Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Hans-Heinrich Hoffmann"'
Autor:
Tomás Cervantes Rincón, Tania Kapoor, Jennifer R. Keeffe, Luca Simonelli, Hans-Heinrich Hoffmann, Marianna Agudelo, Andrea Jurado, Avery Peace, Yu E. Lee, Anna Gazumyan, Francesca Guidetti, Jasmine Cantergiani, Benedetta Cena, Filippo Bianchini, Elia Tamagnini, Simone G. Moro, Pavel Svoboda, Federico Costa, Mitermayer G. Reis, Albert I. Ko, Brian A. Fallon, Santiago Avila-Rios, Gustavo Reyes-Téran, Charles M. Rice, Michel C. Nussenzweig, Pamela J. Bjorkman, Daniel Ruzek, Luca Varani, Margaret R. MacDonald, Davide F. Robbiani
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114298- (2024)
Summary: Flaviviruses such as dengue virus (DENV), Zika virus (ZIKV), and yellow fever virus (YFV) are spread by mosquitoes and cause human disease and mortality in tropical areas. In contrast, Powassan virus (POWV), which causes severe neurologic il
Externí odkaz:
https://doaj.org/article/f2a8209fd48e4756be5a885d97b8d72f
Autor:
Natalia Cheshenko, Jeffrey B. Bonanno, Hans-Heinrich Hoffmann, Rohit K. Jangra, Kartik Chandran, Charles M. Rice, Steven C. Almo, Betsy C. Herold
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Abstract Herpes simplex virus (HSV) receptor engagement activates phospholipid scramblase triggering Akt translocation to the outer leaflet of the plasma membrane where its subsequent phosphorylation promotes viral entry. We hypothesize that this pre
Externí odkaz:
https://doaj.org/article/866ea4e637e248b58ed8a93146f4518b
Autor:
Natalia Cheshenko, Jeffrey B. Bonanno, Hans-Heinrich Hoffmann, Rohit K. Jangra, Kartik Chandran, Charles M. Rice, Steven C. Almo, Betsy C. Herold
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/4d1acc8e80fd4e28a655751b6003208d
Autor:
Sandra Nakandakari-Higa, Roham Parsa, Bernardo S. Reis, Renan V. H. de Carvalho, Luka Mesin, Hans-Heinrich Hoffmann, Juliana Bortolatto, Hiromi Muramatsu, Paulo. J. C. Lin, Angelina M. Bilate, Charles M. Rice, Norbert Pardi, Daniel Mucida, Gabriel D. Victora, Maria Cecilia C. Canesso
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Efficient mouse models to study SARS-CoV-2 infection are critical for the development and assessment of vaccines and therapeutic approaches to mitigate the current pandemic and prevent reemergence of COVID-19. While the first generation of mouse mode
Externí odkaz:
https://doaj.org/article/03a40c2ab38f4b908a732a3ff73ed920
Autor:
Andrew M. Cheung, Elaine Z. Yip, Alison W. Ashbrook, Niluka Goonawardane, Corrine Quirk, Charles M. Rice, Margaret R. MacDonald, Hans-Heinrich Hoffmann
Publikováno v:
Vaccines, Vol 11, Iss 3, p 612 (2023)
Powassan virus (POWV) is an emerging tick-borne virus and cause of lethal encephalitis in humans. The lack of treatment or prevention strategies for POWV disease underscores the need for an effective POWV vaccine. Here, we took two independent approa
Externí odkaz:
https://doaj.org/article/c9877e3cacd14c7f98a32cc80b007701
Autor:
Frank J. Piscotta, Hans-Heinrich Hoffmann, Young Joo Choi, Gabriel I. Small, Alison W. Ashbrook, Bimal Koirala, Elizabeth A. Campbell, Seth A. Darst, Charles M. Rice, Sean F. Brady
Publikováno v:
mSphere, Vol 6, Iss 6 (2021)
ABSTRACT The COVID-19 pandemic has highlighted the need to identify additional antiviral small molecules to complement existing therapies. Although increasing evidence suggests that metabolites produced by the human microbiome have diverse biological
Externí odkaz:
https://doaj.org/article/b1866295b89c43e5b7d805cf12594bc0
Autor:
Yiska Weisblum, Fabian Schmidt, Fengwen Zhang, Justin DaSilva, Daniel Poston, Julio CC Lorenzi, Frauke Muecksch, Magdalena Rutkowska, Hans-Heinrich Hoffmann, Eleftherios Michailidis, Christian Gaebler, Marianna Agudelo, Alice Cho, Zijun Wang, Anna Gazumyan, Melissa Cipolla, Larry Luchsinger, Christopher D Hillyer, Marina Caskey, Davide F Robbiani, Charles M Rice, Michel C Nussenzweig, Theodora Hatziioannou, Paul D Bieniasz
Publikováno v:
eLife, Vol 9 (2020)
Neutralizing antibodies elicited by prior infection or vaccination are likely to be key for future protection of individuals and populations against SARS-CoV-2. Moreover, passively administered antibodies are among the most promising therapeutic and
Externí odkaz:
https://doaj.org/article/79b3d5db1a464b1183d621d965b32b35
NS5A Promotes Constitutive Degradation of IP3R3 to Counteract Apoptosis Induced by Hepatitis C Virus
Autor:
Shafi Kuchay, Mohsan Saeed, Carlotta Giorgi, Jie Li, Hans-Heinrich Hoffmann, Paolo Pinton, Charles M. Rice, Michele Pagano
Publikováno v:
Cell Reports, Vol 25, Iss 4, Pp 833-840.e3 (2018)
Summary: FBXL2 targets IP3R3 for ubiquitin-mediated degradation to limit Ca2+ flux to mitochondria and, consequently, apoptosis. Efficient replication of hepatitis C virus (HCV) requires geranylgeranylation of FBXL2. Here, we show that the viral prot
Externí odkaz:
https://doaj.org/article/da219c7ebe694db1a53793f1e479a96b
Autor:
Jiwoon Park, Yuanyuan Zhao, Fan Zhang, Shaoyan Zhang, Andrew C. Kwong, Yujie Zhang, Hans-Heinrich Hoffmann, Leila Bushweller, Xin Wu, Alison W. Ashbrook, Branko Stefanovic, Shuyang Chen, Andrea D. Branch, Christopher E. Mason, Jae U. Jung, Charles M. Rice, Xianfang Wu
Publikováno v:
Journal of Hepatology. 78:45-56
A number of genetic polymorphisms have been associated with susceptibility to or protection against non-alcoholic fatty liver disease (NAFLD), but the underlying mechanisms remain unknown. Here, we focused on the rs738409 CG single nucleotide polymor
Publikováno v:
Current Opinion in Virology
Flaviviruses are zoonotic pathogens transmitted by the bite of infected mosquitos and ticks and represent a constant burden to human health. Here we review recent literature aimed at uncovering how flaviviruses interact with the cells that they infec