Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Hansi Zhang"'
Publikováno v:
Journal of Dairy Science, Vol 107, Iss 4, Pp 1928-1949 (2024)
ABSTRACT: This study evaluated 75 strains of lactic acid bacteria (LAB) isolated from traditional dairy products in western China for their probiotic properties. Among them, Limosilactobacillus fermentum WXZ 2-1, Lactiplantibacillus plantarum TXZ 2-3
Externí odkaz:
https://doaj.org/article/7c8c17bd193348d69846e6492463efcd
High-throughput target trial emulation for Alzheimer’s disease drug repurposing with real-world data
Autor:
Chengxi Zang, Hao Zhang, Jie Xu, Hansi Zhang, Sajjad Fouladvand, Shreyas Havaldar, Feixiong Cheng, Kun Chen, Yong Chen, Benjamin S. Glicksberg, Jin Chen, Jiang Bian, Fei Wang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Target trial emulation is the process of mimicking target randomized trials using real-world data, where effective confounding control for unbiased treatment effect estimation remains a main challenge. Although various approaches have been p
Externí odkaz:
https://doaj.org/article/b2e1674323ba417c94bece81fe96e6ea
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Overly restrictive eligibility criteria for clinical trials may limit the generalizability of the trial results to their target real-world patient populations. We developed a novel machine learning approach using large collections of real-wo
Externí odkaz:
https://doaj.org/article/2a0ad89e542248798cd43931a93730a8
Autor:
Hansi Zhang, Liang Qiao, Xiaoxuan Liu, Xiaojing Han, Jing Kang, Yanli Liu, Juntang Lin, Xin Yan
Publikováno v:
FEBS Open Bio, Vol 12, Iss 10, Pp 1828-1838 (2022)
Adipose tissue is a major component for the regulation of energy homeostasis by storage and release of lipids. As a core element of RNA‐induced silencing complex, argonaute2 (Ago2) plays critical role in maintenance of systemic metabolic demand. He
Externí odkaz:
https://doaj.org/article/ee881831724d450dbb6f974e0076324c
Autor:
Zhaoyi Chen, Hansi Zhang, Yi Guo, Thomas J. George, Mattia Prosperi, William R. Hogan, Zhe He, Elizabeth A. Shenkman, Fei Wang, Jiang Bian
Publikováno v:
npj Digital Medicine, Vol 4, Iss 1, Pp 1-9 (2021)
Abstract In this study, we explored the feasibility of using real-world data (RWD) from a large clinical research network to simulate real-world clinical trials of Alzheimer’s disease (AD). The target trial (i.e., NCT00478205) is a Phase III double
Externí odkaz:
https://doaj.org/article/612dc9dac3b54a81922e281028b3e3fd
Publikováno v:
BMC Medical Informatics and Decision Making, Vol 20, Iss S4, Pp 1-22 (2020)
Abstract Background To reduce cancer mortality and improve cancer outcomes, it is critical to understand the various cancer risk factors (RFs) across different domains (e.g., genetic, environmental, and behavioral risk factors) and levels (e.g., indi
Externí odkaz:
https://doaj.org/article/e2fbe619d1224a5aaa6726b15f8521ae
Autor:
Xiaoyan Lv, Yali Zhao, Xuehan Yang, Hao Han, Yue Ge, Meishuang Zhang, Hansi Zhang, Ming Zhang, Li Chen
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Pancreatic β-cell dysfunction is a key link during the progression of type 2 diabetes (T2DM), and SIRT1 participates in the regulation of various physiological activities of islet β-cells. However, as a key link in signal transduction, it is not cl
Externí odkaz:
https://doaj.org/article/73da8db325a44fb4b57abd7bf8bad2fb
Publikováno v:
Machines, Vol 10, Iss 4, p 266 (2022)
To help people with impairment of lower extremity movement regain the ability to stand and walk, and to enhance limb function, this study proposes an anthropomorphic design of an electrically driven, lower-limb exoskeleton rehabilitation robot. The a
Externí odkaz:
https://doaj.org/article/579eea58bd0c475fa67045cd39dc7471
Autor:
Juan Antonio Lossio-Ventura, William Hogan, François Modave, Yi Guo, Zhe He, Xi Yang, Hansi Zhang, Jiang Bian
Publikováno v:
BMC Medical Informatics and Decision Making, Vol 18, Iss S2, Pp 115-127 (2018)
Abstract Background There is strong scientific evidence linking obesity and overweight to the risk of various cancers and to cancer survivorship. Nevertheless, the existing online information about the relationship between obesity and cancer is poorl
Externí odkaz:
https://doaj.org/article/cb49dd1f3e3b4a7ab5c223ac1609efe4
Autor:
Hansi Zhang, Yi Guo, Qian Li, Thomas J. George, Elizabeth Shenkman, François Modave, Jiang Bian
Publikováno v:
BMC Medical Informatics and Decision Making, Vol 18, Iss S2, Pp 129-147 (2018)
Abstract Background Cancer is the second leading cause of death in the United States, exceeded only by heart disease. Extant cancer survival analyses have primarily focused on individual-level factors due to limited data availability from a single da
Externí odkaz:
https://doaj.org/article/19466a0e94b04b2b90a43aa06457525e