Výsledky vyhledávání - "Hans-Peter Steffens"

The Putative Natural Killer Decoy Early Genem04(gp34) of Murine Cytomegalovirus Encodes an Antigenic Peptide Recognized by Protective Antiviral CD8 T Cells

Autor: Matthias J. Reddehase, Doris Thomas, Jürgen Podlech, Hans-Peter Steffens, Rafaela Holtappels, Gernot Geginat

Publikováno v: Journal of Virology. 74:1871-1884

Several early genes of murine cytomegalovirus (MCMV) encode proteins that mediate immune evasion by interference with the major histocompatibility complex class I (MHC-I) pathway of antigen presentation to cytolytic T lymphocytes (CTL). Specifically,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0423565fae4a3ff8ee1f63ddfe6f0d9a
https://doi.org/10.1128/jvi.74.4.1871-1884.2000

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In Vivo Replication of Recombinant Murine Cytomegalovirus Driven by the Paralogous Major Immediate-Early Promoter-Enhancer of Human Cytomegalovirus

Autor: Rafaela Holtappels, Matthias J. Reddehase, Jürgen Podlech, Susanne Schmalz, Hans-Peter Steffens, Natascha K. A. Grzimek

Publikováno v: Journal of Virology. 73:5043-5055

Transcription of the major immediate-early (MIE) genes of cytomegaloviruses (CMV) is driven by a strong promoter-enhancer (MIEPE) complex. Transactivator proteins encoded by these MIE genes are essential for productive infection. Accordingly, the MIE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dcb35174724594c02d0045bec74229e
https://doi.org/10.1128/jvi.73.6.5043-5055.1999

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Preemptive CD8 T-Cell Immunotherapy of Acute Cytomegalovirus Infection Prevents Lethal Disease, Limits the Burden of Latent Viral Genomes, and Reduces the Risk of Virus Recurrence

Autor: Matthias J. Reddehase, Rafaela Holtappels, Sabine Kurz, Hans-Peter Steffens

Publikováno v: Journal of Virology. 72:1797-1804

In the immunocompetent host, primary cytomegalovirus (CMV) infection is resolved by the immune response without causing overt disease. The viral genome, however, is not cleared but is maintained in a latent state that entails a risk of virus recurren

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b6435e27e1531a174b0295aa24db6e
https://doi.org/10.1128/jvi.72.3.1797-1804.1998

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Focal Transcriptional Activity of Murine Cytomegalovirus during Latency in the Lungs

Autor: Maria Rapp, Hans-Peter Steffens, Sabine Kurz, Natascha K. A. Grzimek, Matthias J. Reddehase, Susanne Schmalz

Interstitial pneumonia is a frequent and critical manifestation of human cytomegalovirus (CMV) disease in immunocompromised patients, in particular in recipients of bone marrow transplantation. Previous work in the murine CMV infection model has iden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63624d620ab9b1b8c807e55fabc4ddb2
https://europepmc.org/articles/PMC103855/

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Bone marrow failure by cytomegalovirus is associated with an in vivo deficiency in the expression of essential stromal hemopoietin genes

Autor: Jürgen Podlech, Liane Dreher, Peter Angele, S Maiberger, Sabine Kurz, Hans-Peter Steffens, A Mayer, K Thalmeier, Matthias J. Reddehase

Publikováno v: Scopus-Elsevier

Bone marrow (BM) failure associated with cytomegalovirus (CMV) infection is a feared complication after clinical BM transplantation. Experiments in long-term BM cultures have indicated that BM stromal cells (BMSC) are targets of productive CMV infect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::638313075ac7d73040ec5897f2900d2f
https://europepmc.org/articles/PMC191681/

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Interferon-alpha (IFN-alpha) inhibits granulocyte-macrophage colony-stimulating factor (GM-CSF) expression at the post-transcriptional level in murine bone marrow stromal cells

Autor: M. Javad Aman, Hans Peter Steffens, Christoph Huber, Gerhard Goullner, H. Guunter Derigs, C. Peschel

Publikováno v: British journal of haematology. 91(1)

Recently it has been shown that IFN-alpha inhibits expression of GM-CSF in adherent cells of human long-term bone marrow cultures (LTBMC) stimulated with interleukin-1 (IL-1), tumour necrosis factor-alpha (TNF-alpha) or endotoxin. The murine bone mar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd90196621fa763e13ab8faaddb2022
https://pubmed.ncbi.nlm.nih.gov/7577656

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Control of cytomegalovirus in bone marrow transplantation chimeras lacking the prevailing antigen-presenting molecule in recipient tissues rests primarily on recipient-derived CD8 T cells

Autor: Jürgen Podlech, Mariagabriela Alterio de Goss, Hans-Peter Steffens, Peter Angele, Liane Dreher, Doris Thomas, Rafaela Holtappels, Matthias J. Reddehase

Publikováno v: Scopus-Elsevier

Cytomegalovirus (CMV) infection during the transient immunodeficiency after bone marrow transplantation (BMT) develops into disease unless antiviral CD8 T cells are restored in due course. Histoincompatibility between donor and recipient is associate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d7e0183467f90a14badd99ca3ccd738
http://www.scopus.com/inward/record.url?eid=2-s2.0-3543144320&partnerID=MN8TOARS

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Cytomegalovirus inhibits the engraftment of donor bone marrow cells by downregulation of hemopoietin gene expression in recipient stroma

Autor: Doris Dreis, Hans-Peter Steffens, Matthias J. Reddehase, Jürgen Podlech, Sabine Kurz, Peter Angele

Publikováno v: Scopus-Elsevier

Cytomegalovirus (CMV) disease after bone marrow (BM) transplantation is often associated with BM graft failure. There are two possible reasons for such a correlation. First, a poor hematopoietic reconstitution of unrelated etiology could promote the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06773470631f8ba0456061d2d50cac38
http://www.scopus.com/inward/record.url?eid=2-s2.0-0031924470&partnerID=MN8TOARS

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Latency versus persistence or intermittent recurrences: Evidence for a latent state of murine cytomegalovirus in the lungs

Autor: J R Harris, Hans-Peter Steffens, A Mayer, Matthias J. Reddehase, Sabine Kurz

Publikováno v: Scopus-Elsevier

The state of cytomegalovirus (CMV) after the resolution of acute infection is an unsolved problem in CMV research. While the term "latency" is in general use to indicate the maintenance of the viral genome, a formal exclusion of low-level persistent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92c6bd8b1d47c757dd7d26a005ffb1fa
http://www.scopus.com/inward/record.url?eid=2-s2.0-0030945467&partnerID=MN8TOARS

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Control of murine cytomegalovirus in the lungs: Relative but not absolute immunodominance of the immediate-early 1 nonapeptide during the antiviral cytolytic T-lymphocyte response in pulmonary infiltrates

Autor: Hans-Peter Steffens, Matthias J. Reddehase, Doris Thomas, Gernot Geginat, Rafaela Holtappels, Jürgen Podlech

Publikováno v: Scopus-Elsevier

Effective control by the immune system is a hallmark of cytomegalovirus (CMV) infection. Accordingly, human CMV disease is a medical problem restricted to the immunologically immature or immunocompromised host (for a review, see reference 21). Murine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1129f09c5dda4d377cb2f186a7e5aee
http://www.scopus.com/inward/record.url?eid=2-s2.0-0031870165&partnerID=MN8TOARS

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