Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Hansen Luan"'
Publikováno v:
Pharmaceutical Fronts, Vol 01, Iss 01, Pp e11-e21 (2019)
The purpose of this study was to develop a solid dispersion (SD) by miniaturized hot-melt extrusion (HME) for an insoluble molecule ZL006 which showed potency of increasing leukocytes. A preliminary formulation screening was conducted using solvent e
Externí odkaz:
https://doaj.org/article/1acfd5678df64a079ced5fedbea684e3
Publikováno v:
Molecules, Vol 24, Iss 1, p 7 (2018)
ZL-004, a promising small molecule that increases white blood cell counts, was developed for extended-release nanosuspensions to improve low solubility and compliance of patients. In vivo pharmacokinetic studies of nanosuspensions with different part
Externí odkaz:
https://doaj.org/article/0b7654ec8965441081c8bee2f25649d6
Publikováno v:
Journal of Pharmaceutical Sciences. 109:950-958
The objective of this work was to identify an enabling formulation for an insoluble compound ZL006 with potency of boosting leukocytes after chemotherapy. The low oral bioavailability (1%) of its conventional suspension was the hurdle for the preclin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::759dba9612f641ccf85399339b1cfc2d
https://doi.org/10.1016/j.xphs.2019.10.023
https://doi.org/10.1016/j.xphs.2019.10.023
Autor:
Chengyue Guo, Jiaxin Wang, Yanna Chen, Manyu Hu, Hao Wang, Zhuangzhi Zhu, Ying Xu, Junzhe Zhu, Hansen Luan
Publikováno v:
Journal of Drug Delivery Science and Technology. 50:313-320
Nanosuspension has been widely used to improve the bioavailability of poorly soluble drugs. ZL-004, a promising small molecular compound with the function of raising counts of white blood cells, was developed to nanosuspensions to solve the low solub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d3ea5ec6875975546cc9fece3e12c9b
https://doi.org/10.1016/j.jddst.2019.01.034
https://doi.org/10.1016/j.jddst.2019.01.034
Publikováno v:
Pharmaceutical Fronts, Vol 01, Iss 01, Pp e11-e21 (2019)
The purpose of this study was to develop a solid dispersion (SD) by miniaturized hot-melt extrusion (HME) for an insoluble molecule ZL006 which showed potency of increasing leukocytes. A preliminary formulation screening was conducted using solvent e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ad6c3ca8d18e0175bd192a0394c203
http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1693657
http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1693657
Autor:
Jiaxin Pi, Shuya Wang, Xing Gu, Zhidong Liu, Hansen Luan, Zhuangzhi Zhu, Bing Zhang, Hao Wang
Publikováno v:
Current Drug Delivery. 13:1358-1366
Background: Ursolic acid (UA), a natural pentacyclic triterpenoid, has been reported to possess a variety of pharmacological activities, but the poor oral bioavailability of UA owing to the poor aqueous solubility and membrane permeability limits the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::570006cf7ad2b7b48a72d40570e88bdc
https://doi.org/10.2174/1567201813666160307142757
https://doi.org/10.2174/1567201813666160307142757
Publikováno v:
Molecules
Molecules, Vol 24, Iss 1, p 7 (2018)
Volume 24
Issue 1
Molecules, Vol 24, Iss 1, p 7 (2018)
Volume 24
Issue 1
ZL-004, a promising small molecule that increases white blood cell counts, was developed for extended-release nanosuspensions to improve low solubility and compliance of patients. In vivo pharmacokinetic studies of nanosuspensions with different part
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9e5310791b391e96afa7b4e2a87fc98
http://europepmc.org/articles/PMC6337511
http://europepmc.org/articles/PMC6337511
Autor:
Chunmeng Sun, Guiliang Chen, Xi Liu, Hansen Luan, Jiasheng Tu, Huiyi Li, Baoming Ning, Hao Wang
Publikováno v:
Journal of Pharmaceutical Innovation. 10:302-312
In this study, a new parameter, volume under response surface (VURS), based on the multiple integrals response surface (MIRS) was applied to establish in vitro-in vivo correlations (IVIVC) refer to in vitro dissolution data and in vivo pharmacokineti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c92613585a125b867d42834aae33fb4
https://doi.org/10.1007/s12247-015-9227-4
https://doi.org/10.1007/s12247-015-9227-4
Autor:
Hansen Luan, Xiuli Wang, Wang Hao, Feng Zhao, Zheng Huang, Hongwei Wang, Lei Shi, Qingfeng Tu
Publikováno v:
International Journal of Nanomedicine
Lei Shi,1 Xiuli Wang,1 Feng Zhao,2 Hansen Luan,2 Qingfeng Tu,1 Zheng Huang,3 Hao Wang,2 Hongwei Wang1,41Shanghai Skin Disease Hospital, Shanghai, People's Republic of China; 2National Pharmaceutical Engineering Research Center, China State Institute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa95de2cda6cbb292394afe33f6d0ee6
http://europepmc.org/articles/PMC3728265
http://europepmc.org/articles/PMC3728265
Autor:
Huafei Luo, Shaoqiong Tian, Chenghao Zhang, Hansen Luan, Xiaohua Ye, Qingwei Liu, Hao Wang, Zhong Huang, CheeYen Lim, Chaoyun Shen, Zhiqiang Ku, Zhuangzhi Zhu
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 243
Recent large outbreaks of hand-foot-and-mouth disease (HFMD) have seriously affected the health of young children. Enterovirus 71 (EV71) is the main causative agent of HFMD. Herein, for the first time, rapidly dissolvable microneedles (MNs) loaded wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::066365916f06e66481bcd0323ada1ba8
https://pubmed.ncbi.nlm.nih.gov/27793685
https://pubmed.ncbi.nlm.nih.gov/27793685