Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Hans-Joachim Knolker"'
Autor:
Daniel Auguin, Julien Robert-Paganin, Stéphane Réty, Carlos Kikuti, Amandine David, Gabriele Theumer, Arndt W. Schmidt, Hans-Joachim Knölker, Anne Houdusse
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Inherited cardiomyopathies are common cardiac diseases worldwide, leading in the late stage to heart failure and death. The most promising treatments against these diseases are small molecules directly modulating the force produced by β-car
Externí odkaz:
https://doaj.org/article/363d3a02b7d54aa8bbcb3c56b4a01f3f
Autor:
Dumaa Mishig, Margit Gruner, Tilo Lübken, Chunsriimyatav Ganbaatar, Duger Regdel, Hans-Joachim Knölker
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract The seven pyridine alkaloids 1–7, the flavonoid acacetin (8), and L-proline anhydride (9) have been isolated from the aerial parts of the Mongolian medicinal plant Caryopteris mongolica Bunge. The structures of the natural products 1–9 h
Externí odkaz:
https://doaj.org/article/9d218fb6802c492487e8bb9f538020ac
Autor:
Alice Åslund, Muhammad Hamza Bokhari, Erika Wetterdal, René Martin, Hans-Joachim Knölker, Tore Bengtsson
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101247- (2021)
Objective: The potential of brown adipose tissue (BAT) to influence energy homeostasis in animals and humans is encouraging as this tissue can increase fatty acid and glucose utilization to produce heat through uncoupling protein 1 (UCP1), but the ac
Externí odkaz:
https://doaj.org/article/ae374df47e294f249f62bd9fdbd09903
Loss of Motor Protein MYO1C Causes Rhodopsin Mislocalization and Results in Impaired Visual Function
Autor:
Ashish K. Solanki, Manas R. Biswal, Stephen Walterhouse, René Martin, Altaf A. Kondkar, Hans-Joachim Knölker, Bushra Rahman, Ehtesham Arif, Shahid Husain, Sandra R. Montezuma, Deepak Nihalani, Glenn Prazere Lobo
Publikováno v:
Cells, Vol 10, Iss 6, p 1322 (2021)
Unconventional myosins, linked to deafness, are also proposed to play a role in retinal cell physiology. However, their direct role in photoreceptor function remains unclear. We demonstrate that systemic loss of the unconventional myosin MYO1C in mic
Externí odkaz:
https://doaj.org/article/d46286f3dcd945bd8a10a6942a11b691
Autor:
Timo Jan Oberstein, Philipp Spitzer, Hans-Wolfgang Klafki, Philipp Linning, Florian Neff, Hans-Joachim Knölker, Piotr Lewczuk, Jens Wiltfang, Johannes Kornhuber, Juan Manuel Maler
Publikováno v:
Neurobiology of Disease, Vol 73, Iss , Pp 24-35 (2015)
The neuropathological hallmarks of Alzheimer's disease include extracellular neuritic plaques and neurofibrillary tangles. The neuritic plaques contain β-amyloid peptides (Aβ peptides) as the major proteinaceous constituent and are surrounded by ac
Externí odkaz:
https://doaj.org/article/716113bc60174697895a62fcb024bb73
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180301 (2017)
Myosin-1 (Myo1) represents a mechanical link between the membrane and actin-cytoskeleton in animal cells. We have studied the effect of Myo1 inhibitor PClP in 1-8 cell Zebrafish embryos. Our results indicate a unique involvement of Myo1 in early deve
Externí odkaz:
https://doaj.org/article/06b5df994f2d4e32af088fe93b39cd63
Autor:
Prabuddha Gupta, Nils C. Gauthier, Yu Cheng-Han, Yuan Zuanning, Bruno Pontes, Malte Ohmstede, René Martin, Hans-Joachim Knölker, Hans-Günther Döbereiner, Mira Krendel, Michael Sheetz
Publikováno v:
Biology Open, Vol 2, Iss 12, Pp 1288-1299 (2013)
Summary Because the actin network in active lamellipodia is continuously assembling at the edge, moving inward and disassembling, there is a question as to how actin-binding proteins and other components are transported to the leading edge and how na
Externí odkaz:
https://doaj.org/article/c4553e7e02cf4a579b58abc3b35031f5
Autor:
Anna Meljon, Spyridon Theofilopoulos, Cedric H.L. Shackleton, Gordon L. Watson, Norman B. Javitt, Hans-Joachim Knölker, Ratni Saini, Ernest Arenas, Yuqin Wang, William J. Griffiths
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 11, Pp 2469-2483 (2012)
Unesterified cholesterol is a major component of plasma membranes. In the brain of the adult, it is mostly found in myelin sheaths, where it plays a major architectural role. In the newborn mouse, little myelination of neurons has occurred, and much
Externí odkaz:
https://doaj.org/article/a741b3827125454fb17d6fdba5a7cf6b
Autor:
Ulrike Schmidt, Gabriele Theumer, Anne Jäger, Olga Kataeva, Baojie Wan, Scott G. Franzblau, Hans-Joachim Knölker
Publikováno v:
Molecules, Vol 23, Iss 6, p 1402 (2018)
The tetracyclic pyrido[4,3-b]carbazole olivacine and four of its oxygenated derivatives have been synthesized by a late-stage palladium-catalyzed Heck-type cyclization of the pyrrole ring as a key step. In a test for the inhibition of the growth of M
Externí odkaz:
https://doaj.org/article/42d4ce2a6bfc4c5ba14ab5dcb21bb387
Autor:
Vitali Matyash, Eugeni V Entchev, Fanny Mende, Michaela Wilsch-Bräuninger, Christoph Thiele, Arndt W Schmidt, Hans-Joachim Knölker, Samuel Ward, Teymuras V Kurzchalia
Publikováno v:
PLoS Biology, Vol 2, Iss 10, p e280 (2004)
Upon starvation or overcrowding, Caenorhabditis elegans interrupts its reproductive cycle and forms a specialised larva called dauer (enduring). This process is regulated by TGF-beta and insulin-signalling pathways and is connected with the control o
Externí odkaz:
https://doaj.org/article/3de4dd8da18f45f7a66c52e35c1f5196