Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Hans Zischler"'
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
The male mammalian germline is characterized by substantial chromatin remodeling associated with the transition from histones to protamines during spermatogenesis, followed by the reversal to nucleohistones in the male pronucleus preceding the zygoti
Externí odkaz:
https://doaj.org/article/3d3eb5c07d2643e4945ea160986052a6
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Cellular senescence is characterized by replication arrest in response to stress stimuli. Senescent cells accumulate in aging tissues and can trigger organ-specific and possibly systemic dysfunction. Although senescent cell populations are heterogene
Externí odkaz:
https://doaj.org/article/32e9853e4a6d43cea317f12c7a7cb057
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Most epigenetic information is reprogrammed during gametogenesis and early development. However, some epigenetic information persists and can be inherited, a phenomenon that is common in plants. On the other hand, there are increasing examples of epi
Externí odkaz:
https://doaj.org/article/4f3ab6b6813149148734deca088292e5
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Cells of the developing human brain are affected by the progressive acquisition of genetic and epigenetic alterations that have been reported to contribute to somatic mosaicism in the adult brain and are increasingly considered a possible cause of ne
Externí odkaz:
https://doaj.org/article/3b764955a19842c787b65ae0b6637413
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
R-loops are three-stranded nucleic acid structures consisting of an RNA:DNA hybrid and a displaced DNA strand. While R-loops pose a potential threat to genome integrity, they constitute 5% of the human genome. The role of R-loops in transcriptional r
Externí odkaz:
https://doaj.org/article/d79b3fa4a4004ca59755d784ff85dd1f
Autor:
Katharina M. Mauer, Hanno Schmidt, Marco Dittrich, Andreas C. Fröbius, Sören Lukas Hellmann, Hans Zischler, Thomas Hankeln, Holger Herlyn
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-24 (2021)
Abstract Background Seisonidea (also Seisonacea or Seisonidae) is a group of small animals living on marine crustaceans (Nebalia spec.) with only four species described so far. Its monophyletic origin with mostly free-living wheel animals (Monogonont
Externí odkaz:
https://doaj.org/article/e068b5ecbea34159bdf23ab1f644ecc3
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Studies on the function of PRDM9 in model systems and its evolution during vertebrate divergence shed light on the basic molecular mechanisms of hybrid sterility and its evolutionary consequences. However, information regarding PRDM9-homolog, PRDM7,
Externí odkaz:
https://doaj.org/article/1af46731446a40b4bd223071971e5ac7
The genome, transcriptome, and proteome of the fish parasite Pomphorhynchus laevis (Acanthocephala).
Autor:
Katharina Mauer, Sören Lukas Hellmann, Marco Groth, Andreas C Fröbius, Hans Zischler, Thomas Hankeln, Holger Herlyn
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0232973 (2020)
Thorny-headed worms (Acanthocephala) are endoparasites exploiting Mandibulata (Arthropoda) and Gnathostomata (Vertebrata). Despite their world-wide occurrence and economic relevance as a pest, genome and transcriptome assemblies have not been publish
Externí odkaz:
https://doaj.org/article/1042fb15782546ecb7d6f86970be2aac
Publikováno v:
Genomics Data, Vol 5, Iss C, Pp 309-313 (2015)
The role of the Piwi/piRNA pathway during mammalian oogenesis has remained enigmatic thus far, especially since experiments with Piwi knockout mice did not reveal any phenotypic defects in female individuals. This is in striking contrast with results
Externí odkaz:
https://doaj.org/article/f7fc06cedffa4cba914653222a3fbf11
Autor:
Elke F. Roovers, David Rosenkranz, Mahdi Mahdipour, Chung-Ting Han, Nannan He, Susana M. Chuva de Sousa Lopes, Lucette A.J. van der Westerlaken, Hans Zischler, Falk Butter, Bernard A.J. Roelen, René F. Ketting
Publikováno v:
Cell Reports, Vol 10, Iss 12, Pp 2069-2082 (2015)
Germ cells of most animals critically depend on piRNAs and Piwi proteins. Surprisingly, piRNAs in mouse oocytes are relatively rare and dispensable. We present compelling evidence for strong Piwi and piRNA expression in oocytes of other mammals. Huma
Externí odkaz:
https://doaj.org/article/e6ff335ba2ba4aeca2b0ee808d99219a