Beyond the polymerase-γ theory: Production of ROS as a mode of NRTI-induced mitochondrial toxicity.

Autor: Reuben L Smith, Josephine M E Tan, Martijs J Jonker, Aldo Jongejan, Thomas Buissink, Steve Veldhuijzen, Antoine H C van Kampen, Stanley Brul, Hans van der Spek

Publikováno v: PLoS ONE, Vol 12, Iss 11, p e0187424 (2017)

Use of some HIV-1 nucleoside reverse transcriptase inhibitors (NRTI) is associated with severe adverse events. However, the exact mechanisms behind their toxicity has not been fully understood. Mitochondrial dysfunction after chronic exposure to spec

Externí odkaz: https://doaj.org/article/36804a76b9a047ff8edcbcd90b040ad2

Beyond the polymerase-γ theory

Autor: Steve Veldhuijzen, Stanley Brul, Martijs J. Jonker, Reuben L. Smith, Aldo Jongejan, Thomas Buissink, Antoine H. C. van Kampen, Hans van der Spek, Josephine M. E. Tan

Publikováno v: PLoS ONE, 12(11):e0187424. Public Library of Science
PLoS ONE
PLoS ONE, Vol 12, Iss 11, p e0187424 (2017)
PLoS ONE, 12(11). Public Library of Science

Use of some HIV-1 nucleoside reverse transcriptase inhibitors (NRTI) is associated with severe adverse events. However, the exact mechanisms behind their toxicity has not been fully understood. Mitochondrial dysfunction after chronic exposure to spec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd2a41dcea89535dfd16668df55eb2b7
https://dare.uva.nl/personal/pure/en/publications/beyond-the-polymerase-theory(87f9fe49-aca8-428b-9896-93f546ea493b).html

Caenorhabditis elegans as a Model System for Studying Drug Induced Mitochondrial Toxicity

Autor: Stanley Brul, Erik Mm M. Manders, Hans van der Spek, Winnok H. De Vos, Richard F. de Boer, Ruben L. Smith

Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0126220 (2015)
PLoS ONE
PLoS ONE, 10(5):e0126220. Public Library of Science

Today HIV-1 infection is recognized as a chronic disease with obligatory lifelong treatment to keep viral titers below detectable levels. The continuous intake of antiretroviral drugs however, leads to severe and even life-threatening side effects, s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c228ca6b105b9f7f5474434916ca3cf
http://europepmc.org/articles/PMC4430419?pdf=render

Increased synthesis and decreased stability of mitochondrial translation products in yeast as a result of loss of mitochondrial (NAD(+))-dependent isocitrate dehydrogenase

Autor: Mark T. McCammon, Liesbeth de Jong, Leslie A. Grivell, Hans van der Spek, Sandra D. J. Elzinga

Publikováno v: FEBS Letters, 483, 62-66. Wiley-Blackwell

We have previously demonstrated that the yeast Krebs cycle enzyme NAD+-dependent isocitrate dehydrogenase (Idh) binds specifically and with high affinity to the 5′-untranslated leader sequences of mitochondrial mRNAs in vitro and have proposed a ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2317dd1da8832244b69a493110ab06b5
https://hdl.handle.net/11245/1.175824

RNA editing in mitochondria of cultured trypanosomatids: Translatable mRNAs for NADH-dehydrogenase subunits are missing

Autor: Janny van den Burg, Rob Benne, G. J. Arts, Hans van der Spek, Paul Sloof

Publikováno v: Journal of Bioenergetics and Biomembranes. 26:193-203

RNA editing in mitochondria of kinetoplastid protozoa involves the posttranscriptional insertion and deletion of uridylate residues in protein encoding regions of pre-mRNAs. Editing is required to remove gene-encoded translational defects or to conve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90360549981221ef17a44dbcb697cbb2
https://doi.org/10.1007/bf00763068