Synthesis of a heparin-related GlcN–IdoA sulfation-site variable disaccharide library and analysis by Raman and ROA spectroscopy

Autor: Miller, Gavin J., Hansen, Steen U., Baráth, Marek, Johannessen, Christian, Blanch, Ewan W., Jayson, Gordon C., Gardiner, John M.

Publikováno v: In Carbohydrate Research 5 December 2014 400:44-53

Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5cc05222j

Autor: Jayson, Gordon C., Hansen, Steen U., Miller, Gavin J., Cole, Claire L., Rushton, Graham, Avizienyte, Egle, Gardiner, John M.

Publikováno v: Chemical Communications (Cambridge, England)

Multigram-scale synthesis of a sulfation-site programmed dodecasaccharide is described. CXCL8- and CXCL12-mediated in vitro and in vivo biology is shown to be regulated by a single sulfation site change.
The multigram-scale synthesis of a sulfat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::25b1ed5d2708a5f8950a8fc649fce805
http://europepmc.org/articles/PMC4608306

Efficient chemical synthesis of heparin-like octa-, deca- and dodecasaccharides and inhibition of FGF2- and VEGF165-mediated endothelial cell functions

Autor: Miller, Gavin J., Hansen, Steen U., Avizienyte, Egle, Rushton, Graham, Cole, Claire, Jayson, Gordon C., Gardiner, John M., Mcdonald, Egle

Publikováno v: Miller, G J, Hansen, S U, Avizienyte, E, Rushton, G, Cole, C, Jayson, G C, Gardiner, J M & Mcdonald, E 2013, ' Efficient chemical synthesis of heparin-like octa-, deca-and dodecasaccharides and inhibition of FGF2-and VEGF165-mediated endothelial cell functions ', Chemical Science, vol. 4, no. 8, pp. 3218-3222 . https://doi.org/10.1039/c3sc51217g

A concise chemical synthesis of a series of structurally-defined heparin-like oligosaccharides is described. This work provides an efficient entry to octa-, deca-, and dodecasaccharides, including the first synthesis of (GlcNS6S-IdoA2S)5 and (GlcNS6S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc653aab98c343f4658eaeb19de47156

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