Angiopoietin-like protein 4 is an exercise-induced hepatokine in humans, regulated by glucagon and cAMP

Autor: Bodil Ingerslev, Jakob S. Hansen, Christoph Hoffmann, Jens O. Clemmesen, Niels H. Secher, Mika Scheler, Martin Hrabĕ de Angelis, Hans U. Häring, Bente K. Pedersen, Cora Weigert, Peter Plomgaard

Publikováno v: Molecular Metabolism, Vol 6, Iss 10, Pp 1286-1295 (2017)

Objective: Angiopoietin-like protein-4 (ANGPTL4) is a circulating protein that is highly expressed in liver and implicated in regulation of plasma triglyceride levels. Systemic ANGPTL4 increases during prolonged fasting and is suggested to be secrete

Externí odkaz: https://doaj.org/article/09fa3316dd9b4a0182e32ce423ccbb02

Identification and regulation of the xenometabolite derivatives cis- and trans-3,4-methylene-heptanoylcarnitine in plasma and skeletal muscle of exercising humans

Autor: Rainer Lehmann, Benedikt Karus, Miriam Hoene, Cora Weigert, Peter Plomgaard, Hans U. Häring, Xinjie Zhao, Guowang Xu, Sean H. Adams, Andreas M. Niess, Hany F. Sobhi, Jakob S. Hansen

Publikováno v: Sobhi, H F, Zhao, X, Plomgaard, P, Hoene, M, Hansen, J S, Karus, B, Niess, A M, Häring, H U, Lehmann, R, Adams, S H, Xu, G & Weigert, C 2020, ' Identification and regulation of the xenometabolite derivatives cis-and trans-3,4-methylene-heptanoylcarnitine in plasma and skeletal muscle of exercising humans ', American Journal of Physiology: Endocrinology and Metabolism, vol. 318, no. 5, pp. E701-E709 . https://doi.org/10.1152/ajpendo.00510.2019
Am. J. Physiol. Endocrinol. Metab. 318, E701-E709 (2020)

Little is known about xenometabolites in human metabolism, particularly under exercising conditions. Previously, an exercise-modifiable, likely xenometabolite derivative, cis-3,4-methylene-heptanoylcarnitine, was reported in human plasma. Here, we id

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2440796c6dd183039b57a450f5295d0
https://curis.ku.dk/portal/da/publications/identification-and-regulation-of-the-xenometabolite-derivatives-cis-and-trans34methyleneheptanoylcarnitine-in-plasma-and-skeletal-muscle-of-exercising-humans(a68fe202-8ff6-4de7-8ba4-4df1be38d317).html

Identification and regulation of the xenometabolite derivatives

Autor: Hany F, Sobhi, Xinjie, Zhao, Peter, Plomgaard, Miriam, Hoene, Jakob S, Hansen, Benedikt, Karus, Andreas M, Niess, Hans U, Häring, Rainer, Lehmann, Sean H, Adams, Guowang, Xu, Cora, Weigert

Publikováno v: American journal of physiology. Endocrinology and metabolism. 318(5)

Little is known about xenometabolites in human metabolism, particularly under exercising conditions. Previously, an exercise-modifiable, likely xenometabolite derivative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c260c5b01b6925329ad404074e577786
https://pubmed.ncbi.nlm.nih.gov/32101032

Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes

Autor: Claudia Lamina, Dawn M. Waterworth, Ramachandran S. Vasan, Alan R. Sinaiko, Jorma Viikari, Alena Stančáková, Nita G. Forouhi, Leo-Pekka Lyytikäinen, Chloe Y Y Cheung, Torben Hansen, Bernhard Paulweber, Ying Wu, Christie M. Ballantyne, Jaakko Tuomilehto, Karen S.L. Lam, Jussi Paananen, James B. Meigs, Jing Hua Zhao, Francis S. Collins, Hans U. Häring, Marie-France Hivert, Joshua W. Knowles, Zari Dastani, Andrew T. Hattersley, Ele Ferrannini, Ching-Ti Liu, Sarah Buxbaum, Mika Kähönen, Peter Henneman, Aurelian Bidulescu, Michael Boehnke, Ruth J. F. Loos, Fatiha el Bouazzaoui, Ulf Smith, Tim D. Spector, Josée Dupuis, Weijia Xie, Thomas Quertermous, Robert K. Semple, Lyudmyla Kedenko, John J. Nolan, Andrew D. Morris, Anne U. Jackson, Cornelia M. van Duijn, Ko Willems van Dijk, Markku Laakso, Robert A. Scott, Na Zhu, Oluf Pedersen, Terho Lehtimäki, Claudia Langenberg, Ke Hao, Christopher J. Gillson, Olli T. Raitakari, Mark I. McCarthy, Florian Kronenberg, Jaeyoung Hong, James S. Pankow, Debbie A Lawlor, Nicholas J. Wareham, Karen L. Mohlke, Timothy M. Frayling, Tanya M. Teslovich, Sandra H. Dunn, Alessandro Doria, Cecilia M. Lindgren, Richard N. Bergman, Johanna Kuusisto, Hanieh Yaghootkar, Liling Warren, Stefan Gustafsson, Erik Ingelsson, Colin N. A. Palmer, Mark Walker, Themistocles L. Assimes, J. Brent Richards

