Zobrazeno 1 - 10
of 331
pro vyhledávání: '"Hans W. Nijman"'
Autor:
Anneke L. Eerkens, Koen Brummel, Annegé Vledder, Sterre T. Paijens, Marta Requesens, Dominik Loiero, Nienke van Rooij, Annechien Plat, Floris-Jan Haan, Patty Klok, Refika Yigit, Thijs Roelofsen, Natascha M. de Lange, Rie Klomp, David Church, Arja ter Elst, René Wardenaar, Diana Spierings, Floris Foijer, Viktor Hendrik Koelzer, Tjalling Bosse, Joost Bart, Mathilde Jalving, Anna K. L. Reyners, Marco de Bruyn, Hans W. Nijman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Neoadjuvant immune checkpoint blockade (ICB) has shown unprecedented activity in mismatch repair deficient (MMRd) colorectal cancers, but its effectiveness in MMRd endometrial cancer (EC) remains unknown. In this investigator-driven, phase I
Externí odkaz:
https://doaj.org/article/1b7aedf643dd44ed914769ada0de8d61
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Genomic instability is a driver and accelerator of tumorigenesis and influences disease outcomes across cancer types. Although genomic instability has been associated with immune evasion and worsened disease prognosis, emerging evidence shows that ge
Externí odkaz:
https://doaj.org/article/c0b5e02b942c476fa734476fa62d514e
Autor:
Ester P. Olthof, Brenda J. Bergink-Voorthuis, Hans H. B. Wenzel, Jordy Mongula, Jacobus van der Velden, Anje M. Spijkerboer, Judit A. Adam, Ruud L. M. Bekkers, Jogchum J. Beltman, Brigitte F. M. Slangen, Hans W. Nijman, Ramon G. V. Smolders, Nienke E. van Trommel, Petra L. M. Zusterzeel, Ronald P. Zweemer, Lukas J. A. Stalpers, Constantijne H. Mom, Maaike A. van der Aa
Publikováno v:
Insights into Imaging, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Objectives Imaging is increasingly used to assess lymph node involvement in clinically early-stage cervical cancer. This retrospective study aimed to evaluate the diagnostic accuracy of MRI, CT, and [18F]FDG-PET-CT. Methods Women with Intern
Externí odkaz:
https://doaj.org/article/d0fa9ae14884488382643f5adb6cfe0e
Publikováno v:
EJNMMI Research, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Background Immune checkpoint inhibitors (ICIs) have made significant progress in oncotherapy improving survival of patients. However, the benefits are limited to only a small subgroup of patients who could achieve durable responses. Early pr
Externí odkaz:
https://doaj.org/article/2766395661714f37a72f12e6bba44659
Autor:
Xiaoyu Fan, Marta A. Ważyńska, Arjan Kol, Noemi Perujo Holland, Bruna Fernandes, Sander M. J. van Duijnhoven, Annechien Plat, Hans van Eenennaam, Philip H. Elsinga, Hans W. Nijman, Marco de Bruyn
Publikováno v:
EJNMMI Research, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Background CD103 is an integrin specifically expressed on the surface of cancer-reactive T cells. The number of CD103+ T cells significantly increases during successful immunotherapy and might therefore be an attractive biomarker for noninva
Externí odkaz:
https://doaj.org/article/42504525a87d43f6acda5c05efb66f5a
Autor:
Nanda Horeweg, Hagma H. Workel, Dominik Loiero, David N. Church, Lisa Vermij, Alicia Léon-Castillo, Ricki T. Krog, Stephanie M. de Boer, Remi A. Nout, Melanie E. Powell, Linda R. Mileshkin, Helen MacKay, Alexandra Leary, Naveena Singh, Ina M. Jürgenliemk-Schulz, Vincent T. H. B. M. Smit, Carien L. Creutzberg, Viktor H. Koelzer, Hans W. Nijman, Tjalling Bosse, Marco de Bruyn, TransPORTEC consortium
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Tertiary lymphoid structures (TLS) are associated with a reduced risk of cancer recurrence and improved response to immune checkpoint blockade in several tumor types. Here the authors identify L1CAM as a marker for mature TLS and show that the presen
Externí odkaz:
https://doaj.org/article/6cc5d5b840f843b2b959b31b5c279a0f
Autor:
Danique Giesen, Hans van Eenennaam, Hans W. Nijman, Marco de Bruyn, Arjan Kol, Xiaoyu Fan, Marta A. Wazynska, Sander M.J. van Duijnhoven, Annechien Plat, Philip H. Elsinga
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 12 (2022)
Purpose CD103, an integrin specifically expressed on the surface of cancer-reactive T cells, is significantly increased during successful immunotherapy across human malignancies. In this study, we describe the generation and zirconium-89 (89Zr) radio
Externí odkaz:
https://doaj.org/article/f55b3137b2b94aa192c9ac5565a27b1d
Autor:
Koen De Decker, Karina H. Jaroch, Joost Bart, Loes F. S. Kooreman, Roy F. P. M. Kruitwagen, Hans W. Nijman, Arnold-Jan Kruse
Publikováno v:
Journal of Ovarian Research, Vol 14, Iss 1, Pp 1-6 (2021)
Abstract Background A frozen section diagnosis of a borderline ovarian tumor with suspicious features of invasive carcinoma (“at least borderline” or synonymous descriptions) presents us with the dilemma of whether or not to perform a full ovaria
Externí odkaz:
https://doaj.org/article/496d1d8948d34f6ca7a3bff2aa70ff1e
Autor:
Martijn Vlaming, Vrouyr Bilemjian, Jimena Álvarez Freile, Vinicio Melo, Annechien Plat, Gerwin Huls, Hans W. Nijman, Marco de Bruyn, Edwin Bremer
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Reactivation of tumor infiltrating T lymphocytes (TILs) with immune checkpoint inhibitors or co-stimulators has proven to be an effective anti-cancer strategy for a broad range of malignancies. However, epithelial ovarian cancer (EOC) remains largely
Externí odkaz:
https://doaj.org/article/465eb515f65948b7a151ebb599965783
Autor:
Koen De Decker, Henk G. ter Brugge, Joost Bart, Roy F.P.M. Kruitwagen, Hans W. Nijman, Arnold-Jan Kruse
Publikováno v:
Gynecologic Oncology Reports, Vol 27, Iss , Pp 25-30 (2019)
Objectives: Discordance between frozen section diagnosis and the definite histopathological diagnosis and the fact that the frozen section result is not always unambiguous, may contribute to differences in clinical practice regarding perioperative tr
Externí odkaz:
https://doaj.org/article/c4c432d469fe4500b4aee0f650180074