Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Hans Voshol"'
Autor:
Yannick Mesrouze, Gustavo Aguilar, Marco Meyerhofer, Fedir Bokhovchuk, Catherine Zimmermann, Patrizia Fontana, Alexandra Vissières, Hans Voshol, Dirk Erdmann, Markus Affolter, Patrick Chène
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract The TEAD transcription factors are the most downstream elements of the Hippo pathway. Their transcriptional activity is modulated by different regulator proteins and by the palmitoylation/myristoylation of a specific cysteine residue. In thi
Externí odkaz:
https://doaj.org/article/f02b86fa3df24797a39ed636e8605ba1
Autor:
Bin Huang, Tanja Lucas, Claudia Kueppers, Xiaomin Dong, Maike Krause, Alexander Bepperling, Johannes Buchner, Hans Voshol, Andreas Weiss, Bertran Gerrits, Stefan Kochanek
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121055 (2015)
Huntingtin (Htt) is a 350 kD intracellular protein, ubiquitously expressed and mainly localized in the cytoplasm. Huntington's disease (HD) is caused by a CAG triplet amplification in exon 1 of the corresponding gene resulting in a polyglutamine (pol
Externí odkaz:
https://doaj.org/article/3b23bdd193b741028d28c792570ecdf2
Autor:
Chrysiis Michaloglou, Waltraut Lehmann, Typhaine Martin, Clara Delaunay, Andreas Hueber, Louise Barys, Honglin Niu, Eric Billy, Markus Wartmann, Moriko Ito, Christopher J Wilson, Mary Ellen Digan, Andreas Bauer, Hans Voshol, Gerhard Christofori, William R Sellers, Francesco Hofmann, Tobias Schmelzle
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61916 (2013)
The Hippo (Hpo) pathway is a novel signaling pathway that controls organ size in Drosophila and mammals and is deregulated in a variety of human cancers. It consists of a set of kinases that, through a number of phosphorylation events, inactivate YAP
Externí odkaz:
https://doaj.org/article/6648f287df874bcc8e7cfe07718ceb1a
Autor:
Jan van Oostrum, Sjouke Hoving, Dieter Müller, Patrick Schindler, Michel Steinmetz, Harry Towbin, Hans Voshol, Urs Wirth
Publikováno v:
CHIMIA, Vol 55, Iss 4 (2001)
The term 'proteome' describes the expressed protein complement of a genome. The largely invariant genome of an individual or organism determines its potential for gene- and protein expression but does not specify which proteins are expressed in the v
Externí odkaz:
https://doaj.org/article/cfff92bc232541aab068dae26d28cf1b
Autor:
Edwige Lorthiois, Marc Gerspacher, Kim S. Beyer, Andrea Vaupel, Catherine Leblanc, Rowan Stringer, Andreas Weiss, Rainer Wilcken, Daniel A. Guthy, Andreas Lingel, Claudio Bomio-Confaglia, Rainer Machauer, Pascal Rigollier, Johannes Ottl, Dorothee Arz, Pascal Bernet, Gaëlle Desjonqueres, Solene Dussauge, Malika Kazic-Legueux, Marie-Anne Lozac’h, Christophe Mura, Mickaël Sorge, Milen Todorov, Nicolas Warin, Florence Zink, Hans Voshol, Frederic J. Zecri, Richard C. Sedrani, Nils Ostermann, Saskia M. Brachmann, Simona Cotesta
Publikováno v:
Journal of Medicinal Chemistry. 65:16173-16203
Autor:
Saskia M. Brachmann, Simona Cotesta, Anna F. Farago, Frederic Zecri, Kun Xu, Rainer Wilcken, Toni Widmer, Peter Wessels, Hans Voshol, Andrea Vaupel, Rowan Stringer, Toshio Shimizu, Richard Sedrani, Christian Schnell, Danielle Roman, Pascal Rigollier, Johannes Ottl, Nils Ostermann, Helen Oakman, Jason Murphy, Sauveur-Michel Maira, Catherine Leblanc, Jeffrey D. Kearns, Eloísa Jiménez Núñez, Ashley Jaeger, Victoria Head, Daniel Alexander Guthy, Marc Gerspacher, Carmine Fedele, Lekshmi Dharmarajan, Ruben de Kanter, Xiaoming Cui, Xueying Chen, Heather Burks, Claudio Bomio-Confaglia, Kim S. Beyer, Louise Barys, Edwige Lorthiois, Andreas Weiss