Publikováno v: Diabetes, 62(10), 3589-3598
Yaghootkar, H, Lamina, C, Scott, R A, Dastani, Z, Hivert, M F, Warren, L L, Stancakova, A, Buxbaum, S G, Lyytikaeinen, L P, Henneman, P, Wu, Y, Cheung, C Y Y, Pankow, J S, Jackson, A U, Gustafsson, S, Zhao, J H, Ballantyne, C M, Xie, W J, Bergman, R N, Boehnke, M, el Bouazzaoui, F, Collins, F S, Dunn, S H, Dupuis, J, Forouhi, N G, Gillson, C, Hattersley, A T, Hong, J Y, Kaehoenen, M, Kuusisto, J, Kedenko, L, Kronenberg, F, Doria, A, Assimes, T L, Ferrannini, E, Hansen, T, Hao, K, Haering, H, Knowles, J W, Lindgren, C M, Nolan, J J, Paananen, J, Pedersen, O, Quertermous, T, Smith, U, Lehtimaeki, T, Liu, C T, Loos, R J F, McCarthy, M I, Morris, A D, Vasan, R S, Spector, T D, Teslovich, T M, Tuomilehto, J, van Dijk, K W, Viikari, J S, Zhu, N, Langenberg, C, Ingelsson, E, Semple, R K, Sinaiko, A R, Palmer, C N A, Walker, M, Lam, K S L, Paulweber, B, Mohlke, K L, van Duijn, C, Raitakari, O T, Bidulescu, A, Wareham, N J, Laakso, M, Waterworth, D M, Lawlor, D A, Meigs, J B, Richards, J B, Frayling, T M, Consortium, G & Consortium, R 2013, ' Mendelian Randomization Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes ', Diabetes, vol. 62, pp. 3589-3598 . https://doi.org/10.2337/db13-0128
Diabetes
Yaghootkar, H, Lamina, C, Scott, R A, Dastani, Z, Hivert, M F, Warren, L L, Stancáková, A, Buxbaum, S G, Lyytikäinen, L P, Henneman, P, Wu, Y, Cheung, C Y Y, Pankow, J S, Jackson, A U, Gustafsson, S, Zhao, J H, Ballantyne, C M, Xie, W, Bergman, R N, Boehnke, M, El Bouazzaoui, F, Collins, F S, Dunn, S H, Dupuis, J, Forouhi, N G, Gillson, C, Hattersley, A T, Hong, J, Kähönen, M, Kuusisto, J, Kedenko, L, Kronenberg, F, Doria, A, Assimes, T L, Ferrannini, E, Hansen, T, Hao, K, Häring, H, Knowles, J W, Lindgren, C M, Nolan, J J, Paananen, J, Pedersen, O, Quertermous, T, Smith, U, Lehtimäki, T, Liu, C T, Loos, R J F, McCarthy, M I, Morris, A D, Vasan, R S, Spector, T D, Teslovich, T M, Tuomilehto, J, Van Dijk, K W, Viikari, J S, Zhu, N, Langenberg, C, Ingelsson, E, Semple, R K, Sinaiko, A R, Palmer, C N A, Walker, M, Lam, K S L, Paulweber, B, Mohlke, K L, Van Duijn, C, Raitakari, O T, Bidulescu, A, Wareham, N J, Laakso, M, Waterworth, D M, Lawlor, D A, Meig, J B, Richards, J B & Frayling, T M 2013, ' Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes ', Diabetes, vol. 62, no. 10, pp. 3589-3598 . https://doi.org/10.2337/db13-0128
Diabetes, 62(10), 3589-3598. American Diabetes Association Inc.

Adiponectin is strongly inversely associated with insulin resistance and type 2 diabetes, but its causal role remains controversial. We used a Mendelian randomization approach to test the hypothesis that adiponectin causally influences insulin resist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f2386755cd164d07f113ab70cbd80fe
https://ora.ox.ac.uk/objects/uuid:fd376590-520a-44d4-a377-1d5ba7bc4b0c

Effects of 4-week very-high-fructose/glucose diets on insulin sensitivity, visceral fat and intrahepatic lipids: an exploratory trial

Autor: Susanne Unmuth, Fritz Schick, Andreas Fritsche, Norbert Stefan, Juergen Machann, Hans U. Häring, Guenther Silbernagel

Publikováno v: British Journal of Nutrition. 106:79-86

An increasing amount of fructose in the diet is suggested to play a causal role in the pathogenesis of the metabolic syndrome, type 2 diabetes and fatty liver. Our aim was to investigate and compare the effects of very high fructose and very high glu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7749cc3f93da530e1ccc703788cb05d1
https://doi.org/10.1017/s000711451000574x