Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Hans-Jürgen Schulten"'
Autor:
Paul Thelen, Hans Jürgen Schulten, Bastian Gunawan, Holger Nagel, Christoph Borst, Andreas Polten, Christina Perske
Publikováno v:
Cancer Genetics and Cytogenetics. 176:35-47
We describe two newly established malignant mesothelioma (MM) cell lines derived from a pleural effusion of a male. One cell line, designated as MM-Z03E, reveals an epithelioid cobblestone morphology, while the second one, designated as MM-Z03S and s
Autor:
László Füzesi, Karthinathan Thangavelu, Hans-Jürgen Schulten, Norbert Graf, Ivo Leuschner, Rolf-Hermann Ringert, Bastian Gunawan, Thorsten Schlomm, Björn Sander
Publikováno v:
Clinical Cancer Research. 11:4382-4387
The management of Wilms' tumors consists of a combination of surgery, chemotherapy, and possibly radiotherapy. To date, chemotherapy is being risk stratified according to histologic subtype and stage. Although the cytogenetic characteristics of Wilms
Autor:
Bastian Gunawan, Jens Kuhlgatz, Christina Enders, Claus Langer, Christian G. Schindler, Hans-Jürgen Schulten, J. Höer, Bettina Schmidt, P. Schüler, Anja von Heydebreck, László Füzesi
Publikováno v:
The Journal of Pathology. 202:421-429
Although the significance of tumour site for estimating malignant potential in gastrointestinal stromal tumours (GISTs) has recently been recognized, site-specific genetic patterns have not to date been defined. This study examined 52 c-kit-positive
Publikováno v:
Virchows Archiv. 439:85-89
To fully characterize the numerous chromosomal aberrations in two human squamous cell carcinomas (SCCs) of the lung, molecular cytogenetic characterization was carried out utilizing conventional banding analysis and multicolor fluorescence in situ hy
Publikováno v:
Journal of Cellular Biochemistry. 83:155-162
The testis-specific proacrosin gene encodes for a fertilization-promoting protein. In mouse and rat it is first transcribed in late pachytene spermatocytes and revealed to be translationally regulated. Former proacrosin promoter studies demonstrated
Autor:
Bastian Gunawan, Gerhard Burckhardt, Glen Reid, Natascha A. Wolff, Andrew Bahn, Annette Hillemann, Hans-Jürgen Schulten, Bernhard Zabel, Diana Buttler, Dirk Prawitt, Christian Ebbinghaus, Thorsten Enklaar, Lazlo Füzesi
Publikováno v:
Biochemical and Biophysical Research Communications. 275:623-630
The human organic anion transporter 1 (hOAT1) plays a key role in the secretion of an array of potentially toxic organic anions including many clinically important drugs. Here we report on the genomic cloning of hOAT1. A human genomic library was use
Autor:
Bastian Gunawan, Florian Haller, Thomas Armbrust, Claus Langer, Detlef Doenecke, László Füzesi, S. Schwager, Hans-Jürgen Schulten, Anja von Heydebreck, Nicole Happel
Publikováno v:
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 20(10)
In gastrointestinal stromal tumors (GISTs), mutually exclusive gain-of-function mutations of KIT and PDGFRA are associated with different mutation-dependent clinical behavior. Taking into account the well-known different clinical behavior of GISTs fr
Autor:
László Füzesi, Hans-Jürgen Schulten, Gernot Jundt, Martin Oberholzer, Daniel Baumhoer, Christoph Kettelhack, Paula Hasenboehler, Kathrin Glatz, R. Fricker
Publikováno v:
Virchows Archiv : an international journal of pathology. 451(5)
Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare low-grade sarcoma of the distal extremities characterized by a myxohyaline stroma, a dense inflammatory infiltrate and virocyte- and lipoblast-like giant cells. Up to now, only two cases have bee
Autor:
Bastian Gunawan, Florian Haller, Claus Langer, Hans-Jürgen Schulten, László Füzesi, Thomas Armbrust
Publikováno v:
The American journal of surgical pathology. 31(6)
Most sporadic gastrointestinal stromal tumors (GISTs) occur solitary, whereas a multicentric appearance is suspicious for a familial or syndromal setting such as with germline mutations of proto-oncogene tyrosine protein kinase Kit (KIT) or platelet
Autor:
Sven Detken, Hans-Jürgen Schulten, Jens Kuhlgatz, Florian Haller, László Füzesi, Bastian Gunawan, Nicole Happel
Publikováno v:
Annals of surgical oncology. 14(2)
In metastasized GISTs, resistance to imatinib after initial tumour response has been associated with observation of secondary mutations in the activation loop of KIT. The aim of the current study was to evaluate the tumour response and observance of