A Fluorescent Live Imaging Screening Assay Based on Translocation Criteria Identifies Novel Cytoplasmic Proteins Implicated in G Protein-coupled Receptor Signaling Pathways

Autor: Rainer Pepperkok, Sandra Lecat, Jeremy C. Simpson, Jean-Luc Galzi, Hans W. D. Matthes

Publikováno v: Molecular and Cellular Proteomics
Molecular and Cellular Proteomics, American Society for Biochemistry and Molecular Biology, 2015, 14 (5), pp.1385-1399. ⟨10.1074/mcp.M114.046698⟩

International audience; Several cytoplasmic proteins that are involved in G protein-coupled receptor signalling cascades are known to translocate to the plasma membrane upon receptor activation, such as beta-arrestin2. Based on this example and in or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fdb94d22560c67d8476322894f1ed97

Quantitative autoradiography of adenosine receptors and NBTI-sensitive adenosine transporters in the brains and spinal cords of mice deficient in the μ-opioid receptor gene

Autor: Ian Kitchen, Alexis Bailey, Hans W. D. Matthes, Susanna M.O. Hourani, Brigitte L. Kieffer, Susan Slowe

Publikováno v: Brain Research. 943:68-79

There is a large body of evidence indicating important interactions between the adenosine and opioid systems in regulating pain at both the spinal and supraspinal level. Mice lacking the mu-opioid receptor (MOR) gene have been successfully developed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dee48c2012d90221a0fa638e2e9bda4f
https://doi.org/10.1016/s0006-8993(02)02536-2

Lack of dependence and rewarding effects of deltorphin II in mu-opioid receptor-deficient mice

Autor: Daniel M. Hutcheson, Hans W. D. Matthes, Emmanuel Valjent, Pilar Sanchez-Blazquez, Marta Rodriguez-Diaz, Javier Garzon, Brigitte L. Kieffer, Rafael Maldonado

Publikováno v: European Journal of Neuroscience. 13:153-161

We have previously shown that the antinociceptive effects produced by the delta opioid-selective agonist deltorphin II are preserved in mu-opioid receptor (MOR)-deficient mice. We have now investigated rewarding effects and physical dependence produc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1fc50b23e8593a96e637d282db6fe2b
https://doi.org/10.1046/j.1460-9568.2001.01363.x

Specific activation of the μ opioid receptor (MOR) by endomorphin 1 and endomorphin 2

Autor: Brigitte L. Kieffer, Hans W. D. Matthes, Marie Claude Bourin, Anna Borsodi, Jacques Hanoune, Krisztina Monory, Csaba Tömböly, Géza Tóth, Mariana Spetea

Publikováno v: European Journal of Neuroscience. 12:577-584

The recently discovered endomorphin 1 (Tyr-Pro-Trp-Phe-NH2) and endomorphin 2 (Tyr-Pro-Phe-Phe-NH2) were investigated with respect to their direct receptor-binding properties, and to their ability to activate G proteins and to inhibit adenylyl cyclas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::068138a8c8f71b3674dfe581763ba026
https://doi.org/10.1046/j.1460-9568.2000.00936.x

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

Autor: Rafael Maldonado, Frédéric Simonin, Pascal Dollé, Marianne Le Meur, Ian Kitchen, Hans W. D. Matthes, Susan Slowe, Eleni T. Tzavara, Katia Befort, Bernard P. Roques, Olga Valverde, Brigitte L. Kieffer, Andrée Dierich, Jacques Hanoune

Publikováno v: Nature. 383:819-823

Despite tremendous efforts in the search for safe, efficacious and non-addictive opioids for pain treatment, morphine remains the most valuable painkiller in contemporary medicine. Opioids exert their pharmacological actions through three opioid-rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40474f46bad6c6e03674f5878dac357e
https://doi.org/10.1038/383819a0