Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Hans de Bont"'
Autor:
Esmee Koedoot, Michiel Fokkelman, Vasiliki-Maria Rogkoti, Marcel Smid, Iris van de Sandt, Hans de Bont, Chantal Pont, Janna E. Klip, Steven Wink, Mieke A. Timmermans, Erik A. C. Wiemer, Peter Stoilov, John A. Foekens, Sylvia E. Le Dévédec, John W. M. Martens, Bob van de Water
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Triple-negative breast cancers (TNBC) have enhanced migratory behaviour. Here, the authors perform a phenotypic imaging-based RNAi screen to identify several genes associated with regulation of migratory phenotypes and show that one of the regulators
Externí odkaz:
https://doaj.org/article/720606fcf5f54cc0ae38a7db6f491bec
Autor:
Veerander P S Ghotra, Shuning He, Hans de Bont, Wietske van der Ent, Herman P Spaink, Bob van de Water, B Ewa Snaar-Jagalska, Erik H J Danen
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31281 (2012)
A quantitative bio-imaging platform is developed for analysis of human cancer dissemination in a short-term vertebrate xenotransplantation assay. Six days after implantation of cancer cells in zebrafish embryos, automated imaging in 96 well plates co
Externí odkaz:
https://doaj.org/article/98586dadc5d548bd80b730a293942246
Autor:
Erik H.J. Danen, B. Ewa Snaar-Jagalska, Gabri van der Pluijm, Bob van de Water, Jiangling Xiong, Zuzanna Baranski, Esther I. Verhoef, A. Marije M. Hoogland, Geert J.L.H. van Leenders, Guido Jenster, Richard Janssen, Annemarie Lekkerkerker, Hans de Bont, Steffen Nijhoff, Geertje van der Horst, Shuning He, Veerander P.S. Ghotra
Supplemental Figures S1-S5 Figure S1. Whole organism automated bioimaging assay differentiates between androgen independent / metastatic and androgen-dependent / non-metastatic prostate cancer cells. Figure S2. SYK depletion attenuates PC3 disseminat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d0f09c98c42bfca7990d71c8d583d38
https://doi.org/10.1158/0008-5472.22405436
https://doi.org/10.1158/0008-5472.22405436
Publikováno v:
Biochemical Pharmacology, 169, 113640
Enhanced expression and activity of protein kinases are critical in tumor cell proliferation and cancer progression. These various cancer-related kinases form intricate interdependent signaling networks. Evaluation of the effect of various kinase inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a44f41bd58ac5b930328fa313dd3161f
https://doi.org/10.1016/j.bcp.2019.113640
https://doi.org/10.1016/j.bcp.2019.113640
Autor:
Steven Wink, Maarten L. J. Coonen, Leo S. Price, Bob van de Water, Jan Snoeys, Karen van den Nieuwendijk, Giulia Callegaro, Anita C A Dankers, Danyel Jennen, Hans de Bont, Sreenivasa Ramaiahgari, John H. N. Meerman, Steven Hiemstra
Publikováno v:
Archives of Toxicology, 93(10), 2895-2911. Springer
Archives of Toxicology
Archives of Toxicology, 93(10), 2895-2911
Archives of Toxicology
Archives of Toxicology, 93(10), 2895-2911
Adaptive stress response pathways play a key role in the switch between adaptation and adversity, and are important in drug-induced liver injury. Previously, we have established an HepG2 fluorescent protein reporter platform to monitor adaptive stres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2445be77905a17240006bd9b20e545a
https://cris.maastrichtuniversity.nl/en/publications/1f4662e0-f46b-4dff-8312-6340f0cd0c0d
https://cris.maastrichtuniversity.nl/en/publications/1f4662e0-f46b-4dff-8312-6340f0cd0c0d
Autor:
Sylvia E. Le Dévédec, Michiel Fokkelman, Anna. M. Timmermans, Chantal Pont, John W.M. Martens, John A. Foekens, Bob van de Water, Peter Stoilov, Marcel Smid, Hans de Bont, Erik A.C. Wiemer, Iris van de Sandt, Janna E. Klip, Vasiliki-Maria Rogkoti, Esmee Koedoot, Steven Wink
Publikováno v:
Nature Communications, 10(1), 2983
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications, 10:2983. Nature Publishing Group
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications, 10:2983. Nature Publishing Group
Nature Communications
Ttriple-negative breast cancer (TNBC) is an aggressive and highly metastatic breast cancer subtype. Enhanced TNBC cell motility is a prerequisite of TNBC cell dissemination. Here, we apply an imaging-based RNAi phenotypic cell migration screen using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2feece2f0728cd7c3f55eb14a625e103
http://hdl.handle.net/1887/79045
http://hdl.handle.net/1887/79045
Autor:
Erik A.C. Wiemer, Peter Stoilov, Iris van de Sandt, John W.M. Martens, Sylvia E. Le Dévédec, Esmee Koedoot, Vasiliki-Maria Rogkoti, John A. Foekens, Janna E. Klip, Marcel Smid, Michiel Fokkelman, Hans de Bont, Chantal Pont, Bob van de Water
Metastasis is the major cause of death in cancer patients and migration of cancer cells from the primary tumor to distant sites is the prerequisite of metastasis formation. Here we applied an imaging-based RNAi phenotypic cell migration screen using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6495327fc31379d44c0ad8e4d5f5ae94
https://doi.org/10.1101/479568
https://doi.org/10.1101/479568
Autor:
Bram Herpers, Lisa Fredriksson, Mackenzie Hadi, Bob van de Water, Giulia Benedetti, Geny M. M. Groothuis, Hans de Bont, Erik H.J. Danen, John H. N. Meerman, Marjo de Graauw, Mirjam Luijten, Steven Wink
Publikováno v:
Toxicological Sciences, 140(1), 144-159
Drug-induced liver injury (DILI) is an important clinical problem. Here, we used a genomics approach to in detail investigate the hypothesis that critical drug-induced toxicity pathways act in synergy with the pro-inflammatory cytokine tumor necrosis
Autor:
Harry Vrieling, Hans de Bont, Giel Hendriks, Bram Herpers, Steven Wink, Bob van de Water, Zi Di, Lisa Fredriksson
Publikováno v:
Archives of Toxicology, 90(5), 1163-1179
Archives of Toxicology
Archives of Toxicology
Drug-induced liver injury (DILI) is an important problem both in the clinic and in the development of new safer medicines. Two pivotal adaptation and survival responses to adverse drug reactions are oxidative stress and cytokine signaling based on th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ec8fb638c8545f759e89db50714647
https://hdl.handle.net/1887/46780
https://hdl.handle.net/1887/46780
Autor:
Reshma A. Lalai, Bob van de Water, Hans de Bont, Martine H. van Miltenburg, Eveline van Waaij, Erik H.J. Danen, Hilary E. Beggs
Publikováno v:
The FASEB Journal. 23:3482-3493
The adult, virgin mammary gland is a highly organized branched ductal network comprising two major cell types: myoepithelial and luminal epithelial cells. To study the role and mechanism of focal adhesion kinase (FAK)-mediated signaling in mammary gl