Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Hans-Günther Knaus"'
Autor:
Marina Peball, Beatrice Heim, Federico Carbone, Oliver Schorr, Mario Werkmann, Philipp Ellmerer, Kathrin Marini, Florian Krismer, Hans-Günther Knaus, Werner Poewe, Atbin Djamshidian, Klaus Seppi
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-10 (2024)
Abstract The synthetic tetrahydrocannabinol-analog nabilone improved non-motor symptoms (NMS) in Parkinson’s disease (PD) patients in a placebo-controlled, double-blind, parallel-group, randomized withdrawal trial with enriched enrollment (NMS-Nab-
Externí odkaz:
https://doaj.org/article/b0a9c2055c614d2596ba8d6fa7898541
Autor:
Marina Peball, Hanno Ulmer, Hans-Günther Knaus, Atbin Djamshidian, Heike Stockner, Klaus Seppi, Beatrice Heim, Kurt Krejcy, Werner Poewe, Philipp Ellmerer, Florian Krismer, Gregor K. Wenning, Dora Valent, Georg Goebel, Kathrin Marini, Mario Werkmann, Raphaela Stolz, Federico Carbone
Publikováno v:
Annals of Neurology
Objective The objective of this study was to assess the efficacy and safety of nabilone, a synthetic tetrahydrocannabinol analogue, as a treatment for non-motor symptoms (NMS) in Parkinson's disease (PD). Methods This was a phase II placebo-controlle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7c7a85c389b0cadc0d2d78af0354b2
https://doi.org/10.1002/ana.25864
https://doi.org/10.1002/ana.25864
Autor:
Marina Peball, Klaus Seppi, Florian Krismer, Hans‐Günther Knaus, Sabine Spielberger, Beatrice Heim, Philipp Ellmerer, Mario Werkmann, Werner Poewe, Atbin Djamshidian
Publikováno v:
Movement disorders clinical practice. 9(6)
The synthetic tetrahydrocannabinol analogue nabilone improved overall non-motor symptom (NMS) burden in Parkinson's disease (PD) patients in comparison to placebo.To characterize the effects of nabilone on different sleep outcomes in PD patients.We p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baad4621cf38d2938c287fc6b9013650
https://pubmed.ncbi.nlm.nih.gov/36190551
https://pubmed.ncbi.nlm.nih.gov/36190551
Autor:
Klaus Seppi, Hanno Ulmer, Marina Peball, Raphaela Stolz, Hans-Günther Knaus, Dora Valent, Atbin Djamshidian, Werner Poewe, Philipp Ellmerer, Mario Werkmann
Publikováno v:
Journal of Neural Transmission
Although open-label observations report a positive effect of cannabinoids on non-motor symptoms (NMS) in Parkinson’s disease (PD) patients, these effects remain to be investigated in a controlled trial for a broader use in NMS in PD patients. There
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f98c0047e302b973e7756b06c367b222
https://pubmed.ncbi.nlm.nih.gov/31129719
https://pubmed.ncbi.nlm.nih.gov/31129719
Publikováno v:
Journal of Comparative Neurology. 524:2093-2116
The sodium-activated potassium channels Slick (Slo2.1, KCNT2) and Slack (Slo2.2, KCNT1) are high-conductance potassium channels of the Slo family. In neurons, Slick and Slack channels are involved in the generation of slow afterhyperpolarization, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::694b13a7656303e547146cc114ac4da6
https://doi.org/10.1002/cne.23934
https://doi.org/10.1002/cne.23934
Autor:
Hans-Günther Knaus, Josef Marksteiner, Klaus Seppi, Michael Willis, Irmgard Leitner, Maria Trieb, Georg Wietzorrek
Publikováno v:
Brain structurefunction. 223(6)
In this study, we investigated the tissue expression levels, alpha subunit composition and distribution of Shaker-related voltage-dependent potassium Kv1 channels in human hippocampus by combining western blotting experiments, toxin autoradiography,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc9930e60c2a8e6a64dffb5ef5cc8ad4
https://pubmed.ncbi.nlm.nih.gov/29564531
https://pubmed.ncbi.nlm.nih.gov/29564531
Autor:
Maria Trieb, Josef Marksteiner, Hans-Günther Knaus, Michael Willis, Georg Wietzorrek, Irmgard Leitner
Publikováno v:
Brain Structure & Function
SK2 (KCa2.2) channels are voltage-independent Ca2+-activated K+ channels that regulate neuronal excitability in brain regions important for memory formation. In this study, we investigated the distribution and expression of SK2 channels in human brai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d623429c01f15b284c93cccb2564bc
https://pubmed.ncbi.nlm.nih.gov/27357310
https://pubmed.ncbi.nlm.nih.gov/27357310
Autor:
Laura Piccoli, E. Merlo-Pich, Corrado Corti, Chiara Cazzin, Zita Rovó, N. Garbati, Francesca Michielin, Anita Lüthi, Mauro Corsi, Simone Astori, M. Massagrande, Christopher J. Ring, Alastair Morrison, Hans-Günther Knaus
Publikováno v:
Genes brain and behavior
The voltage-gated potassium channel Kv1.2 belongs to the shaker-related family and has recently been implicated in the control of sleep profile on the basis of clinical and experimental evidence in rodents. To further investigate whether increasing K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e8ee45d50c8ebdd2ac5958442713a97
Autor:
Hans-Günther Knaus, Luis F. Pacheco Otalora, Ileana Garcia, Frank Skinner, Carlos Fernando Mello, Boris Ermolinsky, Emilio R. Garrido-Sanabria, Massoud F. Arshadmansab, Mauro Schneider Oliveira
Publikováno v:
Brain Research. 1348:187-199
Small conductance calcium (Ca(2+)) activated SK channels are critical regulators of neuronal excitability in hippocampus. Accordingly, these channels are thought to play a key role in controlling neuronal activity in acute models of epilepsy. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2375d08673d56e3621faa48a878e16fb
https://doi.org/10.1016/j.brainres.2010.05.095
https://doi.org/10.1016/j.brainres.2010.05.095
Autor:
Johan F. Storm, Ole Petter Ottersen, Francesco Ferraguti, Hans-Günther Knaus, Joseph Sexton, Yu Kasugai, Georg Wietzorrek, Yugo Fukazawa, Petter Laake, Peter Ruth, Walter A. Kaufmann, Ryuichi Shigemoto
Publikováno v:
The Journal of Comparative Neurology. 515:215-230
Calcium-activated potassium channels have been shown to be critically involved in neuronal function, but an elucidation of their detailed roles awaits identification of the microdomains where they are located. This study was undertaken to unravel the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15517a117489e85a9615bb792cc2a711
https://doi.org/10.1002/cne.22066
https://doi.org/10.1002/cne.22066