Zobrazeno 1 - 10
of 537
pro vyhledávání: '"Hans Uwe Simon"'
Autor:
Jean Bousquet, Clive Grattan, Thomas Bieber, Paolo Matricardi, Hans Uwe Simon, Ulrich Wahn, Antonella Muraro, Peter W. Hellings, Ioana Agache
Publikováno v:
Clinical and Translational Allergy, Vol 7, Iss 1, Pp 1-6 (2017)
Abstract The European Academy of Allergy and Clinical Immunology (EAACI) owns three journals: Allergy, Pediatric Allergy and Immunology and Clinical and Translational Allergy. One of the major goals of EAACI is to support health promotion in which pr
Externí odkaz:
https://doaj.org/article/0a3fe70c3f704abd85a9b13ffa1da2a9
Autor:
Christina Bürgler, Danielle Dutoit, Susanne Radonjic‐Hoesli, Kathrin Thormann, Mathias Lehmann, Shida Yousefi, Hans‐Uwe Simon, Dagmar Simon
Publikováno v:
JEADV Clinical Practice, Vol 3, Iss 2, Pp 478-486 (2024)
Abstract Background Atopic dermatitis (AD) is characterized by skin barrier dysfunction and immune dysregulation. Autophagy, which is important for the epidermal differentiation, is impaired in AD. The treatment with dupilumab, an interleukin (IL)‐
Externí odkaz:
https://doaj.org/article/6a435cace1b1481c9e2f281e6735c8c8
Autor:
Lea Gigon, Philipp Müller, Beat Haenni, Ioan Iacovache, Maruša Barbo, Gordana Gosheva, Shida Yousefi, Alice Soragni, Christoph von Ballmoos, Benoît Zuber, Hans-Uwe Simon
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114084- (2024)
Summary: Eosinophils play a crucial role in host defense while also contributing to immunopathology through the release of inflammatory mediators. Characterized by distinctive cytoplasmic granules, eosinophils securely store and rapidly release vario
Externí odkaz:
https://doaj.org/article/d182e05a08354491ada376f038ee4c1c
Autor:
Gulnaz Sharapova, Sirina Sabirova, Marina Gomzikova, Anna Brichkina, Nick A Barlev, Natalia V Kalacheva, Albert Rizvanov, Nikita Markov, Hans-Uwe Simon
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7038 (2024)
The metabolism of glioma cells exhibits significant heterogeneity and is partially responsible for treatment outcomes. Given this variability, we hypothesized that the effectiveness of treatments targeting various metabolic pathways depends on the bi
Externí odkaz:
https://doaj.org/article/f9df743188854f1bbbc7f12170980c13
Autor:
Aref Hosseini, Nina Germic, Nikita Markov, Darko Stojkov, Kevin Oberson, Shida Yousefi, Hans-Uwe Simon
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
IntroductionObesity is a metabolic condition that elevates the risk of all-cause mortality. Brown and beige adipose tissues, known for their thermogenic properties, offer potential therapeutic targets for combating obesity. Recent reports highlight t
Externí odkaz:
https://doaj.org/article/76bbf05ed60842cdb495ddaf1a7098e2
Autor:
Yihe Chen, Nikita Markov, Lea Gigon, Aref Hosseini, Shida Yousefi, Darko Stojkov, Hans-Uwe Simon
Publikováno v:
Cells, Vol 13, Iss 4, p 322 (2024)
Macrophages play a crucial role in the innate immune response, serving as key effector cells in the defense against pathogens. Although the role of the large-conductance voltage and calcium-activated potassium channel, also known as the KCa1.1 or BK
Externí odkaz:
https://doaj.org/article/8ba83f82ee23434fbf39fae61945088b
Autor:
Shuang Peng, Darko Stojkov, Jian Gao, Kevin Oberson, Philipp Latzin, Carmen Casaulta, Shida Yousefi, Hans-Uwe Simon
Publikováno v:
PLoS Biology, Vol 20, Iss 9, p e3001794 (2022)
In contrast to molecular changes associated with increased inflammatory responses, little is known about intracellular counter-regulatory mechanisms that control signaling cascades associated with functional responses of neutrophils. Active RHO GTPas
Externí odkaz:
https://doaj.org/article/c1d2fec0092a4a2da3e099dcff06a06b
Autor:
Mariela Artola-Borán, Angela Fallegger, Martina Priola, Rima Jeske, Tim Waterboer, Anders B. Dohlman, Xiling Shen, Sebastian Wild, Jiazhuo He, Mitchell P. Levesque, Shida Yousefi, Hans-Uwe Simon, Phil F. Cheng, Anne Müller
Publikováno v:
Cell Reports, Vol 38, Iss 6, Pp 110359- (2022)
Summary: The two human pathogens Helicobacter pylori and Mycobacterium tuberculosis (Mtb) co-exist in many geographical areas of the world. Here, using a co-infection model of H. pylori and the Mtb relative M. bovis bacillus Calmette-Guérin (BCG), w
Externí odkaz:
https://doaj.org/article/2705b2607d404df5a267749271d1a3ed
Autor:
Darko Stojkov, Lea Gigon, Shuang Peng, Robert Lukowski, Peter Ruth, Alexander Karaulov, Albert Rizvanov, Nickolai A. Barlev, Shida Yousefi, Hans-Uwe Simon
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Neutrophils are the most numerous cells in the leukocyte population and essential for innate immunity. To limit their effector functions, neutrophils are able to modulate glycolysis and other cellular metabolic pathways. These metabolic pathways are
Externí odkaz:
https://doaj.org/article/c2c431c0300d43ba99b9968b523e4129
Autor:
Kim Klapan, Dagmar Simon, Alexander Karaulov, Marina Gomzikova, Albert Rizvanov, Shida Yousefi, Hans-Uwe Simon
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Autophagy is a highly conserved lysosomal degradation system that involves the creation of autophagosomes, which eventually fuse with lysosomes and breakdown misfolded proteins and damaged organelles with their enzymes. Autophagy is widely known for
Externí odkaz:
https://doaj.org/article/c02be37c36e4406fb64be11551d1d7f1