Zobrazeno 1 - 10 of 65 pro vyhledávání: '"Hans-Joachim Böhm"'
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Akademický článek
What helps, what hinders?—Focus group findings on barriers and facilitators for mobile service robot use in a psychosocial group therapy for people with dementia
Autor: Catharina Wasic, Robert Erzgräber, Manja Unger-Büttner, Carolin Donath, Hans-Joachim Böhme, Elmar Graessel
Publikováno v: Frontiers in Robotics and AI, Vol 11 (2024)
IntroductionMany countries are facing a shortage of healthcare workers. Furthermore, healthcare workers are experiencing many stressors, resulting in psychological issues, impaired health, and increased intentions to leave the workplace. In recent ye
Externí odkaz: https://doaj.org/article/f554185c7b744bd38bf38e4f1350e8e7
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Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors
Autor: Thierry Lavé, Hans-Joachim Böhm, Ulrike Obst-Sander, David Banner, Lutz Weber, Martin Stahl, Markus A. Riederer, Kurt Hilpert, Hans Peter Wessel, Thomas B. Tschopp, Katrin Groebke Zbinden, Holger Kühne, Leo Alig, Jean Ackermann
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 15:5344-5352
We describe the structure-based design and synthesis of highly potent, orally bioavailable tissue factor/factor VIIa inhibitors which interfere with the coagulation cascade by selective inhibition of the extrinsic pathway.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6032880aca0a8668a787f6fa99dc00cb
https://doi.org/10.1016/j.bmcl.2005.04.079
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Second-Generation Inhibitors for the Metalloprotease Neprilysin Based on Bicyclic Heteroaromatic Scaffolds: Synthesis, Biological Activity, and X-Ray Crystal-Structure Analysis
Autor: Christian Oefner, Johannes Aebi, Glenn E. Dale, Stefan Sahli, François Diederich, Hans-Joachim Böhm, W. Bernd Schweizer, Brian Frank, Denise Blum-Kaelin
Publikováno v: Helvetica Chimica Acta. 88:731-750
A new class of nonpeptidic inhibitors of the ZnII-dependent metalloprotease neprilysin with IC50 values in the nanomolar activity range (0.034–0.30 μM) were developed based on structure-based de novo design (Figs. 1 and 2). The inhibitors feature
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6dcef800a1157dff7200eafccb7809a0
https://doi.org/10.1002/hlca.200590051
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A New Class of Inhibitors for the Metalloprotease Neprilysin Based on a Central Imidazole Scaffold
Autor: Hans-Joachim Böhm, Johannes Aebi, Tobias Welti, Bernhard Stump, Denise Blum-Kaelin, W. Bernd Schweizer, François Diederich, Stefan Sahli
Publikováno v: Helvetica Chimica Acta. 88:707-730
Neprilysin (NEP; neutral endopeptidase EC 3.4.24.11) is a Zn-II-dependent, membrane-bound endopeptidase. NEP is widely distributed in the organs, particularly in the kidneys and lungs, and it is involved in the metabolism of a number of smaller regul
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::31eb9ca7dde05813a171953dfc27a695
https://doi.org/10.1002/hlca.200590050
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6
Fluorine in Medicinal Chemistry
Autor: Hans-Joachim Böhm, Ulrike Obst-Sander, Stefanie Bendels, Martin Stahl, David Banner, Manfred Kansy, Klaus Müller, Bernd Kuhn
Publikováno v: ChemBioChem. 5:637-643
Fluorinated compounds are synthesized in pharmaceutical research on a routine basis and many marketed compounds contain fluorine. The present review summarizes some of the most frequently employed strategies for using fluorine substituents in medicin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f57158a624de83b526612f9bd6f42a42
https://doi.org/10.1002/cbic.200301023
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7
Docking and Scoring Functions/Virtual Screening
Autor: Martin Stahl, Christoph A. Sotriffer, Hans-Joachim Böhm, Gerhard Klebe
Publikováno v: Burger's Medicinal Chemistry and Drug Discovery
Docking is a computational procedure to investigate the binding between potential ligands and a macromolecular target whose 3D structure is known. Accordingly, it plays an essential role in structure-based drug design. Any automated docking program r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b11c93c390be4d8bbcd910d648cc5107
https://doi.org/10.1002/0471266949.bmc007
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8
Scaffold hopping
Autor: Hans-Joachim Böhm, Alexander Flohr, Martin Stahl
Publikováno v: Drug discovery today. Technologies. 1(3)
The aim of scaffold hopping is to discover structurally novel compounds starting from known active compounds by modifying the central core structure of the molecule. Scaffold hopping is a central task of modern medicinal chemistry requiring a multitu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d12bc0252ec33ba2ae18d9e51bbfdf
https://pubmed.ncbi.nlm.nih.gov/24981488
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