Zobrazeno 1 - 10
of 1 313
pro vyhledávání: '"Hans-uwe Simon"'
Autor:
Christina Bürgler, Danielle Dutoit, Susanne Radonjic‐Hoesli, Kathrin Thormann, Mathias Lehmann, Shida Yousefi, Hans‐Uwe Simon, Dagmar Simon
Publikováno v:
JEADV Clinical Practice, Vol 3, Iss 2, Pp 478-486 (2024)
Abstract Background Atopic dermatitis (AD) is characterized by skin barrier dysfunction and immune dysregulation. Autophagy, which is important for the epidermal differentiation, is impaired in AD. The treatment with dupilumab, an interleukin (IL)‐
Externí odkaz:
https://doaj.org/article/6a435cace1b1481c9e2f281e6735c8c8
Evidence for a Role of the Long Non-Coding RNA ITGB2-AS1 in Eosinophil Differentiation and Functions
Autor:
Timothée Fettrelet, Aref Hosseini, Jacqueline Wyss, Joanna Boros-Majewska, Darko Stojkov, Shida Yousefi, Hans-Uwe Simon
Publikováno v:
Cells, Vol 13, Iss 23, p 1936 (2024)
Eosinophils, a type of granulocyte derived from myeloid precursors in the bone marrow, are distinguished by their cytoplasmic granules. They play crucial roles in immunoregulation, tissue homeostasis, and host defense, while also contributing to the
Externí odkaz:
https://doaj.org/article/92c3f533a0de4b0fa492fd58eb0febb9
Autor:
Lea Gigon, Philipp Müller, Beat Haenni, Ioan Iacovache, Maruša Barbo, Gordana Gosheva, Shida Yousefi, Alice Soragni, Christoph von Ballmoos, Benoît Zuber, Hans-Uwe Simon
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114084- (2024)
Summary: Eosinophils play a crucial role in host defense while also contributing to immunopathology through the release of inflammatory mediators. Characterized by distinctive cytoplasmic granules, eosinophils securely store and rapidly release vario
Externí odkaz:
https://doaj.org/article/d182e05a08354491ada376f038ee4c1c
Autor:
Aref Hosseini, Nina Germic, Nikita Markov, Darko Stojkov, Kevin Oberson, Shida Yousefi, Hans-Uwe Simon
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
IntroductionObesity is a metabolic condition that elevates the risk of all-cause mortality. Brown and beige adipose tissues, known for their thermogenic properties, offer potential therapeutic targets for combating obesity. Recent reports highlight t
Externí odkaz:
https://doaj.org/article/76bbf05ed60842cdb495ddaf1a7098e2
Autor:
Lea Gigon, Timothée Fettrelet, Marta Miholic, Kenneth R. McLeish, Shida Yousefi, Darko Stojkov, Hans-Uwe Simon
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Neutrophils are a specialized subset of white blood cells, which have the ability to store pre-formed mediators in their cytoplasmic granules. Neutrophils are well-known effector cells involved in host protection against pathogens through diverse mec
Externí odkaz:
https://doaj.org/article/9ab84e271e424d90b258713911cfccff
Autor:
Yihe Chen, Nikita Markov, Lea Gigon, Aref Hosseini, Shida Yousefi, Darko Stojkov, Hans-Uwe Simon
Publikováno v:
Cells, Vol 13, Iss 4, p 322 (2024)
Macrophages play a crucial role in the innate immune response, serving as key effector cells in the defense against pathogens. Although the role of the large-conductance voltage and calcium-activated potassium channel, also known as the KCa1.1 or BK
Externí odkaz:
https://doaj.org/article/8ba83f82ee23434fbf39fae61945088b
Autor:
Oleg Shuvalov, Yulia Kirdeeva, Alexandra Daks, Olga Fedorova, Sergey Parfenyev, Hans-Uwe Simon, Nickolai A. Barlev
Publikováno v:
Antioxidants, Vol 12, Iss 11, p 2012 (2023)
Cancer metabolic reprogramming is a complex process that provides malignant cells with selective advantages to grow and propagate in the hostile environment created by the immune surveillance of the human organism. This process underpins cancer proli
Externí odkaz:
https://doaj.org/article/03d1055ade09473483a8e003b0c47098
Autor:
Quentin Haas, Nikita Markov, Lukas Muerner, Viviana Rubino, Andrej Benjak, Monika Haubitz, Gabriela M. Baerlocher, Charlotte K. Y. Ng, Christian Münz, Carsten Riether, Adrian F. Ochsenbein, Hans-Uwe Simon, Stephan von Gunten
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
While inhibitory Siglec receptors are known to regulate myeloid cells, less is known about their expression and function in lymphocytes subsets. Here we identified Siglec-7 as a glyco-immune checkpoint expressed on non-exhausted effector memory CD8+
Externí odkaz:
https://doaj.org/article/ee365483dca647a5aef0a91df47591e6
Autor:
Shuang Peng, Darko Stojkov, Jian Gao, Kevin Oberson, Philipp Latzin, Carmen Casaulta, Shida Yousefi, Hans-Uwe Simon
Publikováno v:
PLoS Biology, Vol 20, Iss 9, p e3001794 (2022)
In contrast to molecular changes associated with increased inflammatory responses, little is known about intracellular counter-regulatory mechanisms that control signaling cascades associated with functional responses of neutrophils. Active RHO GTPas
Externí odkaz:
https://doaj.org/article/c1d2fec0092a4a2da3e099dcff06a06b
Publikováno v:
Allergology International, Vol 70, Iss 1, Pp 30-38 (2021)
Neutrophils and eosinophils are granulocytes which are characterized by the presence of granules in the cytoplasm. Granules provide a safe storage site for granule proteins that play important roles in the immune function of granulocytes. Upon granul
Externí odkaz:
https://doaj.org/article/dc30f761c2b442c49b2c2479e1fc6735