Supplementary Data from Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d58af020ff3289026b12e3df1b9a0f4
https://doi.org/10.1158/2159-8290.22541471.v1
https://doi.org/10.1158/2159-8290.22541471.v1
Autor:
Saskia M. Brachmann, Simona Cotesta, Anna F. Farago, Frederic Zecri, Kun Xu, Rainer Wilcken, Toni Widmer, Peter Wessels, Hans Voshol, Andrea Vaupel, Rowan Stringer, Toshio Shimizu, Richard Sedrani, Christian Schnell, Danielle Roman, Pascal Rigollier, Johannes Ottl, Nils Ostermann, Helen Oakman, Jason Murphy, Sauveur-Michel Maira, Catherine Leblanc, Jeffrey D. Kearns, Eloísa Jiménez Núñez, Ashley Jaeger, Victoria Head, Daniel Alexander Guthy, Marc Gerspacher, Carmine Fedele, Lekshmi Dharmarajan, Ruben de Kanter, Xiaoming Cui, Xueying Chen, Heather Burks, Claudio Bomio-Confaglia, Kim S. Beyer, Louise Barys, Edwige Lorthiois, Andreas Weiss
Covalent inhibitors of KRASG12C have shown antitumor activity against advanced/metastatic KRASG12C-mutated cancers, though resistance emerges and additional strategies are needed to improve outcomes. JDQ443 is a structurally unique covalent inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::090908cffff39039ae33828ed26022f4
https://doi.org/10.1158/2159-8290.c.6549647
https://doi.org/10.1158/2159-8290.c.6549647
Autor:
Thomas Radimerski, Francesco Hofmann, William R. Sellers, Ross L. Levine, Hans Voshol, Christoph Gaul, Paul W. Manley, Carole Pissot-Soldermann, Fabienne Baffert, Gisele Tavares, Lorenza Wyder, Aviva Goel, Priya Koppikar, Neha Bhagwat, Hugues Ryckelynck, Alain De Pover, Catherine H. Régnier, Fanny Marque, Clemens Scheufler, Eric Vangrevelinghe, Joëlle Rubert, Débora Bonenfant, Zhiyan Qian, Rita Andraos
PDF file - 841K, Supplementary Figures S1-S6; legends for Supplementary Tables S1-S3; Supplementary Methods describing RNA interference, generation of Ba/F3 cell lines, site-directed mutagenesis, transient transfection, inhibition of cellular ATP pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d1c96f82771189e532e391627afa78
https://doi.org/10.1158/2159-8290.22528301.v1
https://doi.org/10.1158/2159-8290.22528301.v1
Autor:
Thomas Radimerski, Francesco Hofmann, William R. Sellers, Ross L. Levine, Hans Voshol, Christoph Gaul, Paul W. Manley, Carole Pissot-Soldermann, Fabienne Baffert, Gisele Tavares, Lorenza Wyder, Aviva Goel, Priya Koppikar, Neha Bhagwat, Hugues Ryckelynck, Alain De Pover, Catherine H. Régnier, Fanny Marque, Clemens Scheufler, Eric Vangrevelinghe, Joëlle Rubert, Débora Bonenfant, Zhiyan Qian, Rita Andraos
PDF file - 11K, Activity of NVP-BBT594 in biochemical and cell-based assays. The IC50 (mean of two experiments) of NVP-BBT594 on the JAK2 kinase was determined in a biochemical kinase assay with the active enzyme. Half-maximal growth inhibition (GI50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31418f731a67ae71f974979b4eddf70
https://doi.org/10.1158/2159-8290.22528298
https://doi.org/10.1158/2159-8290.22528298
Autor:
Saskia M. Brachmann, Michael N. Hall, Francesco Hofmann, William R. Sellers, Sauveur-Michel Maira, Keith Calkins, Mitko Ristov, Daniel Guthy, Mark Stump, David Ruddy, Eric Billy, Malika Kazic-Legueux, Grégory Marszalek, Hélène Erasimus, Janina Juengert, Hans Voshol, Thomas Ferrat, Christian Schnell, Sandra Mollé, Audrey Kauffmann, Barbara Herkert
Despite major dependence of PTENLOF/BRAFMUT melanoma cell lines on PI3Kβ, PI3Kαi synergizes with PI3Kβi to inhibit downstream signaling upon long-term treatment. A) +B) Effects of treatment with the indicated inhibitors as single-agents or in comb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93575cb74b408c503761ce44d54ca36a
https://doi.org/10.1158/0008-5472.22408859
https://doi.org/10.1158/0008-5472.22408859