Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Hans-Ulrich Naegeli"'
Autor:
Maximilian Woisetschlaeger, Kurt Mueller, Roman Bauer, Lukas Oberer, Johannes Ottl, Nathalie Harrer, Jan-Marcus Seifert, Volker Uhl, Christian Guenat, Martin Hintersteiner, Manfred Auer, Christof Buehler, Serge Moss, Nicole-Claudia Meisner, Hans-Ulrich Naegeli
Publikováno v:
Nature Chemical Biology. 3:508-515
Careful regulation of mRNA half-lives is a fundamental mechanism allowing cells to quickly respond to changing environmental conditions. The mRNA-binding Hu proteins are important for stabilization of short-lived mRNAs. Here we describe the identific
Autor:
Sven Schuierer, Lukas Oberer, Ralph Riedl, Jianshi Tao, Silvio Roggo, John S. Gounarides, Charlotte Miault, Stephen B. Helliwell, Marc Bergdoll, Juan Zhang, Klaus Memmert, Anais Margerit, Dominic Hoepfner, Pierre-Eloi Imbert, Christian N. Parker, Shantanu Karkare, Andreas Hofmann, Stefan Reinker, Hans-Ulrich Naegeli, Mathias Frederiksen, Alban Muller, Hong Yin, Ireos Filipuzzi, Trixie Wagner, Juliet R. Leighton-Davis, Alain Rahier, Philipp Krastel, Vivian Prindle, Celine Fioretto, Richard Knochenmuss, Thomas Aust, N. Rao Movva, Jessica A. Sexton, Rolf Jeker
Publikováno v:
Nature Communications
FR171456 is a natural product with cholesterol-lowering properties in animal models, but its molecular target is unknown, which hinders further drug development. Here we show that FR171456 specifically targets the sterol-4-alpha-carboxylate-3-dehydro
Autor:
Lukas Oberer, Philipp Krastel, Hans Ulrich Naegeli, Rowan P. Morris, Stacey Esterow, Esther K. Schmitt, Jennifer A. Leeds, Nathalie Burrer, Klaus Memmert, Matthew J. LaMarche, Andreas Hein, Christian N. Parker, Eric Weber
Publikováno v:
Journal of the American Chemical Society. 131(16)
We identified the thiomuracins, a novel family of thiopeptides produced by a rare-actinomycete bacterium typed as a Nonomuraea species, via a screen for inhibition of growth of the bacterial pathogen Staphylococcus aureus. Thiopeptides are a class of
Autor:
Elizabeth A. Tanner, Hans Ulrich Naegeli, Steven J. Freedman, Susan Cornell-Kennon, David M. Livingston, Annelisa Vieira, Klaus Memmert, Kenneth W. Bair, Frank Petersen, Sonya Zabludoff, Beqing Wang, Andrew L. Kung, Michael J. Eck, Jennifer Lee, Alexander W. Wood, Jamin Wang
Publikováno v:
Cancer cell. 6(1)
Homeostasis under hypoxic conditions is maintained through a coordinated transcriptional response mediated by the hypoxia-inducible factor (HIF) pathway and requires coactivation by the CBP and p300 transcriptional coactivators. Through a target-base
Autor:
Ulrich Hommel, Carolyn A. Foster, Hans-Peter Weber, Berndt Oberhauser, Lukas Oberer, Hans Ulrich Naegeli
Publikováno v:
FEBS letters. 379(1)
The three-dimensional structure of cyclopeptolide HUN-7293, a naturally-occurring inhibitor of cell adhesion molecule expression, has been determined from nuclear magnetic resonance data recorded in solution and from X-ray diffraction analysis of sin
Autor:
Hans Ulrich Naegeli, Brigitte Mandak, Michael Dreyfuss, Carolyn A. Foster, Alexius Nussbaumer, Eva-Maria Swoboda, Josef G. Meingassner, Günther Scheel, Lukas Oberer
Publikováno v:
The Journal of dermatology. 21(11)
Skin diseases with an inflammatory component, regardless of their etiology, are characterized at some point by the extravasation and subsequent infiltration of leukocytes into the dermal and/or epidermal compartments. This trafficking pattern is dete
Autor:
Hans-Ulrich Naegeli, Hans Zähner
Publikováno v:
Helvetica Chimica Acta. 63:1400-1406
Metabolites of Microorganisms. Ferrithiocin The strain Tu 1998 from Streptomyces antibioticus produces besides the indicator antibiotics β- and γ-rubromycins a new sulfur containing metabolite. This metabolite, called ferrithiocin, has been isolate
Publikováno v:
Helvetica Chimica Acta. 61:2088-2095
Metabolites of Microorganisms. A New Synthesis of Ferrichrome; enantio-Ferrichrome The enantiomer of the natural sideramine ferrichrome was synthesized starting from D-ornithine. The cyclohexapeptide (D-Orn)3-Gly3 was obtained by conventional methods
Publikováno v:
European journal of biochemistry. 99(1)
Uptake of ferric iron from ferricrocin was studied in Escherichia coli using a polymer-coupled ferricrocin that was unable to penetrate into the cell. Ferricrocinyl polyethylene glycol succinate (Mr 7000 -- 8500) promoted growth of E. coli K-12 AB284
Publikováno v:
The Journal of antibiotics. 39(4)
Clavamycins A, B, C, D, E and F represent new members of the clavam antibiotics group. Their purification was achieved by a variety of preparative chromatographic methods, essentially on reversed phase carrier. The structures were deduced from spectr