Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Hans-Dieter Jakubke"'
Autor:
Norbert Sewald, Hans-Dieter Jakubke
Thoroughly updated, incorporating around 25% new material, Sewald/Jakubke remains the only modern and scientifically up-to-date advanced textbook on peptide biochemistry, distilling the knowledge of hundreds of publications into a highly readable syn
Publikováno v:
Enzyme Catalysis in Organic Synthesis, Third Edition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02deab513dd0c9ac36de95a24a671f2c
https://doi.org/10.1002/9783527639861.ch17
https://doi.org/10.1002/9783527639861.ch17
Reconstructing the Binding Site of Factor Xa in Trypsin Reveals Ligand-induced Structural Plasticity
Autor:
Sabine Reyda, Kathrin Rall, Gerhard Klebe, Hans Dieter Jakubke, Christian Sohn, Dirk Ullmann, Milton T. Stubbs
Publikováno v:
Journal of Molecular Biology. 325:963-977
In order to investigate issues of selectivity and specificity in protein-ligand interactions, we have undertaken the reconstruction of the binding pocket of human factor Xa in the structurally related rat trypsin by site-directed mutagenesis. Three s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb8eac5fcf8474978f267c8c0ef7b6b9
https://doi.org/10.1016/s0022-2836(02)01337-2
https://doi.org/10.1016/s0022-2836(02)01337-2
Autor:
Václav Čeřovský, Hans-Dieter Jakubke
Publikováno v:
Biotechnology and Bioengineering. 49:553-558
Nucleophile specificity of subtilisin (subtilopeptidase A) was studied via acyl transfer reactions in acetonitrile containing piperidine and 10 vol% of water. Ac-Tyr-OEt was used as acyl donor and a series of amino acid derivatives, di- and tripeptid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12fdcbb2f8442f4f35fc9f3477dcbbba
https://doi.org/10.1002/(sici)1097-0290(19960305)49:5<553::aid-bit8>3.0.co
https://doi.org/10.1002/(sici)1097-0290(19960305)49:5<553::aid-bit8>3.0.co
Autor:
Sibylla Grahn, Dirk Ullmann, Sebastian H.J. Bauer, Torsten Kurth, Christian Elsner, Hans-Dieter Jakubke
Publikováno v:
Journal of Molecular Catalysis B: Enzymatic. 8:193-200
Chemical modifications are a simple method to identify and modify functional determinants of enzymes. In the case of serine proteases, it is possible to induce characteristics which are advantageous for peptide synthesis. In this work, we investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2b6aabced0108e6b3dfcb8c13c7d657
https://doi.org/10.1016/s1381-1177(99)00057-0
https://doi.org/10.1016/s1381-1177(99)00057-0
Publikováno v:
Tetrahedron: Asymmetry. 10:307-313
A peptide library consisting of di- and tripeptide esters and tripeptide amides, respectively, containing α-Tfm amino acids in different positions was synthesized and tested for enzymatic fragment condensations catalyzed by the proteases α-chymotry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d23fa3298217ebcbebfafc0177914701
https://doi.org/10.1016/s0957-4166(98)00508-4
https://doi.org/10.1016/s0957-4166(98)00508-4
Autor:
Hans-Dieter Jakubke, Frank Bordusa
Publikováno v:
Bioorganic & Medicinal Chemistry. 6:1775-1780
The S1'-S3' subsite specificity of prolyl endopeptidase from Flavobacterium meningoseptum was studied by acyl transfer to libraries of amino acid amides and peptides. Whereas the S1' and S3' subsites influence the specificity for the amino component
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4cb534e255f9864e4268086c9527266
https://doi.org/10.1016/s0968-0896(98)00145-x
https://doi.org/10.1016/s0968-0896(98)00145-x
Autor:
Torsten Kurth, Hans-Dieter Jakubke, Michael Thormann, Sibylla Grahn, Lizbeth Hedstrom, Hans-Jörg Hofmann, Dirk Ullmann
Publikováno v:
Biochemistry. 37:11434-11440
The serine protease trypsin was converted into a site-specific protease which hydrolyzes peptides between dibasic residues. Trypsin exhibits a high S1 specificity for Arg and Lys residues. However, the S1' specificity of trypsin is very broad, with o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c54448359cab6b3b499db2335b5dd3e
https://doi.org/10.1021/bi980842z
https://doi.org/10.1021/bi980842z
Publikováno v:
Nucleosides and Nucleotides. 17:1267-1274
Synthesis of guanylyl(3′→5′)cytidine catalysed by RNase T1 variants (Tyr42Trp, Tyr24Trp and GluSSAla) was studied in frozen aqueous systems at-10°C and in solution at 0°C. Freezing the reaction mixture resulted in significantly enhanced dinuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2be53712d5b67ef888e8d1f3996fa4e4
https://doi.org/10.1080/07328319808004238
https://doi.org/10.1080/07328319808004238
Autor:
Hans-Dieter Jakubke, Marion Haensler
Publikováno v:
Enzyme and Microbial Technology. 22:617-620
The capability of endoproteinase Pro-C from Flavobacterium meningosepticum to form peptide bonds in frozen aqueous systems was investigated. In coupling of Bz-Gly-Pro-OMe with various amino acid amides, free amino acids, and dipeptides, freezing-indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1c4f57db3bc75a3d9f3114f3954b943
https://doi.org/10.1016/s0141-0229(98)00260-9
https://doi.org/10.1016/s0141-0229(98)00260-9