Zobrazeno 1 - 10
of 286
pro vyhledávání: '"Hans-Georg Koch"'
Autor:
Florian H. Leinberger, Liam Cassidy, Daniel Edelmann, Nicole E. Schmid, Markus Oberpaul, Patrick Blumenkamp, Sebastian Schmidt, Ana Natriashvili, Maximilian H. Ulbrich, Andreas Tholey, Hans-Georg Koch, Bork A. Berghoff
Publikováno v:
mSystems, Vol 9, Iss 11 (2024)
ABSTRACT Bacterial dormancy is a valuable strategy to survive stressful conditions. Toxins from chromosomal toxin-antitoxin systems have the potential to halt cell growth, induce dormancy, and eventually promote a stress-tolerant persister state. Due
Externí odkaz:
https://doaj.org/article/20caf0cecab74ec189e84ea0c76e4f6a
Autor:
Hong Jiang, Martin Milanov, Gabriela Jüngert, Larissa Angebauer, Clara Flender, Eva Smudde, Fabian Gather, Tanja Vogel, Henning J. Jessen, Hans-Georg Koch
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110215- (2024)
Summary: The universally conserved YchF/Ola1 ATPases regulate stress response pathways in prokaryotes and eukaryotes. Deletion of YchF/Ola1 leads to increased resistance against environmental stressors, such as reactive oxygen species, while their up
Externí odkaz:
https://doaj.org/article/ad77c4f54f964b80ae1e6d30f1abff67
Autor:
Denis G. Knyazev, Lukas Winter, Andreas Vogt, Sandra Posch, Yavuz Öztürk, Christine Siligan, Nikolaus Goessweiner-Mohr, Nora Hagleitner-Ertugrul, Hans-Georg Koch, Peter Pohl
Publikováno v:
Biomolecules, Vol 13, Iss 12, p 1774 (2023)
The universally conserved protein YidC aids in the insertion and folding of transmembrane polypeptides. Supposedly, a charged arginine faces its hydrophobic lipid core, facilitating polypeptide sliding along YidC’s surface. How the membrane barrier
Externí odkaz:
https://doaj.org/article/4a5b2448fb7b4c3581e73361d01c6d93
Autor:
Pinku Sarmah, Wenkang Shang, Andrea Origi, Mariya Licheva, Claudine Kraft, Maximilian Ulbrich, Elisabeth Lichtenberg, Annegret Wilde, Hans-Georg Koch
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112140- (2023)
Summary: Signal-sequence-dependent protein targeting is essential for the spatiotemporal organization of eukaryotic and prokaryotic cells and is facilitated by dedicated protein targeting factors such as the signal recognition particle (SRP). However
Externí odkaz:
https://doaj.org/article/1712e4bef72d4d4a97dd5483b74b7e2c
Autor:
Laura Czech, Christopher-Nils Mais, Hanna Kratzat, Pinku Sarmah, Pietro Giammarinaro, Sven-Andreas Freibert, Hanna Folke Esser, Joanna Musial, Otto Berninghausen, Wieland Steinchen, Roland Beckmann, Hans-Georg Koch, Gert Bange
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Bacterial responses to nutrient limitation and other stress conditions are often modulated by the nucleotide-based second messenger (p)ppGpp. Here, the authors show that (p)ppGpp inhibits the SRP membrane-protein insertion and secretion pathway by bi
Externí odkaz:
https://doaj.org/article/61ed31ca782f463ca798cb2a7dd3a7ad
Autor:
Yavuz Öztürk, Andreea Andrei, Crysten E. Blaby-Haas, Noel Daum, Fevzi Daldal, Hans-Georg Koch
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT Metabolic sensing is a crucial prerequisite for cells to adjust their physiology to rapidly changing environments. In bacteria, the response to intra- and extracellular ligands is primarily controlled by transcriptional regulators, which act
Externí odkaz:
https://doaj.org/article/4156c4c141f44e8a9b6c04f3b795d0cf
Publikováno v:
PLoS Biology, Vol 20, Iss 3, p e3001558 (2022)
Membrane proteins require protein machineries to insert their hydrophobic transmembrane domains (TMDs) into the lipid bilayer. A functional analysis of protein insertases in this issue of PLOS Biology reveals that the fundamental mechanism of membran
Externí odkaz:
https://doaj.org/article/2eb0cb6720ca40c8a977ffbfcd5b3718
Autor:
Sebastian Jung, Verian Bader, Ana Natriashvili, Hans-Georg Koch, Konstanze F. Winklhofer, Jörg Tatzelt
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract OmpC and OmpF are among the most abundant outer membrane proteins in E. coli and serve as hydrophilic channels to mediate uptake of small molecules including antibiotics. Influx selectivity is controlled by the so-called constriction zone or
Externí odkaz:
https://doaj.org/article/85496819d379446e91f9fae7cfa50b28
Autor:
Yavuz Öztürk, Crysten E. Blaby-Haas, Noel Daum, Andreea Andrei, Juna Rauch, Fevzi Daldal, Hans-Georg Koch
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Copper (Cu) is an essential cofactor required for redox enzymes in all domains of life. Because of its toxicity, tightly controlled mechanisms ensure Cu delivery for cuproenzyme biogenesis and simultaneously protect cells against toxic Cu. Many Gram-
Externí odkaz:
https://doaj.org/article/570073a8224844fc84bf06804cd96cb4
Autor:
Andreea Andrei, Maria Agostina Di Renzo, Yavuz Öztürk, Alexandra Meisner, Noel Daum, Fabian Frank, Juna Rauch, Fevzi Daldal, Susana L. A. Andrade, Hans-Georg Koch
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Copper (Cu)-transporting P1B-type ATPases are ubiquitous metal transporters and crucial for maintaining Cu homeostasis in all domains of life. In bacteria, the P1B-type ATPase CopA is required for Cu-detoxification and exports excess Cu(I) in an ATP-
Externí odkaz:
https://doaj.org/article/baf69a86f5c34d5e8ae4f14f17907354