Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Hans W Mages"'
Autor:
Annabell eBachem, Evelyn eHartung, Steffen eGüttler, Ahmed eMora, Xuefei eZhou, Anika eHegemann, Maud ePlantinga, Elisa eMazzini, Patrizia eStoitzner, Stephanie eGurka, Volker eHenn, Hans W Mages, Richard A. Kroczek
Publikováno v:
Frontiers in Immunology, Vol 3 (2012)
Cross-presentation of antigen by dendritic cells (DCs) to CD8+ T cells is a fundamentally important mechanism in the defense against pathogens and tumors. Due to the lack of an appropriate lineage marker, cross-presenting DCs in the mouse are provisi
Externí odkaz:
https://doaj.org/article/f8fee15c4fc241bb8b1863269f18d105
Autor:
Mette M. Rosenkilde, Christian Berg, Hans W. Mages, Richard A. Kroczek, Julia Madela, Viktorija Daugvilaite, Agnieszka Bauer, Sebastian Voigt, Stephanie Gurka
Publikováno v:
Bauer, A, Madela, J, Berg, C, Daugvilaite, V, Gurka, S, Mages, H W, Kroczek, R A, Rosenkilde, M M & Voigt, S 2020, ' Rat cytomegalovirus-encoded γ-chemokine vXCL1 is a highly adapted, species-specific agonist for rat XCR1-positive dendritic cells ', Journal of Cell Science, vol. 133, no. 5, jcs236190. . https://doi.org/10.1242/jcs.236190
Dendritic cells (DCs) expressing the chemokine receptor XCR1 are specialized in antigen cross-presentation to control infections with intracellular pathogens. XCR1-positive (XCR1+) DCs are attracted by XCL1, a γ-chemokine secreted by activated CD8+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88016d654ec9ab41747b3539686225ac
https://doi.org/10.1242/jcs.236190
https://doi.org/10.1242/jcs.236190
Autor:
Arthur L. Kroczek, Evelyn Hartung, Stephanie Gurka, Martina Becker, Nele Reeg, Hans W. Mages, Sebastian Voigt, Christian Freund, Richard A. Kroczek
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology, Vol 9 (2018)
XCL1 is the ligand for XCR1, a chemokine receptor uniquely expressed on crosspresenting dendritic cells (DC) in mouse and man. We are interested in establishing therapeutic vaccines based on XCL1-mediated targeting of peptides or proteins into these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea40b3e0663257e661b1a1479525b3a
https://doi.org/10.3389/fimmu.2018.02806
https://doi.org/10.3389/fimmu.2018.02806
Autor:
Wolfgang Schuh, Joachim R. Grün, Jan P. Weber, Randi K. Feist, Annette Lahmann, Mir-Farzin Mashreghi, Dana Vu Van, Lea-Jean Gentz, Maysun S. Al Baz, Claudia Haftmann, Andreas Radbruch, René Riedel, Franziska Fuhrmann, Hans W. Mages, Andreas Hutloff, Richard A. Kroczek
Publikováno v:
The Journal of Experimental Medicine
ICOS signaling is required for inhibition of the transcription factor Klf2, which controls expression of genes expressed by follicular T helper (Tfh) cells. When ICOS signaling is blocked, Tfh cells lose expression of characteristic Tfh genes and rev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2549305a233c26e1ca98504fb283c866
https://doi.org/10.1084/jem.20141432
https://doi.org/10.1084/jem.20141432
Autor:
Konstantinos Anastassiadis, Annabell Bachem, Hans W. Mages, Richard A. Kroczek, Stephanie Gurka, Christoph Weise, Claudia Giesecke, Andreas Hutloff, Nele Reeg, Harald Weber, Volker Henn, Evelyn Hartung, Martina Becker, Anika Jäkel
Publikováno v:
The Journal of Immunology. 194:1069-1079
Current subunit vaccines are incapable of inducing Ag-specific CD8+ T cell cytotoxicity needed for the defense of certain infections and for therapy of neoplastic diseases. In experimental vaccines, cytotoxic responses can be elicited by targeting of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5c6f8bd58943b59ba4f8b62ab846d27
https://doi.org/10.4049/jimmunol.1401903
https://doi.org/10.4049/jimmunol.1401903
Autor:
Dana Vu Van, Timo Lischke, Hans W. Mages, Kong-Peng Lam, Andreas Hutloff, Richard A. Kroczek, Anika Hegemann, Hans-Joachim Mollenkopf, Stephanie Gurka, Yvonne Burmeister, Olivia Kershaw
Publikováno v:
The Journal of Immunology. 189:234-244
We have established a comprehensive in vivo mouse model for the CD4+ T cell response to an “innocuous” versus “dangerous” exogenous Ag and developed an in vivo test for tolerance. In this model, specific gene-expression signatures, distinctiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c705bd7c41b09872b5f541c0302f2c06
https://doi.org/10.4049/jimmunol.1102034
https://doi.org/10.4049/jimmunol.1102034
Publikováno v:
Current Opinion in Immunology. 16:321-327
The analysis of recent data reveals that T-cell co-stimulation is a hierarchical process with elements of mutual interdependence between individual co-stimulators. The expression and function of co-stimulatory molecules is biased on various T-cell su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecdf673d6f2c5eb84d55c52f21b8600b
https://doi.org/10.1016/j.coi.2004.03.002
https://doi.org/10.1016/j.coi.2004.03.002
Autor:
Hans W. Mages, Richard A. Kroczek, Tilmann Kallinich, Eckard Hamelmann, Andreas Radbruch, Andreas Hutloff, Kerstin Bonhagen, Max Löhning
Publikováno v:
The Journal of Experimental Medicine
The studies performed to date analyzed the overall participation of the inducible costimulator (ICOS) in model diseases, but did not yield information on the nature and function of ICOS-expressing T cells in vivo. We examined ICOS+ T cells in the sec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fbdd0ab63d72bf64c6a4926de8c5215
http://europepmc.org/articles/PMC2193816
http://europepmc.org/articles/PMC2193816
Autor:
Matthias Peiser, Helmut Jonuleit, Hans W. Mages, Kerstin Büchner, Esther J. Witsch, Richard A. Kroczek, Andreas Hutloff, Brigitte G. Dorner
Publikováno v:
European Journal of Immunology. 32:2680-2686
With newly generated ICOS-ligand (ICOS-L)-specific monoclonal antibodies we determined that human Langerhans cells in situ express similar levels of ICOS-L, CD80, and CD86, compared to immature dendritic cells (DC) derived from monocytes in vitro. Ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4242e09a16c097dc35ea8ed4f3f2c229
https://doi.org/10.1002/1521-4141(200209)32:9<2680::aid-immu2680>3.0.co
https://doi.org/10.1002/1521-4141(200209)32:9<2680::aid-immu2680>3.0.co
Autor:
Annabell Bachem, Stephanie Gurka, Martina Becker, Anika Jäkel, Steffen Güttler, Evelyn Hartung, Hans W. Mages, Ahmed Mora, Volker Henn, Richard A. Kroczek, Andreas Hutloff
Publikováno v:
Frontiers in Immunology, Vol 5 (2014)
Frontiers in Immunology
Frontiers in Immunology
In the past, lack of lineage markers confounded the classification of dendritic cells (DC) in the intestine and impeded a full understanding of their location and function. We have recently shown that the chemokine receptor XCR1 is a lineage marker f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d9c984e924048619486afe3b0fd8dfd
http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00326/full
http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00326/full