Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Hans-Georg Häcker"'
Autor:
Claudia Vicente Martin, Stephan Stocker, Manel Bautista, Vincent Rogue, Caroline Steib-Lauer, Hans-Georg Häcker, Dirk Spickermann, Stefan Hirsch, Sundeep S. Dhareshwar
Publikováno v:
Drug Development and Industrial Pharmacy. 48:211-225
This work summarizes select methodology of twin-screw melt granulation (TSMG) and process analytical technology that were used in the successful scaling-up and commercial transfer of high drug load (80.5% w/w) immediate release fevipiprant tablets.Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad504b8145a93f7741654754e0ec3b6a
https://doi.org/10.1080/03639045.2022.2104307
https://doi.org/10.1080/03639045.2022.2104307
Autor:
Antje de la Haye, Michael Gütschow, Katja Sterz, Michael Wiese, Hans-Georg Häcker, Gregor Schnakenburg
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6102-6105
P-glycoprotein (P-gp) is an important factor in the development of multidrug resistance (MDR) in cancer cells. In literature reports, a thieno[2,3-d]pyrimidine (QB13) was described as P-gp modulator and opposed effects on the cell accumulation of dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c5d3e1bd36f5a39922b0301124f3241
https://doi.org/10.1016/j.bmcl.2009.09.023
https://doi.org/10.1016/j.bmcl.2009.09.023
Autor:
Gregor Schnakenburg, Markus Pietsch, Wilfried Hoffbauer, Hans-Georg Häcker, Michael Gütschow, Jörg Daniels
Publikováno v:
Journal of Molecular Structure. 934:23-27
The normal acid salt isopropylammonium tetrafluorohydrogenphthalate (3) was prepared and its structure was determined by X-ray crystallography. This salt is stabilized by N–H…O, O–H…O, C–H…O, and N–H…F hydrogen bonds. Compound 3 was c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::393a5e65f23b2bf0da22db422c6d2ea7
https://doi.org/10.1016/j.molstruc.2009.06.013
https://doi.org/10.1016/j.molstruc.2009.06.013
Autor:
Susanne Michels, Michael Gütschow, Paul W. Elsinghorst, Jörg Daniels, Hans-Georg Häcker, Gregor Schnakenburg
Publikováno v:
Synthesis. 2009:1195-1203
The reactions of N-benzoyl-N'-(o-cyanoaryl)thioureas with ethyl bromoacetate under alkaline conditions led to the formation of either fused 2-(alkylsulfanyl)-4-aminopyrimidines or 2-(benzoylimino)-3-(o-cyanoaryl)thiazolidin-4-ones. The accurate appli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f4655cf64d89a635a5c9614542f19b3
https://doi.org/10.1055/s-0028-1087995
https://doi.org/10.1055/s-0028-1087995
Autor:
Markus Pietsch, Gregor Schnakenburg, Michael Gütschow, Wilfried Hoffbauer, Hans-Georg Häcker, Martin Nieger
Publikováno v:
Journal of Molecular Structure. 878:131-138
An anomalous acid salt ( 2 ) in the 2:1 ratio of tetrafluorophthalic acid and isopropylamine was prepared from bis(isopropylammonium) tetrafluorophthalate ( 1 ). Both salts were characterized by 13 C NMR spectroscopy in solution and in solid state, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1e60755334411e753c90ad719756ea7
https://doi.org/10.1016/j.molstruc.2007.07.044
https://doi.org/10.1016/j.molstruc.2007.07.044
Publikováno v:
Int. Journal of Clinical Pharmacology and Therapeutics. 48:445-447
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b5a2852fb3ac58da0e186c3183ac2c1
https://doi.org/10.5414/cpp48445
https://doi.org/10.5414/cpp48445
Autor:
Paul W. Elsinghorst, Gregor Schnakenburg, Hans-Georg Häcker, Philipp A. Ottersbach, Michael Gütschow
Publikováno v:
Tetrahedron Letters. 51:2727-2729
The reaction of isatoic anhydride (1) with carbon disulfide at room temperature unexpectedly afforded 1,2-dihydro-2-thioxo-4H-3,1-benzothiazin-4-one (2). The use of 13C-labeled carbon disulfide elucidated that CS2 was entirely incorporated into the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d2e87affc950cfb8b1f34147f6e4882
https://doi.org/10.1016/j.tetlet.2010.03.042
https://doi.org/10.1016/j.tetlet.2010.03.042
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4761-4763
We present a novel lead for inhibitors of multidrug resistance-associated proteins (MRPs). Compound 1 (4-[(5,6,7,8-tetrahydro-4-oxo-4H-[1]benzothieno[2,3-d][1,3]thiazin-2-yl)amino]benzoic acid) was about six times more potent than the known inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc6977ad6314d1b609dfd3a348d9533
https://doi.org/10.1016/j.bmcl.2008.07.127
https://doi.org/10.1016/j.bmcl.2008.07.127
Publikováno v:
Pharmacologytherapeutics. 132(2)
Caspases are proteolytic enzymes mainly involved in the induction and execution phases of apoptosis. This type of programmed cell death is an essential regulatory process required to maintain the integrity and homeostasis of multicellular organisms.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a14aab2811558acedff03d1d4c24c8
https://pubmed.ncbi.nlm.nih.gov/21807025
https://pubmed.ncbi.nlm.nih.gov/21807025
Publikováno v:
ACS combinatorial science. 13(1)
Acylureas (ureides) are valued for their important biological activities. Whereas cyclic acylureas have frequently been the object of solid-phase chemistry, only few reports have focused on the solid-supported preparation of acyclic representatives.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dba94547570de27bf71626905e92e5e
https://pubmed.ncbi.nlm.nih.gov/21247126
https://pubmed.ncbi.nlm.nih.gov/21247126