Výsledky vyhledávání - "Hans W. Klafki"

Akademický článek

N-truncated Aβ4–x peptides in sporadic Alzheimer’s disease cases and transgenic Alzheimer mouse models

Autor: Oliver Wirths, Susanne Walter, Inga Kraus, Hans W. Klafki, Martina Stazi, Timo J. Oberstein, Jorge Ghiso, Jens Wiltfang, Thomas A. Bayer, Sascha Weggen

Publikováno v: Alzheimer’s Research & Therapy, Vol 9, Iss 1, Pp 1-12 (2017)

Abstract Background The deposition of neurotoxic amyloid-β (Aβ) peptides in plaques in the brain parenchyma and in cerebral blood vessels is considered to be a key event in Alzheimer’s disease (AD) pathogenesis. Although the presence and impact o

Externí odkaz: https://doaj.org/article/6e0a0a2d6bb24114a8fa3fc6fcb54b8a

Zobrazit plný text záznamu

Akademický článek

Diagnostic performance of automated plasma amyloid-β assays combined with pre-analytical immunoprecipitation

Autor: Hans-W. Klafki, Jonathan Vogelgsang, Ekaterina Manuilova, Chris Bauer, Alexander Jethwa, Hermann Esselmann, Anke Jahn-Brodmann, Dirk Osterloh, Ingolf Lachmann, Benedict Breitling, Carolin Rauter, Niels Hansen, Caroline Bouter, Stefan Palme, Johannes Schuchhardt, Jens Wiltfang

Publikováno v: Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-12 (2022)

Abstract Background Measurements of the amyloid-β (Aβ) 42/40 ratio in blood plasma may support the early diagnosis of Alzheimer’s disease and aid in the selection of suitable participants in clinical trials. Here, we compared the diagnostic perfo

Externí odkaz: https://doaj.org/article/8da3b40d1bf84fd48476aee2b9f1f3e0

Zobrazit plný text záznamu

Plný text ve formátu HTML

Validation of a Chemiluminescence Immunoassay for Measuring Amyloid-β in Human Blood Plasma

Autor: Jonathan, Vogelgsang, Jens, Wiltfang, Hans W, Klafki

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1750

The technical performance of immunological assays and their suitability for the intended use should be carefully validated before implementation in research, clinical studies or routine. We describe here the evaluation of a sandwich electrochemilumin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::81ff1667674e39e32f8d601d836e4e80
https://pubmed.ncbi.nlm.nih.gov/29512068

Zobrazit plný text záznamu

Additional file 3: of A two-step immunoassay for the simultaneous assessment of Aβ38, Aβ40 and Aβ42 in human blood plasma supports the Aβ42/Aβ40 ratio as a promising biomarker candidate of Alzheimer’s disease

Autor: Hedieh Shahpasand-Kroner, Hans-W. Klafki, Bauer, Chris, Schuchhardt, Johannes, Hüttenrauch, Melanie, Stazi, Martina, Bouter, Caroline, Wirths, Oliver, Vogelgsang, Jonathan, Wiltfang, Jens

Aβ42 standard curves of the two MSD assay plates applied to analysis of the clinical sample. (PDF 277 kb)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d49fd01e7eeb159472b6a825b9f6e65

Zobrazit plný text záznamu

Additional file 5: of A two-step immunoassay for the simultaneous assessment of Aβ38, Aβ40 and Aβ42 in human blood plasma supports the Aβ42/Aβ40 ratio as a promising biomarker candidate of Alzheimer’s disease

Autor: Hedieh Shahpasand-Kroner, Hans-W. Klafki, Bauer, Chris, Schuchhardt, Johannes, Hüttenrauch, Melanie, Stazi, Martina, Bouter, Caroline, Wirths, Oliver, Vogelgsang, Jonathan, Wiltfang, Jens

Baseline statistics of measured Aβ38, Aβ40 and Aβ42 levels in diluted IP eluates and the concentration ratios Aβ42/Aβ40, Aβ42/Aβ38 and Aβ38/Aβ40. (PDF 183 kb)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f6cd36d3a397af39fc21c31e3a4360

Zobrazit plný text záznamu

Additional file 4: of A two-step immunoassay for the simultaneous assessment of Aβ38, Aβ40 and Aβ42 in human blood plasma supports the Aβ42/Aβ40 ratio as a promising biomarker candidate of Alzheimer’s disease

Autor: Hedieh Shahpasand-Kroner, Hans-W. Klafki, Bauer, Chris, Schuchhardt, Johannes, Hüttenrauch, Melanie, Stazi, Martina, Bouter, Caroline, Wirths, Oliver, Vogelgsang, Jonathan, Wiltfang, Jens

Intra-assay variation of the multiplex Aβ immunoassay. (PDF 51 kb)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05babe71a03271c314a25f484eaafa1e

Zobrazit plný text záznamu

Additional file 8: of A two-step immunoassay for the simultaneous assessment of Aβ38, Aβ40 and Aβ42 in human blood plasma supports the Aβ42/Aβ40 ratio as a promising biomarker candidate of Alzheimer’s disease

Autor: Hedieh Shahpasand-Kroner, Hans-W. Klafki, Bauer, Chris, Schuchhardt, Johannes, Hüttenrauch, Melanie, Stazi, Martina, Bouter, Caroline, Wirths, Oliver, Vogelgsang, Jonathan, Wiltfang, Jens

Concentrations of Aβ38 and Aβ40 in IP eluates were strongly correlated with each other. (PDF 96 kb)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f60d902250530d6a185cba97ac79421

Zobrazit plný text záznamu

Reproducibility of Alzheimer's Disease Cerebrospinal Fluid-Biomarker Measurements under Clinical Routine Conditions

Autor: Jonathan Vogelgsang, Dirk Wedekind, Caroline Bouter, Hans-W. Klafki, Jens Wiltfang

Publikováno v: Journal of Alzheimer's disease 62(1), 203-212 (2018). doi:10.3233/JAD-170793
Journal of Alzheimer's Disease

Analysis of cerebrospinal fluid (CSF) is one of the key tools for the state-of-the-art differential diagnosis of dementias. Dementia due to Alzheimer’s disease (AD) is characterized by elevated CSF levels of total Tau (tTau) and phospho-181-Tau (pT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8391ce0e833e4fd43081b29cd0ee0652

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání