Genome-wide association analysis of diverticular disease points towards neuromuscular, connective tissue and epithelial pathomechanisms

Autor: Mauro D'Amato, Robert Grützmann, Ilka Vogel, Andreas Walther-Berends, Thomas Becker, Frank Lammert, Michael Schroeder, Petr Sergeev, Laura Sophie Noack, Jürgen Tepel, Jonas Rosendahl, A Herrmann, Thilo Wedel, Clemens Schafmayer, Witigo von Schönfels, Patrick Michl, Wolfgang Kruis, Michael Krawczak, Bodo Schniewind, Holger Hinrichsen, Gerd Focke, Hans Wolfgang Schimming, Ursula Huber-Schönauer, Christina Lange, Sebastian Wolff, Thorsten Jacobi, RV Thangapandi, James W. Harrison, Robin N Beaumont, Philipp Hofer, Martina Böttner, Juozas Kupcinskas, Henry Völzke, Melanie Langheinrich, Christian Datz, Hans Boedeker, Jens Uwe Erk, Mario Brosch, Jessica Tyrrell, Andreas Volk, Andre Franke, Torsten Kucharzik, Leonora Pietsch, Andrew R. Wood, Greta Burmeister, Stephan Buch, Alexander Hendricks, Wolfgang Lieb, Limas Kupčinskas, Juergen Weitz, Michael N. Weedon, François Cossais, Jochen Hampe, Andrea Gsur, Myrko Zobel, Peter T. Schmidt, Stefan Palm, Matthias C. Reichert, Sebastian Hinz, Sebastian Zeissig, Anna Andreasson, Stefanie Brezina, Gernot Leeb

Publikováno v: Gut

ObjectiveDiverticular disease is a common complex disorder characterised by mucosal outpouchings of the colonic wall that manifests through complications such as diverticulitis, perforation and bleeding. We report the to date largest genome-wide asso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b1890494be3957759b0aa268b11b943
https://doi.org/10.1136/gutjnl-2018-317619