Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Hans-Wolfgang Klafki"'
Autor:
Hans-Wolfgang Klafki, Barbara Morgado, Oliver Wirths, Olaf Jahn, Chris Bauer, Hermann Esselmann, Johannes Schuchhardt, Jens Wiltfang
Publikováno v:
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-14 (2022)
Abstract Background A reduced amyloid-β (Aβ)42/40 peptide ratio in blood plasma represents a peripheral biomarker of the cerebral amyloid pathology observed in Alzheimer’s disease brains. The magnitude of the measurable effect in plasma is smalle
Externí odkaz:
https://doaj.org/article/8ae8035bbb0640a297283a15a40c607b
Autor:
Freyja Aichholzer, Hans-Wolfgang Klafki, Isabella Ogorek, Jonathan Vogelgsang, Jens Wiltfang, Norbert Scherbaum, Sascha Weggen, Oliver Wirths
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-13 (2021)
Abstract Background Alzheimer’s disease (AD) is a neurodegenerative disorder associated with extracellular amyloid-β peptide deposition and progressive neuron loss. Strong evidence supports that neuroinflammatory changes such as the activation of
Externí odkaz:
https://doaj.org/article/05f6d351f5384f2c95c03641b6682c2e
Autor:
Angelika Sabine Bader, Marius-Uwe Gnädig, Merle Fricke, Luca Büschgens, Lena Josefine Berger, Hans-Wolfgang Klafki, Thomas Meyer, Olaf Jahn, Sascha Weggen, Oliver Wirths
Publikováno v:
Life, Vol 13, Iss 4, p 1053 (2023)
Senile plaques consisting of amyloid-beta (Aβ) peptides are a major pathological hallmark of Alzheimer’s disease (AD). Aβ peptides are heterogeneous regarding the exact length of their amino- and carboxy-termini. Aβ1-40 and Aβ1-42 are often con
Externí odkaz:
https://doaj.org/article/68237a998a89417498e77aaeb7a0356f
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2155 (2023)
A variety of factors has been associated with healthy brain aging, and epidemiological studies suggest that physical activity and nutritional supplements such as caffeine may reduce the risk of developing dementia and, in particular, Alzheimer’s di
Externí odkaz:
https://doaj.org/article/5bd77603d32643df9477387e8ca3ab47
Autor:
Timo Jan Oberstein, Philipp Spitzer, Hans-Wolfgang Klafki, Philipp Linning, Florian Neff, Hans-Joachim Knölker, Piotr Lewczuk, Jens Wiltfang, Johannes Kornhuber, Juan Manuel Maler
Publikováno v:
Neurobiology of Disease, Vol 73, Iss , Pp 24-35 (2015)
The neuropathological hallmarks of Alzheimer's disease include extracellular neuritic plaques and neurofibrillary tangles. The neuritic plaques contain β-amyloid peptides (Aβ peptides) as the major proteinaceous constituent and are surrounded by ac
Externí odkaz:
https://doaj.org/article/716113bc60174697895a62fcb024bb73
Autor:
Philipp Spitzer, Heinke Schieb, Heike Kamrowski-Kruck, Markus Otto, Davide Chiasserini, Lucilla Parnetti, Sanna-Kaisa Herukka, Johannes Schuchhardt, Jens Wiltfang, Hans-Wolfgang Klafki
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2011 (2011)
Cerebrospinal fluid (CSF) samples from 33 patients with Alzheimer dementia (AD), 21 patients with mild cognitive impairment who converted to AD during followup (MCI-AD), 25 patients with stable mild cognitive impairment (MCI-stable), and 16 nondement
Externí odkaz:
https://doaj.org/article/53597de6e4204270a0de18a6c774c6cd
Autor:
Thomas Liepold, Hans-Wolfgang Klafki, Sathish Kumar, Jochen Walter, Oliver Wirths, Jens Wiltfang, Olaf Jahn
Publikováno v:
Journal of the American Society for Mass Spectrometry
Amyloid-β (Aβ) peptides, including post-translationally modified variants thereof, are believed to play a key role in the onset and progression of Alzheimer’s disease. Suggested modified Aβ species with potential disease relevance include Aβ pe
Autor:
Angelika Sabine Bader, Marius-Uwe Gnädig, Merle Fricke, Luca Büschgens, Lena Josefine Berger, Hans-Wolfgang Klafki, Thomas Meyer, Olaf Jahn, Sascha Weggen, Oliver Wirths
Publikováno v:
Life
Life; Volume 13; Issue 4; Pages: 1053
Life; Volume 13; Issue 4; Pages: 1053
Senile plaques consisting of amyloid-beta (Aβ) peptides are a major pathological hallmark of Alzheimer’s disease (AD). Aβ peptides are heterogeneous regarding the exact length of their amino- and carboxy-termini. Aβ1-40 and Aβ1-42 are often con
Autor:
Hans‐Wolfgang Klafki, Oliver Wirths, Brit Mollenhauer, Thomas Liepold, Petra Rieper, Hermann Esselmann, Jonathan Vogelgsang, Jens Wiltfang, Olaf Jahn
Publikováno v:
Journal of neurochemistry 160(5), 578-589 (2022). doi:10.1111/jnc.15571
Journal of Neurochemistry
Journal of Neurochemistry
Neurochemical biomarkers can support the diagnosis of Alzheimer’s disease and may facilitate clinical trials. In blood plasma, the ratio of the amyloid-β (Aβ) peptides Aβ−3– 40/Aβ1–42 can predict cerebral amyloid-β pathology with high ac
Autor:
Timo Jan Oberstein, Janine Utz, Philipp Spitzer, Hans Wolfgang Klafki, Jens Wiltfang, Piotr Lewczuk, Johannes Kornhuber, Juan Manuel Maler
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2021)
Astrocytes may not only be involved in the clearance of Amyloid beta peptides (Aβ) in Alzheimer's disease (AD), but appear to produce N-terminally truncated Aβ (Aβn−x) independently of BACE1, which generates the N-Terminus of Aβ starting with A