Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Hans-Henning Ludwig"'
Autor:
Hans-Henning Ludwig, Matthias Stoldt, Hans-Ulrich Demuth, Martin Kleinschmidt, Justin Lecher, Dieter Willbold, Susanne Aileen Funke, Rudolf Hartmann, Na Sun, Lothar Gremer
Publikováno v:
Journal of Peptide Science. 18:691-695
The aggregation of the Aβ plays a fundamental role in the pathology of AD. Recently, N-terminally modified Aβ species, pE-Aβ, have been described as major constituents of Aβ deposits in the brains of AD patients. pE-Aβ has an increased aggregati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70399ccbfd9e1d593ab92a1738e32b35
https://doi.org/10.1002/psc.2456
https://doi.org/10.1002/psc.2456
Autor:
Stephan Schilling, Gerd Hause, Hans-Henning Ludwig, Hans-Ulrich Demuth, Holger Cynis, Dagmar Schlenzig, Eike Scheel, Raik Rönicke, Takaomi C. Saido, Klaus G. Reymann
Publikováno v:
Journal of Neurochemistry. 121:774-784
J. Neurochem. (2012) 121, 774–784. Abstract Pyroglutamate (pGlu)-modified amyloid peptides have been identified in sporadic and familial forms of Alzheimer’s disease (AD) and the inherited disorders familial British and Danish Dementia (FBD and F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc4ee721f5b6713c21b5aa505dfa2576
https://doi.org/10.1111/j.1471-4159.2012.07707.x
https://doi.org/10.1111/j.1471-4159.2012.07707.x
Autor:
Milton T. Stubbs, Christoph Parthier, Birgit Koch, Stephan Schilling, David Ruiz-Carrillo, Mirko Buchholz, Jens-Ulrich Rahfeld, Hans-Henning Ludwig, Michael Wermann, Hans-Ulrich Demuth, Tresfore Dambe, Ulrich Heiser
Publikováno v:
Biochemistry. 50:6280-6288
Formation of N-terminal pyroglutamate (pGlu or pE) from glutaminyl or glutamyl precursors is catalyzed by glutaminyl cyclases (QC). As the formation of pGlu-amyloid has been linked with Alzheimer's disease, inhibitors of QCs are currently the subject
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe0cdd61be71835aac71892d17a91bff
https://doi.org/10.1021/bi200249h
https://doi.org/10.1021/bi200249h
Autor:
Stephan von Hörsten, Arne Börgel, Åsa Petersén, Sofia Hult Lundh, Maria Björkqvist, Hans-Henning Ludwig, Raik Wolf, Hans-Ulrich Demuth, Blair R. Leavitt, Leona Wagner, Dagmar Schlenzig, Jens-Ulrich Rahfeld
Publikováno v:
Journal of neurochemistry. 137(5)
Huntington's disease (HD) is an inherited and fatal polyglutamine neurodegenerative disorder caused by an expansion of the CAG triplet repeat coding region within the HD gene. Progressive dysfunction and loss of striatal GABAergic medium spiny neuron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9bca5816a09bf76caf02c19239924c9
https://pubmed.ncbi.nlm.nih.gov/27016395
https://pubmed.ncbi.nlm.nih.gov/27016395
Autor:
Stephan Schilling, Teresa Weichler, Kai Tittmann, Franziska Seifert, Hans-Henning Ludwig, Hans-Ulrich Demuth
Phosphate ions and glutaminyl cyclase (QC) both catalyze the formation of pyroglutamate (pE, pGlu) from N-terminal glutamine residues of peptides and proteins. Here, we studied the mechanism of glutamine cyclization using kinetic secondary deuterium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c16f7646f1fa3143f0fe66aee932cc15
https://publica.fraunhofer.de/handle/publica/242774
https://publica.fraunhofer.de/handle/publica/242774
Autor:
Stephan Schilling, Bert H.-O. Güttler, Hans-Henning Ludwig, Holger Cynis, Franziska Seifert, Andrea Porzel
Publikováno v:
Amino acids. 44(4)
The formation of isoaspartate (isoAsp) from asparaginyl or aspartyl residues is a spontaneous post-translational modification of peptides and proteins. Due to isopeptide bond formation, the structure and possibly function of peptides and proteins is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f160fc81749024f6e2c44125079156
https://pubmed.ncbi.nlm.nih.gov/23344882
https://pubmed.ncbi.nlm.nih.gov/23344882
Autor:
Na, Sun, Rudolf, Hartmann, Justin, Lecher, Matthias, Stoldt, Susanne Aileen, Funke, Lothar, Gremer, Hans-Henning, Ludwig, Hans-Ulrich, Demuth, Martin, Kleinschmidt, Dieter, Willbold
Publikováno v:
Journal of peptide science : an official publication of the European Peptide Society. 18(11)
The aggregation of the Aβ plays a fundamental role in the pathology of AD. Recently, N-terminally modified Aβ species, pE-Aβ, have been described as major constituents of Aβ deposits in the brains of AD patients. pE-Aβ has an increased aggregati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fa21df3dfdbd1b5157d6b08df84c8159
https://pubmed.ncbi.nlm.nih.gov/23001756
https://pubmed.ncbi.nlm.nih.gov/23001756
Autor:
Dagmar, Schlenzig, Raik, Rönicke, Holger, Cynis, Hans-Henning, Ludwig, Eike, Scheel, Klaus, Reymann, Takaomi, Saido, Gerd, Hause, Stephan, Schilling, Hans-Ulrich, Demuth
Publikováno v:
Journal of neurochemistry 121(5), 774-784 (2012). doi:10.1111/j.1471-4159.2012.07707.x
Pyroglutamate (pGlu)-modified amyloid peptides have been identified in sporadic and familial forms of Alzheimer's disease (AD) and the inherited disorders familial British and Danish Dementia (FBD and FDD). In this study, we characterized the aggrega
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e4cd2f2585ddf51e56d75903be9ff1a5
https://pub.dzne.de/record/136501
https://pub.dzne.de/record/136501
Autor:
Fred Rosche, Susanne Manhart, Livia Böhme, Torsten Hoffmann, Hans-Henning Ludwig, Hans-Ulrich Demuth, Joachim Bär
Publikováno v:
Biological Chemistry. :080808070011441-29
Posttranslational modifications influence the structure, stability and biological activity of proteins. Most of the reactions are enzyme-catalyzed, but some, such as asparagine (Asn) and glutamine (Gln) deamidation and the isoaspartate (isoAsp) forma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca59845b8eee11595b47de0819819ef6
https://doi.org/10.1515/bc.2008.123_bchm.just-accepted
https://doi.org/10.1515/bc.2008.123_bchm.just-accepted