zorica Ristic, Xinzhu Yu

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 34, iss 26
Journal of Neuroscience

The membrane protein Nogo-A is known as an inhibitor of axonal outgrowth and regeneration in the CNS. However, its physiological functions in the normal adult CNS remain incompletely understood. Here, we investigated the role of Nogo-A in cortical sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ce1148fd9d23174cca5483bb7975fa

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High-Impact, Self-Motivated Training Within an Enriched Environment With Single Animal Tracking Dose-Dependently Promotes Motor Skill Acquisition and Functional Recovery

Autor: Frank Buschmann, Martin E. Schwab, Hansjörg Kasper, Miriam Gullo, Michelle L. Starkey, Christiane Bleul, Björn Zörner, Alice C. Mosberger, Stefan Giger

Publikováno v: Neurorehabilitation and neural repair

Functional recovery following central nervous system injuries is strongly influenced by rehabilitative training. In the clinical setting, the intensity of training and the level of motivation for a particular task are known to play important roles. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b15c1a8c486e689e6be1deacfe5f4ac4

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Synthetic microRNA-mediated downregulation of Nogo-A in transgenic rats reveals its role as regulator of synaptic plasticity and cognitive function

Autor: Mengia-Seraina Rioult-Pedotti, Hansjörg Kasper, Miriam Schneider, Kai Schönig, Stefano Clementi, Dusan Bartsch, Oliver Weinmann, Thomas Enkel, Ajmal Zemmar, Martin E. Schwab, Stefan M. Berger, Michael E. Arzt, Björn Tews

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences

We have generated a transgenic rat model using RNAi and used it to study the role of the membrane protein Nogo-A in synaptic plasticity and cognition. The membrane protein Nogo-A is expressed in CNS oligodendrocytes and subpopulations of neurons, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c2c9d764a5e463620aa8febaca68be1

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Motivational state, reward value, and Pavlovian cues differentially affect skilled forelimb grasping in rats

Autor: Hansjörg Kasper, Martin E. Schwab, Alice C. Mosberger, Larissa de Clauser

Motor skills represent high-precision movements performed at optimal speed and accuracy. Such motor skills are learned with practice over time. Besides practice, effects of motivation have also been shown to influence speed and accuracy of movements,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bc0385b352b97dba0531fade6714898
https://europepmc.org/articles/PMC4880147/

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Profiling locomotor recovery: comprehensive quantification of impairments after CNS damage in rodents

Autor: Roman Gonzenbach, Hansjörg Kasper, Martina Röthlisberger, Linard Filli, Michelle L. Starkey, Björn Zörner, Marc Bolliger, Martin E. Schwab

Publikováno v: Nature Methods. 7:701-708

Rodents are frequently used to model damage and diseases of the central nervous system (CNS) that lead to functional deficits. Impaired locomotor function is currently evaluated by using scoring systems or biomechanical measures. These methods often

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7818d28f8854fbe17c132c5c92d9541
https://doi.org/10.1038/nmeth.1484

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A novel urodynamic model for lower urinary tract assessment in awake rats

Autor: Marc P, Schneider, Francis M, Hughes, Anne K, Engmann, J Todd, Purves, Hansjörg, Kasper, Marco, Tedaldi, Laura S, Spruill, Miriam, Gullo, Martin E, Schwab, Thomas M, Kessler

Publikováno v: BJU international. 115

To develop a urodynamic model incorporating external urethral sphincter (EUS) electromyography (EMG) in awake rats.Bladder catheters and EUS EMG electrodes were implanted in female Sprague Dawley rats. Assessments were performed in awake, lightly res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d8993dedf9497d74a45ca23229284d89
https://pubmed.ncbi.nlm.nih.gov/25597776

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HelioScan : A software framework for controlling in vivo microscopy setups with high hardware flexibility, functional diversity and extendibility

Autor: Marcel van ’t Hoff, Chetan Nagaraja, Hansjörg Kasper, Maurice Göldi, Oliver A. Pfäffli, Andreas J Keller, Dominik Langer, Fritjof Helmchen

Publikováno v: Journal of Neuroscience Methods, 215 (1)
Journal of neuroscience methods

Intravital microscopy such as in vivo imaging of brain dynamics is often performed with custom-built microscope setups controlled by custom-written software to meet specific requirements. Continuous technological advancement in the field has created

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d7e4d80fa3b5bf64663d2bdde8054c
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-201813

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